{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:28:19Z","timestamp":1775507299123,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1378\/chest.116.1.195","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"195-200","source":"Crossref","is-referenced-by-count":20,"title":["An In Vitro Comparison of the Mucoactive Properties of Guaifenesin, Iodinated Glycerol, Surfactant, and Albuterol"],"prefix":"10.1016","volume":"116","author":[{"given":"Bruce K.","family":"Rubin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.116.1.195_bib1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1378\/chest.106.5.1532","article-title":"Recommendations for guidelines on clinical trials of mucoactive drugs in chronic bronchitis and chronic obstructive pulmonary disease","volume":"106","author":"Task Group on Mucoactive Drugs","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.116.1.195_bib2","series-title":"The pediatric lung","first-page":"155","article-title":"Mucoactive agents: old and new","author":"Rubin","year":"1997"},{"key":"10.1378\/chest.116.1.195_bib3","series-title":"Acute respiratory failure in chronic obstructive pulmonary disease","first-page":"391","article-title":"Mucus physiology and pathophysiology: therapeutic aspects","author":"King","year":"1996"},{"key":"10.1378\/chest.116.1.195_bib4","series-title":"Airway secretion: physiological bases for the control of mucus hypersecretion","first-page":"283","article-title":"Mucus rheology, relationship with transport","author":"King","year":"1994"},{"key":"10.1378\/chest.116.1.195_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1378\/chest.63.1.9","article-title":"The expectorant effect of glyceryl guaiacolate in patients with chronic bronchitis: a controlled in vitro and in vivo study","volume":"63","author":"Hirsch","year":"1973","journal-title":"Chest"},{"key":"10.1378\/chest.116.1.195_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1378\/chest.109.2.348","article-title":"Iodinated glycerol has no effect on pulmonary function, symptom score, or sputum properties in patients with stable chronic bronchitis","volume":"109","author":"Rubin","year":"1996","journal-title":"Chest"},{"key":"10.1378\/chest.116.1.195_bib7","first-page":"130","article-title":"A superior iodide preparation for respiratory tract disease, iodopropylidene glycerol (Organidin)","volume":"10","author":"Seltzer","year":"1961","journal-title":"Med Ann DC"},{"key":"10.1378\/chest.116.1.195_bib8","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1001\/jama.1997.03550170056032","article-title":"Effects of aerosolized surfactant in patients with stable chronic bronchitis: a prospective randomized controlled trial","volume":"278","author":"Anzueto","year":"1997","journal-title":"JAMA"},{"key":"10.1378\/chest.116.1.195_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000194607","article-title":"Acute effect of inhaled salbutamol on mucociliary clearance in health and chronic bronchitis","volume":"45","author":"Lafortuna","year":"1984","journal-title":"Respiration"},{"key":"10.1378\/chest.116.1.195_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF01968821","article-title":"The actions of methacholine, phenylephrine, salbutamol and histamine on mucus secretion from the ferret in-vitro trachea","volume":"22","author":"Webber","year":"1987","journal-title":"Agents Actions"},{"key":"10.1378\/chest.116.1.195_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1164\/ajrccm\/136.1.225","article-title":"Standards for the diagnosis and care of patients with chronic obstructive lung disease (COPD) and asthma","volume":"136","author":"American Thoracic Society","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.116.1.195_bib12","first-page":"347","article-title":"Rheology of sputum collected by a simple technique limiting salivary contamination","volume":"103","author":"Puchelle","year":"1984","journal-title":"J Lab Clin Med"},{"key":"10.1378\/chest.116.1.195_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3233\/BIR-1973-10302","article-title":"The effect of freezing, storing, and thawing on the viscosity of sputum","volume":"10","author":"Charman","year":"1973","journal-title":"Biorheology"},{"key":"10.1378\/chest.116.1.195_bib14","first-page":"490","article-title":"Physical properties of sputum: V. The effects of time, freezing, and thawing on viscoelasticity measurements","volume":"109","author":"Adler","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.116.1.195_bib15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3233\/BIR-1989-26215","article-title":"Effect of air humidity on spinability and transport capacity of canine airway secretions","volume":"26","author":"Puchelle","year":"1989","journal-title":"Biorheology"},{"key":"10.1378\/chest.116.1.195_bib16","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3233\/BIR-1989-26602","article-title":"Mucus transport in a miniaturized simulated cough machine: effect of constriction and serous layer simulant","volume":"26","author":"Agarwal","year":"1989","journal-title":"Biorheology"},{"key":"10.1378\/chest.116.1.195_bib17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1152\/jappl.1990.69.2.424","article-title":"Mucus-depleted