{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:43:42Z","timestamp":1781700222291,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1378\/chest.117.6.1577","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"1577-1582","source":"Crossref","is-referenced-by-count":39,"title":["Clinical Predictors of N2 Disease in Non-small Cell Lung Cancer"],"prefix":"10.1016","volume":"117","author":[{"given":"Kazuya","family":"Takamochi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanji","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Ohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Nishiwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.117.6.1577_bib1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0039-6109(16)44340-9","article-title":"Evaluation of the mediastinum by invasive techniques","volume":"67","author":"Ginsberg","year":"1987","journal-title":"Surg Clin North Am"},{"key":"10.1378\/chest.117.6.1577_bib2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0003-4975(10)60348-7","article-title":"Role of mediastinoscopy in pretreatment staging of patients with primary lung cancer","volume":"40","author":"Coughlin","year":"1985","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.117.6.1577_bib3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0022-5223(19)35330-9","article-title":"The value of mediastinoscopy in preoperative staging of bronchogenic carcinoma","volume":"97","author":"Van Schil","year":"1989","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0022-5223(19)34164-9","article-title":"N2 lung cancer: outcome in patients with false-negative computed tomographic scans of the chest","volume":"105","author":"Daly","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/1010-7940(94)90131-7","article-title":"Value of computed tomography and mediastinoscopy in preoperative evaluation of mediastinal nodes in non-small cell lung cancer: a study of 569 patients","volume":"8","author":"Dillemans","year":"1994","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1378\/chest.117.6.1577_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0022-5223(19)36410-4","article-title":"Selective preoperative evaluation for possible N2 disease in carcinoma of the lung","volume":"93","author":"Backer","year":"1987","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib7","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0022-5223(19)38282-0","article-title":"Computed tomography: an effective technique for mediastinal staging in lung cancer","volume":"88","author":"Daly","year":"1984","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0003-4975(10)62241-2","article-title":"Computed tomography for evaluation of mediastinal lymph nodes in lung cancer: correlation with surgical staging","volume":"38","author":"Breyer","year":"1984","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.117.6.1577_bib9","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2214\/ajr.142.6.1101","article-title":"The mediastinum in non-small cell lung cancer: CT-surgical correlation","volume":"142","author":"Glazer","year":"1984","journal-title":"AJR Am J Roentgenol"},{"key":"10.1378\/chest.117.6.1577_bib10","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0022-5223(19)36178-1","article-title":"Mediastinal lymph node evaluation by computed tomography in lung cancer: an analysis of 345 patients grouped by TNM staging, tumor size, and tumor location","volume":"94","author":"Daly","year":"1987","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1164\/ajrccm\/141.5_Pt_1.1096","article-title":"Computed tomography to stage lung cancer: approaching a controversy using meta-analysis","volume":"141","author":"Dales","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.117.6.1577_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0022-5223(19)38985-8","article-title":"TNM staging in lung cancer: role of computed tomography","volume":"84","author":"Modini","year":"1982","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2214\/ajr.143.4.715","article-title":"Mediastinal lymph node size in lung cancer","volume":"143","author":"Libshitz","year":"1984","journal-title":"AJR Am J Roentgenol"},{"key":"10.1378\/chest.117.6.1577_bib14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1148\/radiology.156.2.4011889","article-title":"Oblique hilar tomography, computed tomography, and mediastinoscopy for prethoracotomy staging of bronchogenic carcinoma","volume":"156","author":"Khan","year":"1985","journal-title":"Radiology"},{"key":"10.1378\/chest.117.6.1577_bib15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0022-5223(19)38529-0","article-title":"Comparative merits of conventional, computed tomographic, and magnetic resonance imaging in assessing mediastinal involvement in surgically confirmed lung carcinoma","volume":"90","author":"Martini","year":"1985","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1378\/chest.88.2.206","article-title":"Roentgenographic evaluation of mediastinal nodes for preoperative assessment in lung