{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:45:37Z","timestamp":1789598737912,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1996,9]]},"DOI":"10.1378\/chest.110.3.595","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T17:31:17Z","timestamp":1201023077000},"page":"595-603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Cardiovascular Safety of High Doses of Inhaled Fenoterol and Albuterol in Acute Severe Asthma"],"prefix":"10.1016","volume":"110","author":[{"given":"Michael T.","family":"Newhouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"McCallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja T.","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis M.","family":"Bowie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard V.","family":"Hodder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Par\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Mesic-Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor A.","family":"Molfino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.110.3.595_bib1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0140-6736(89)92505-1","article-title":"Prescribed fenoterol and death from asthma in New Zealand, 1981-83: case-control study","volume":"1","author":"Crane","year":"1989","journal-title":"Lancet"},{"key":"10.1378\/chest.110.3.595_bib2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/thx.45.3.170","article-title":"Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81","volume":"45","author":"Pearce","year":"1990","journal-title":"Thorax"},{"key":"10.1378\/chest.110.3.595_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/thx.46.2.105","article-title":"Prescribed fenoterol and death from asthma in New Zealand, 1981-7: a further case control study","volume":"46","author":"Grainger","year":"1991","journal-title":"Thorax"},{"key":"10.1378\/chest.110.3.595_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1056\/NEJM199101313240502","article-title":"Respiratory arrest in near-fatal asthma","volume":"324","author":"Molfino","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.110.3.595_bib5","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1136\/bmj.282.6280.1932","article-title":"Self-poisoning with oral salbutamol","volume":"282","author":"Prior","year":"1981","journal-title":"BMJ"},{"key":"10.1378\/chest.110.3.595_bib6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2125.1980.tb01776.x","article-title":"Comparative efficacy of salbutamol by pressurized aerosol and wet nebulizer in acute asthma","volume":"10","author":"Tarala","year":"1980","journal-title":"Br J Clin Pharmacol"},{"key":"10.1378\/chest.110.3.595_bib7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0091-6749(84)90413-5","article-title":"Effect of bronchodilator therapy administered by canister versus jet nebulizer","volume":"73","author":"Shim","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.110.3.595_bib8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1378\/chest.93.3.476","article-title":"Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction","volume":"93","author":"Turner","year":"1988","journal-title":"Chest"},{"issue":"suppl","key":"10.1378\/chest.110.3.595_bib9","first-page":"52S","article-title":"Metered dose inhaler with spacer is superior to wet nebulization for emergency room treatment of acute, severe asthma","volume":"94","author":"Hodder","year":"1988","journal-title":"Chest"},{"key":"10.1378\/chest.110.3.595_bib10","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1378\/chest.104.3.835","article-title":"A comparison of albuterol administered by metered dose inhaler (and holding chamber) or wet nebulizer in acute asthma","volume":"104","author":"Colacone","year":"1993","journal-title":"Chest"},{"key":"10.1378\/chest.110.3.595_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1164\/ajrccm\/136.1.225","article-title":"Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and Asthma","volume":"136","author":"American Thoracic Society Board of Directors","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.110.3.595_bib12","series-title":"Psycho-physical judgement and the process of perceptions: Proceedings of the 22nd International Congress of Psychology","first-page":"25","article-title":"A category scale with ratio properties for intermodal and interindividual comparisons","author":"Borg","year":"1980"},{"key":"10.1378\/chest.110.3.595_bib13","first-page":"353","article-title":"An analysis of the time relations of electrocardiograms","volume":"7","author":"Bazett","year":"1920","journal-title":"Heart"},{"key":"10.1378\/chest.110.3.595_bib14","series-title":"An introduction to electrocardiography","first-page":"141","article-title":"The Q-T