{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T20:05:34Z","timestamp":1766347534459},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1378\/chest.117.5.1319","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"1319-1323","source":"Crossref","is-referenced-by-count":21,"title":["The Protective Effect of Salbutamol Inhaled Using Different Devices on Methacholine Bronchoconstriction"],"prefix":"10.1016","volume":"117","author":[{"given":"Daniele","family":"Giannini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Di Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Lorenzo","family":"Dente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Taccola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Vagaggini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Paggiaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.117.5.1319_bib1","series-title":"Global strategy for asthma management and prevention: NHBLI workshop report","year":"1995"},{"key":"10.1378\/chest.117.5.1319_bib2","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1183\/09031936.97.10092127","article-title":"Airway deposition and airway effects of antiasthma drugs delivered from metered-dose inhalers","volume":"10","author":"Pauwels","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.117.5.1319_bib3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/jps.2600810807","article-title":"Pulmonary deposition of inhaled terbutaline: comparison of scanning gamma camera and urinary excretion methods","volume":"81","author":"Borgstrom","year":"1992","journal-title":"J Pharm Sci"},{"key":"10.1378\/chest.117.5.1319_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1016278926231","article-title":"Comparison of gamma camera scintigraphy and pharmacokinetic technique for assessing pulmonary deposition of terbutaline sulphate delivered by pressurized metered-dose inhaler","volume":"12","author":"Newman","year":"1995","journal-title":"Pharm Res"},{"key":"10.1378\/chest.117.5.1319_bib5","first-page":"317","article-title":"Deposition of pressurized suspension aerosols inhaled through extension devices","volume":"124","author":"Newman","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.117.5.1319_bib6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/thx.46.10.712","article-title":"Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique","volume":"46","author":"Newman","year":"1991","journal-title":"Thorax"},{"key":"10.1378\/chest.117.5.1319_bib7","first-page":"81","article-title":"The effect of powder aerosol compared to pressurized aerosol","volume":"63","author":"Svedmyr","year":"1982","journal-title":"Eur J Respir Dis"},{"key":"10.1378\/chest.117.5.1319_bib8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2222.1977.tb01486.x","article-title":"Comparison of salbutamol Rotahaler with conventional pressurized aerosol","volume":"7","author":"Hetzel","year":"1977","journal-title":"Clin Allergy"},{"key":"10.1378\/chest.117.5.1319_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000196047","article-title":"Comparative assessment of a new breath-actuated inhaler in patients with reversible airways obstruction","volume":"59","author":"Waterhouse","year":"1992","journal-title":"Respiration"},{"key":"10.1378\/chest.117.5.1319_bib10","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1183\/09031936.97.10112474","article-title":"Difference in bronchodilating potency of salbutamol in Turbuhaler\u00aeas compared with a pressurized metered-dose inhaler formulation in patients with reversible airway obstruction","volume":"10","author":"Lofdahl","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.117.5.1319_bib11","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1164\/ajrccm.153.5.8630614","article-title":"The inhalation device influences lung deposition and bronchodilating effect of terbutaline","volume":"153","author":"Borgstrom","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.117.5.1319_bib12","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1183\/09031936.97.10081824","article-title":"Comparative efficacy and potency of ipratropium via Turbuhaler\u00aeand pressurized metered-dose inhaler in reversible airflow obstruction","volume":"10","author":"Bollert","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.117.5.1319_bib13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/thx.43.4.300","article-title":"Dose related effects of salbutamol and ipratropium bromide on airway calibre and reactivity in subjects with asthma","volume":"43","author":"Britton","year":"1988","journal-title":"Thorax"},{"key":"10.1378\/chest.117.5.1319_bib14","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1164\/ajrccm\/136.4_Pt_2.S64","article-title":"Effect of beta-agonists and anticholinergic drugs on bronchial reactivity","volume":"136","author":"Tattersfield","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.117.5.1319_bib15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/thx.32.4.429","article-title":"Protective effect of drugs on histamine-induced asthma","volume":"32","author":"Cockcroft","year":"1977","journal-title":"Thorax"},{"key":"10.1378\/chest.117.5.1319_bib16","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0091-6749(76)90207-4","article-title":"The effect of atropine and albuterol aerosols on the human bronchial response to histamine","volume":"58","author":"Casterline","year":"1976","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.117.5.1319_bib17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1183\/09031936.97.10020330","article-title":"Effects of long-acting and short-acting \u03b2-agonists on methacholine dose-response curves in asthmatics","volume":"10","author":"Wong","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.117.5.1319_bib18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0954-6111(98)90312-2","article-title":"The bronchoprotective efficacy of salbutamol inhaled from a new metered-dose powder inhaler compared with a conventional pressurized metered-dose inhaler connected to a spacer","volume":"92","author":"Seppala","year":"1998","journal-title":"Respir Med"},{"key":"10.1378\/chest.117.5.1319_bib19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1378\/chest.103.4.1123","article-title":"Bronchial hyperresponsiveness and toluene diisocyanate: long-term change in sensitized asthmatic subjects","volume":"103","author":"Paggiaro","year":"1993","journal-title":"Chest"},{"key":"10.1378\/chest.117.5.1319_bib20","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1056\/NEJM199210223271704","article-title":"Tolerance to the nonbronchodilator effects of inhaled \u03b22-agonists in asthma","volume":"327","author":"O'Connor","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.117.5.1319_bib21","series-title":"Statistical methods in medical research","author":"Armitage","year":"1994"},{"key":"10.1378\/chest.117.5.1319_bib22","series-title":"Nonparametrics statistics for the behavioral sciences","author":"Siegel","year":"1992"},{"key":"10.1378\/chest.117.5.1319_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0954-6111(95)90085-3","article-title":"Determining equivalence of inhaled medications","volume":"89","author":"Rogers","year":"1995","journal-title":"Respir Med"},{"key":"10.1378\/chest.117.5.1319_bib24","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1183\/09031936.94.07091707","article-title":"Multiple actuations of salbutamol MDI into spacer devices reduce the amount of drug recovered in the respirable range","volume":"84","author":"Barry","year":"1994","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.117.5.1319_bib25","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1136\/thx.49.11.1162","article-title":"Volumatic usage: some generic salbutamol metered dose inhalers can be used","volume":"49","author":"Chege","year":"1994","journal-title":"Thorax"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215350911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215350911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T20:28:54Z","timestamp":1553113734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215350911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["S0012369215350911"],"URL":"https:\/\/doi.org\/10.1378\/chest.117.5.1319","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}