cancer","volume":"88","author":"McKenna","year":"1985","journal-title":"Chest"},{"key":"10.1378\/chest.117.6.1577_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-5223(19)36317-2","article-title":"Computed tomography for the evaluation of intrathoracic invasion by lung cancer","volume":"94","author":"Rendina","year":"1987","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1148\/radiology.142.1.7053525","article-title":"Comparison of plain radiography, conventional tomography, and computed tomography in detecting intrathoracic lymph node metastases from lung carcinoma","volume":"142","author":"Osborne","year":"1982","journal-title":"Radiology"},{"key":"10.1378\/chest.117.6.1577_bib19","first-page":"111","article-title":"Histological typing of lung tumours","volume":"29","author":"World Health Organization","year":"1982","journal-title":"Neoplasma"},{"key":"10.1378\/chest.117.6.1577_bib20","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1378\/chest.111.6.1710","article-title":"Revisions in the International System for Staging Lung Cancer","volume":"111","author":"Mountain","year":"1997","journal-title":"Chest"},{"key":"10.1378\/chest.117.6.1577_bib21","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0022-5223(19)39559-5","article-title":"Lymph node mapping and curability at various levels of metastasis in resected lung cancer","volume":"76","author":"Naruke","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-5223(94)70447-3","article-title":"Surgical management of non-small-cell lung cancer with ipsilateral mediastinal node metastasis (N2 disease)","volume":"107","author":"Goldstraw","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0003-4975(89)90115-X","article-title":"Preoperative chemotherapy and irradiation for stage III non-small cell lung cancer","volume":"47","author":"Faber","year":"1989","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.117.6.1577_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1056\/NEJM199401203300301","article-title":"A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer","volume":"330","author":"Rosell","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.117.6.1577_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-5002(98)00046-4","article-title":"Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer","volume":"21","author":"Roth","year":"1998","journal-title":"Lung Cancer"},{"key":"10.1378\/chest.117.6.1577_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1148\/radiology.166.1.3336704","article-title":"Bronchogenic carcinoma metastatic to normal-sized lymph nodes: frequency and significance","volume":"166","author":"Gross","year":"1988","journal-title":"Radiology"},{"key":"10.1378\/chest.117.6.1577_bib27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0022-5223(99)70340-5","article-title":"Clinical predictors of N2 disease in the setting of a negative computed tomographic scan in patients with lung cancer","volume":"117","author":"Suzuki","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0022-5223(96)70213-1","article-title":"Lymph node involvement, recurrence, and prognosis in resected small, peripheral, non-small-cell lung carcinomas: are these carcinomas candidates for video-assisted lobectomy?","volume":"111","author":"Asamura","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0022-5223(98)70127-8","article-title":"Lymph node metastasis in small peripheral adenocarcinoma of the lung","volume":"116","author":"Takizawa","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.117.6.1577_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/bjc.1981.164","article-title":"Carcinoembryonic antigen and prognosis after radical surgery for lung cancer: immunocytochemical localization and serum levels","volume":"44","author":"Ford","year":"1981","journal-title":"Br J Cancer"},{"key":"10.1378\/chest.117.6.1577_bib31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0007-0971(80)90075-3","article-title":"Preoperative carcinoembryonic antigen and survival after resection of lung cancer","volume":"74","author":"Stokes","year":"1980","journal-title":"Br J Dis Chest"},{"key":"10.1378\/chest.117.6.1577_bib32","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/1097-0142(197809)42:3+<1477::AID-CNCR2820420818>3.0.CO;2-E","article-title":"Prognostic value of preoperative carcinoembryonic antigen (CEA) plasma levels in patients with bronchogenic carcinoma","volume":"42","author":"Concannon","year":"1978","journal-title":"Cancer"},{"key":"10.1378\/chest.117.6.1577_bib33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0022-5223(98)70007-8","article-title":"Serum carcinoembryonic antigen as an adjunct to preoperative staging of lung cancer","volume":"116","author":"Rubins","year":"1998","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215351473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215351473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T17:12:10Z","timestamp":1584810730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215351473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0012369215351473"],"URL":"https:\/\/doi.org\/10.1378\/chest.117.6.1577","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}