interval","author":"Schamroth","year":"1982"},{"key":"10.1378\/chest.110.3.595_bib15","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1378\/chest.105.6.1738","article-title":"Dose-effect relationship of the \u03b2-agonists fenoterol and salbutamol in patients with asthma","volume":"105","author":"Newhouse","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.110.3.595_bib16","first-page":"239","article-title":"The cardiac tolerance of a beta2 sympathomimetic spray: fenoterol: a report on 37 cases assessed by Holter monitoring in a therapeutic trial with a short protocol","volume":"2","author":"Escamilla","year":"1985","journal-title":"Rev Mal Respir"},{"key":"10.1378\/chest.110.3.595_bib17","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1542\/peds.83.6.1023","article-title":"Severe acute asthma in a pediatric intensive care unit: 6 years\u2019 experience","volume":"83","author":"Stein","year":"1989","journal-title":"Pediatrics"},{"key":"10.1378\/chest.110.3.595_bib18","first-page":"162","article-title":"Decrease of plasma potassium due to inhalation of beta2-agonists: absence of an additional effect of intravenous theophylline","volume":"18","author":"Deenstra","year":"1988","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1378\/chest.110.3.595_bib19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF00558306","article-title":"A comparison of the extent and duration of hypokalaemia following three nebulized beta2-adrenoceptor agonists","volume":"36","author":"Burgess","year":"1989","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1378\/chest.110.3.595_bib20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0140-6736(85)92432-8","article-title":"Hypokalaemia induced by inhalation of fenoterol","volume":"1","author":"Haalboom","year":"1985","journal-title":"Lancet"},{"key":"10.1378\/chest.110.3.595_bib21","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(89)92769-4","article-title":"Fenoterol and serum potassium","volume":"1","author":"Martelli","year":"1989","journal-title":"Lancet"},{"key":"10.1378\/chest.110.3.595_bib22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2165\/00002018-199207010-00007","article-title":"Risks versus benefits of inhaled \u03b22-agonists in the management of asthma","volume":"7","author":"Lipworth","year":"1992","journal-title":"Drug Safety"},{"key":"10.1378\/chest.110.3.595_bib23","doi-asserted-by":"crossref","first-page":"23P","DOI":"10.1042\/cs068023P","article-title":"Tolerance to the unwanted effects of intravenous terbutaline after chronic oral dosing","volume":"68","author":"Smith","year":"1985","journal-title":"Clin Sci 68"},{"key":"10.1378\/chest.110.3.595_bib24","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/clpt.1982.102","article-title":"Extrapulmonary effect of terbutaline during prolonged administration","volume":"31","author":"Bengtsson","year":"1982","journal-title":"Clin Pharmacol Ther"},{"key":"10.1378\/chest.110.3.595_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0140-6736(89)90284-5","article-title":"Effect of fenoterol on plasma potassium and cardiac ectopic activity","volume":"2","author":"Haalboom","year":"1989","journal-title":"Lancet"},{"key":"10.1378\/chest.110.3.595_bib26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/clpt.1990.152","article-title":"The pulmonary and extrapulmonary effects of inhaled \u03b2-agonists in patients with asthma","volume":"48","author":"Windom","year":"1990","journal-title":"Clin Pharmacol Ther"},{"key":"10.1378\/chest.110.3.595_bib27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1378\/chest.103.3.665","article-title":"Emergency department treatment of severe asthma: metered-dose inhaler plus holding chamber is equivalent in effectiveness to nebulizer","volume":"103","author":"Idris","year":"1993","journal-title":"Chest"},{"key":"10.1378\/chest.110.3.595_bib28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1164\/ajrccm.150.3.8087354","article-title":"Proximate delivery of a large experimental dose from salbutamol MDI induces epithelial airway lesions in intubated rabbits","volume":"150","author":"Spahr-Schopfer","year":"1994","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216410573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216410573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:48:41Z","timestamp":1757922521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216410573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["S0012369216410573"],"URL":"https:\/\/doi.org\/10.1378\/chest.110.3.595","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1996,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular Safety of High Doses of Inhaled Fenoterol and Albuterol in Acute Severe Asthma","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.110.3.595","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}