frog palate as a model for the study of mucociliary clearance","volume":"69","author":"Rubin","year":"1990","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.116.1.195_bib18","series-title":"Cilia, mucus, and mucociliary interactions","first-page":"317","article-title":"Surface properties of respiratory secretions: relationship to mucus transport","author":"Rubin","year":"1998"},{"key":"10.1378\/chest.116.1.195_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.1982.sp014143","article-title":"Water repellency induced by pulmonary surfactants","volume":"325","author":"Hills","year":"1982","journal-title":"J Physiol (Lond)"},{"key":"10.1378\/chest.116.1.195_bib20","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1152\/jappl.1996.81.6.2690","article-title":"Ring distraction technique for measuring the surface tension of sputum and relationship of the work of adhesion to clearability","volume":"81","author":"Albers","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.116.1.195_bib21","first-page":"249","article-title":"Relationship between mucus viscoelasticity and ciliary transport in guaran gel\/frog palate model system","volume":"17","author":"King","year":"1980","journal-title":"Biorheology"},{"key":"10.1378\/chest.116.1.195_bib22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1152\/jappl.1977.42.5.761","article-title":"Mucus clearance: in vivo canine tracheal versus in vitro bullfrog palate studies","volume":"42","author":"Giordano","year":"1977","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.116.1.195_bib23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0006-355X(95)92361-D","article-title":"Rheologic properties of airway secretions in cystic fibrosis, chronic bronchitis, and fatal asthma","volume":"32","author":"Tomkiewicz","year":"1995","journal-title":"Biorheology"},{"key":"10.1378\/chest.116.1.195_bib24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3233\/BIR-1989-26406","article-title":"The role of mucus gel viscosity, spinability, and adhesive properties in clearance by simulated cough","volume":"26","author":"King","year":"1989","journal-title":"Biorheology"},{"key":"10.1378\/chest.116.1.195_bib25","first-page":"441","article-title":"Influence of surfactant on mucociliary transport","volume":"19","author":"Allegra","year":"1985","journal-title":"Prog Respir Dis"},{"key":"10.1378\/chest.116.1.195_bib26","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1183\/09031936.93.06081156","article-title":"Distearoyl phosphatidylglycerol liposomes improve surface and transport properties of CF mucus","volume":"6","author":"Girod de Bentzmann","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.116.1.195_bib27","first-page":"121","article-title":"Evaluation of the elastic and viscous components of bronchial mucus before and after S-carboxymethylcysteine-Lys treatment","volume":"4","author":"Braga","year":"1984","journal-title":"Int J Clin Pharmacol Res"},{"key":"10.1378\/chest.116.1.195_bib28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/thx.30.6.669","article-title":"No demonstrable effect of S-carboxymethylcysteine on clearance of secretions from the human lung","volume":"30","author":"Thomson","year":"1975","journal-title":"Thorax"},{"key":"10.1378\/chest.116.1.195_bib29","first-page":"254","article-title":"Mucociliary transport in vivo and in vitro : relations to sputum properties in chronic bronchitis","volume":"61","author":"Puchelle","year":"1980","journal-title":"Eur J Respir Dis"},{"key":"10.1378\/chest.116.1.195_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000194301","article-title":"Tracheobronchial function in health and disease: effect of mucolytic substances","volume":"40","author":"Melville","year":"1980","journal-title":"Respiration"},{"key":"10.1378\/chest.116.1.195_bib31","first-page":"1901","article-title":"Effect of bronchodilation on the deposition and clearance of radioaerosol in bronchial asthma in remission","volume":"28","author":"Isawa","year":"1987","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.1.195_bib32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1164\/ajrccm\/141.3.715","article-title":"Does a beta 2 stimulator really facilitate mucociliary transport in the human lungs in vivo ? A study with procaterol","volume":"141","author":"Isawa","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.116.1.195_bib33","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ppul.1950100415","article-title":"Recurrent respiratory infections in a child with fucosidosis: is the mucus too thin for effective transport?","volume":"10","author":"Rubin","year":"1991","journal-title":"Pediatr Pulmonol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215381733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215381733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T22:09:22Z","timestamp":1734041362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215381733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["S0012369215381733"],"URL":"https:\/\/doi.org\/10.1378\/chest.116.1.195","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}