{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:47:00Z","timestamp":1791017220931,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1378\/chest.116.6.1575","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"1575-1581","source":"Crossref","is-referenced-by-count":25,"title":["Abnormality of Left Ventricular Sympathetic Nervous Function Assessed by 123I-Metaiodobenzylguanidine Imaging in Patients With COPD"],"prefix":"10.1016","volume":"116","author":[{"given":"Fumio","family":"Sakamaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritoshi","family":"Nagaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kyotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.116.6.1575_bib1","first-page":"21","article-title":"On bronchial contraction","volume":"6","author":"Roy","year":"1885","journal-title":"J Physiol"},{"key":"10.1378\/chest.116.6.1575_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0954-6111(06)80098-3","article-title":"The parasympathetic nervous system and the diurnal variation of lung mechanism in asthma","volume":"85","author":"Morrison","year":"1991","journal-title":"Respir Med"},{"key":"10.1378\/chest.116.6.1575_bib3","first-page":"620","article-title":"Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate","volume":"10","author":"Hirsch","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1378\/chest.116.6.1575_bib4","first-page":"1289","article-title":"Neuronal control of human airways in health and disease","volume":"134","author":"Barnes","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.116.6.1575_bib5","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1183\/09031936.93.04101207","article-title":"Cardiovascular autonomic nerve function in patients with hypoxaemic chronic obstructive pulmonary disease","volume":"4","author":"Stewart","year":"1991","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.116.6.1575_bib6","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1378\/chest.106.5.1432","article-title":"Decreased heart rate variability in patients with chronic obstructive pulmonary disease","volume":"106","author":"Volterrani","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.116.6.1575_bib7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1378\/chest.113.2.327","article-title":"Heart rate variability reflects severity of COPD in PiZ \u03b11-antitrypsin deficiency","volume":"113","author":"Stein","year":"1998","journal-title":"Chest"},{"key":"10.1378\/chest.116.6.1575_bib8","first-page":"567","article-title":"Assessment of cardiac sympathetic function with iodine-123-MIBG imaging in obstructive sleep apnea syndrome","volume":"38","author":"Otsuka","year":"1997","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.6.1575_bib9","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1056\/NEJM197108122850710","article-title":"The left ventricle in \u201cchronic bronchitis and emphysema.\u201d","volume":"285","author":"Fishman","year":"1971","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.116.6.1575_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1378\/chest.97.2.453","article-title":"The heart is not always in good hands","volume":"97","author":"Butler","year":"1990","journal-title":"Chest"},{"key":"10.1378\/chest.116.6.1575_bib11","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.CIR.74.6.1290","article-title":"Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down regulation and subsensitivity to agonist response","volume":"74","author":"Fowler","year":"1986","journal-title":"Circulation"},{"key":"10.1378\/chest.116.6.1575_bib12","first-page":"349","article-title":"Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with I-131 iodobenzylguanidine","volume":"21","author":"Wieland","year":"1980","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.6.1575_bib13","first-page":"22","article-title":"Myocardial imaging with a radioiodinated norepinephrine storage analog","volume":"22","author":"Wieland","year":"1981","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.6.1575_bib14","first-page":"1444","article-title":"Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts: implications for clinical studies","volume":"33","author":"Dae","year":"1992","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.6.1575_bib15","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/0735-1097(89)90391-4","article-title":"Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123 metaiodobenzylguanidine","volume":"14","author":"Stanton","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.116.6.1575_bib16","first-page":"57","article-title":"Myocardial uptake of metaiodobenzylguanidine in patients with left ventricular hypertrophy secondary to valvular aortic stenosis","volume":"34","author":"Fagret","year":"1993","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.6.1575_bib17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/01.CIR.78.5.1192","article-title":"Abnormal I-123 metaiodobenzylguanidine myocardial washout and distribution may reflect myocardial adrenergic derangement in patients with congestive cardiomyopathy","volume":"78","author":"Henderson","year":"1988","journal-title":"Circulation"},{"key":"10.1378\/chest.116.6.1575_bib18","first-page":"471","article-title":"Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure","volume":"33","author":"Merlet","year":"1992","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.6.1575_bib19","first-page":"1182","article-title":"Iodine-123 metaiodobenzylguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac tranplants","volume":"30","author":"Glowniak","year":"1989","journal-title":"J Nucl Med"},{"key":"10.1378\/chest.116.6.1575_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00006231-199405000-00003","article-title":"Decreased123I-MIBG uptake and increased clearance in various cardiac diseases","volume":"15","author":"Nakajima","year":"1994","journal-title":"Nucl Med Commun"},{"key":"10.1378\/chest.116.6.1575_bib21","series-title":"Fishman's pulmonary diseases and disorders","article-title":"Approach to the patient with respiratory symptoms","author":"Fishman","year":"1998"},{"key":"10.1378\/chest.116.6.1575_bib22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry: 1994 update; ATS statement","volume":"152","author":"American Thoracic Society","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.116.6.1575_bib23","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI105803","article-title":"Left ventricular function in patients with chronic obstructive pulmonary disease","volume":"47","author":"Williams","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.116.6.1575_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1378\/chest.58.1.8","article-title":"Left ventricular function in cor pulmonale","volume":"58","author":"Davies","year":"1970","journal-title":"Chest"},{"key":"10.1378\/chest.116.6.1575_bib25","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1378\/chest.113.3.576","article-title":"Right and left ventricular dysfunction in patients with severe pulmonary disease","volume":"113","author":"Vizza","year":"1998","journal-title":"Chest"},{"key":"10.1378\/chest.116.6.1575_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0002-9343(68)90041-7","article-title":"Left ventricular failure secondary to chronic pulmonary disease","volume":"45","author":"Rao","year":"1968","journal-title":"Am J Med"},{"key":"10.1378\/chest.116.6.1575_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1056\/NEJM197108122850701","article-title":"Left ventricular function in chronic obstructive lung disease","volume":"285","author":"Baum","year":"1971","journal-title":"N Engl J Med"},{"issue":"suppl I","key":"10.1378\/chest.116.6.1575_bib28","first-page":"13","article-title":"Sympathetic dysregulation in heart failure: mechanisms and therapy","volume":"18","author":"Mark","year":"1995","journal-title":"Clin Cardiol"},{"key":"10.1378\/chest.116.6.1575_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0002-9343(83)91127-0","article-title":"Role of beta-adrenergic blockade in the therapy of patients with myocardial infarction","volume":"74","author":"Braunwald","year":"1983","journal-title":"Am J Med"},{"key":"10.1378\/chest.116.6.1575_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/eurheartj\/4.suppl_A.173","article-title":"Beta-blockers in dilated cardiomyopathies: they work","volume":"4","author":"Waagstein","year":"1983","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.116.6.1575_bib31","first-page":"1343","article-title":"Iodine-123-metaiodobenzylguanidine myocardial imaging in patients with right ventricular pressure overload","volume":"37","author":"Morimitsu","year":"1996","journal-title":"J Nucl Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216369987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216369987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T12:00:25Z","timestamp":1682510425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216369987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0012369216369987"],"URL":"https:\/\/doi.org\/10.1378\/chest.116.6.1575","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}