{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:21:04Z","timestamp":1790508064923,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1997,1]]},"DOI":"10.1378\/chest.111.1.44","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T17:31:17Z","timestamp":1201023077000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Exhaled Nitric Oxide During Exercise in Primary Pulmonary Hypertension and Pulmonary Fibrosis"],"prefix":"10.1016","volume":"111","author":[{"given":"Marshall S.","family":"Riley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"P\u00f3rsz\u00f3sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00eblle P.K.J.","family":"Engelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlman","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Brundage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.111.1.44_bib1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1183\/09031936.94.07081501","article-title":"Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome","volume":"7","author":"Lundberg","year":"1994","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.111.1.44_bib2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nm0495-370","article-title":"High nitric oxide production in human paranasal sinuses","volume":"1","author":"Lundberg","year":"1995","journal-title":"Nature Med"},{"key":"10.1378\/chest.111.1.44_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/jappl.1995.78.1.59","article-title":"Exhaled nitric oxide in isolated pig lungs","volume":"78","author":"Cremona","year":"1995","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.111.1.44_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJM199507273330403","article-title":"Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension","volume":"333","author":"Giaid","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.111.1.44_bib6","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1164\/ajrccm\/145.5.1052","article-title":"Oxygen uptake kinetics in response to exercise in patients with pulmonary vascular disease","volume":"145","author":"Sietsema","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.111.1.44_bib7","series-title":"Principles of exercise testing and interpretation","author":"Wasserman","year":"1986"},{"key":"10.1378\/chest.111.1.44_bib8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(94)92047-8","article-title":"Increased nitric oxide production during exercise","volume":"343","author":"Matsumoto","year":"1994","journal-title":"Lancet"},{"key":"10.1378\/chest.111.1.44_bib9","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1152\/jappl.1981.51.6.1662","article-title":"Breath-by-breath measurement of true alveolar gas exchange","volume":"51","author":"Beaver","year":"1981","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.111.1.44_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(94)90931-8","article-title":"Increased nitric oxide in exhaled air of asthmatic patients","volume":"343","author":"Kharitonov","year":"1994","journal-title":"Lancet"},{"key":"10.1378\/chest.111.1.44_bib11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1748-1716.1990.tb09021.x","article-title":"Endogenous nitric oxide as a probable mediator of pulmonary circulation and hypoxic pressor response in vivo","volume":"140","author":"Persson","year":"1990","journal-title":"Acta Physiol Scand"},{"key":"10.1378\/chest.111.1.44_bib12","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1164\/ajrccm\/148.5.1210","article-title":"Endogenous nitric oxide in single exhalations and the change during exercise","volume":"148","author":"Persson","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.111.1.44_bib13","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1183\/09031936.93.06091368","article-title":"Increased amount of nitric oxide in exhaled air of asthmatics","volume":"6","author":"Alving","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.111.1.44_bib14","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0006-291X(91)91268-H","article-title":"Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans","volume":"181","author":"Gustafsson","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1378\/chest.111.1.44_bib15","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0140-6736(94)91465-6","article-title":"Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx","volume":"343","author":"Gerlach","year":"1994","journal-title":"Lancet"},{"key":"10.1378\/chest.111.1.44_bib16","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1152\/jappl.1993.75.6.2740","article-title":"Contribution of endothelium-derived relaxing factor to exercise-induced vasodilation in humans","volume":"75","author":"Wilson","year":"1993","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.111.1.44_bib17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/jphysiol.1957.sp005777","article-title":"The kinetics and equilibria of the reactions of nitric oxide with sheep hemoglobin","volume":"136","author":"Gibson","year":"1957","journal-title":"J Physiol"},{"key":"10.1378\/chest.111.1.44_bib18","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1073\/pnas.91.21.10089","article-title":"Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells","volume":"91","author":"Asano","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1378\/chest.111.1.44_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0140-6736(94)90935-0","article-title":"Single-breath nitric oxide measurements in asthmatic patients and smokers","volume":"343","author":"Persson","year":"1994","journal-title":"Lancet"},{"key":"10.1378\/chest.111.1.44_bib20","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.88.17.7797","article-title":"Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues","volume":"88","author":"Dawson","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1378\/chest.111.1.44_bib21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1183\/09031936.93.02010056","article-title":"A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide","volume":"2","author":"Borland","year":"1989","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.111.1.44_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1378\/chest.111.1.44_bib23","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1152\/jappl.1994.76.2.933","article-title":"Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypertensive rats","volume":"76","author":"Isaacson","year":"1994","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.111.1.44_bib24","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJM199105303242203","article-title":"Impairment of endothelium-dependent pulmonary artery relaxation in chronic obstructive pulmonary disease","volume":"324","author":"Dinh-Xuan","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.111.1.44_bib25","series-title":"Clinical respiratory physiology","author":"Taylor","year":"1989"},{"key":"10.1378\/chest.111.1.44_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0034-5687(94)90069-8","article-title":"Effect of graded exercise on nitric oxide in expired air in humans","volume":"97","author":"Iwamoto","year":"1994","journal-title":"Respir Physiol"},{"key":"10.1378\/chest.111.1.44_bib27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1378\/chest.69.2_Supplement.256-a","article-title":"Distribution of ventilation-perfusion ratios in patients with interstitial lung disease","volume":"69","author":"Wagner","year":"1976","journal-title":"Chest"},{"key":"10.1378\/chest.111.1.44_bib28","first-page":"547","article-title":"Mixed expired nitric oxide in primary pulmonary hypertension in relation to lung diffusing capacity","volume":"87","author":"Cremona","year":"1994","journal-title":"Q J Med"},{"key":"10.1378\/chest.111.1.44_bib29","first-page":"312","article-title":"Endogenous prostacyclin preserves myocardial function and endothelium-derived nitric oxide formation in myocardial ischemia","volume":"37","author":"Schror","year":"1992","journal-title":"Agents Actions Suppl"},{"key":"10.1378\/chest.111.1.44_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0014-2999(91)90362-T","article-title":"The calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries","volume":"197","author":"Vilaine","year":"1991","journal-title":"Eur J Pharmacol"},{"issue":"suppl 1","key":"10.1378\/chest.111.1.44_bib31","first-page":"I","article-title":"Exhaled nitric oxide is increased after exercise in congestive heart failure [abstract]","volume":"92","author":"Robbins","year":"1995","journal-title":"Circulation"},{"key":"10.1378\/chest.111.1.44_bib4","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1136\/thx.48.11.1160","article-title":"Measurement of exhaled nitric oxide in man","volume":"48","author":"Borland","year":"1993","journal-title":"Thorax"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215467765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215467765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:19:02Z","timestamp":1757920742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215467765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["S0012369215467765"],"URL":"https:\/\/doi.org\/10.1378\/chest.111.1.44","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exhaled Nitric Oxide During Exercise in Primary Pulmonary Hypertension and Pulmonary Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.111.1.44","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1378\/chest.111.1.4","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}