{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:04:37Z","timestamp":1791482677444,"version":"4.3.4"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1378\/chest.118.2.290","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"290-295","source":"Crossref","is-referenced-by-count":84,"title":["Unpredictability of Deception in Compliance With Physician-Prescribed Bronchodilator Inhaler Use in a Clinical Trial"],"prefix":"10.1016","volume":"118","author":[{"given":"Michael S.","family":"Simmons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell A.","family":"Nides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Rand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Tashkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.118.2.290_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0091-6749(86)90325-8","article-title":"Compliance of patients with asthma with an experimental aerosolized medication: implications for controlled clinical trials","volume":"77","author":"Spector","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.118.2.290_bib2","first-page":"119","article-title":"What is wrong with home blood glucose monitoring? Use of memory meters in problem patients in a diabetes outpatient clinic","volume":"1","author":"Petranyi","year":"1988","journal-title":"Diabetes Nutr Metab"},{"key":"10.1378\/chest.118.2.290_bib3","first-page":"294","article-title":"Compliance in clinical trials of two nonbronchodilator, antiasthma medications","volume":"66","author":"Mawhinney","year":"1991","journal-title":"Ann Allergy"},{"key":"10.1378\/chest.118.2.290_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/adc.67.3.332","article-title":"Measuring compliance with inhaled medication in asthma","volume":"67","author":"Coutts","year":"1992","journal-title":"Arch Dis Child"},{"key":"10.1378\/chest.118.2.290_bib5","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1164\/ajrccm\/146.6.1559","article-title":"Metered-dose inhaler adherence in a clinical trial","volume":"146","author":"Rand","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.118.2.290_bib6","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1200\/JCO.1993.11.6.1189","article-title":"Adherence to oral tamoxifen: a comparison of patient self-report, pill counts, and microelectronic monitoring","volume":"11","author":"Waterhouse","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.118.2.290_bib7","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0091-6749(96)80190-4","article-title":"Noncompliance and treatment failure in children with asthma","volume":"98","author":"Milgrom","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.118.2.290_bib8","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archinte.1990.00390190143023","article-title":"Compliance declines between clinic visits","volume":"150","author":"Cramer","year":"1990","journal-title":"Arch Intern Med"},{"key":"10.1378\/chest.118.2.290_bib9","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1378\/chest.109.4.963","article-title":"Trends in compliance with bronchodilator inhaler use between follow-up visits in a clinical trial","volume":"109","author":"Simmons","year":"1996","journal-title":"Chest"},{"issue":"Suppl A","key":"10.1378\/chest.118.2.290_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/eurheartj\/17.suppl_A.21","article-title":"Therapeutic implications of drug \u201cholidays.\u201d","volume":"17","author":"Meredith","year":"1996","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.118.2.290_bib11","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1001\/jama.1989.03420220087032","article-title":"How often is medication taken as prescribed? A novel assessment technique","volume":"261","author":"Cramer","year":"1989","journal-title":"JAMA"},{"key":"10.1378\/chest.118.2.290_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/clpt.1989.122","article-title":"The natural history of medication compliance in a drug trial: limitations of pill counts","volume":"46","author":"Rudd","year":"1989","journal-title":"Clin Pharmacol Therap"},{"key":"10.1378\/chest.118.2.290_bib13","series-title":"Patient compliance in medical practice and clinical trials","first-page":"149","article-title":"Aerosol inhaler monitoring of asthmatic children","author":"Spector","year":"1991"},{"key":"10.1378\/chest.118.2.290_bib14","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1001\/jama.1994.03520190043033","article-title":"Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: The Lung Health Study","volume":"272","author":"Anthonisen","year":"1994","journal-title":"JAMA"},{"issue":"2S","key":"10.1378\/chest.118.2.290_bib15","first-page":"1","article-title":"Design of the Lung Health Study: a randomized clinical trial of early intervention for chronic obstructive pulmonary disease","volume":"14","author":"Connett","year":"1993","journal-title":"Controlled Clin Trials"},{"key":"10.1378\/chest.118.2.290_bib16","article-title":"SAS\/Stat Users Guide","volume":"Vol 1,2","year":"1990"},{"key":"10.1378\/chest.118.2.290_bib17","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1164\/ajrccm.152.2.7633711","article-title":"Long-term metered-dose inhaler adherence in a clinical trial","volume":"152","author":"Rand","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.118.2.290_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/02770909309066381","article-title":"As-needed medication use in asthma: usage patterns and patient characteristics","volume":"30","author":"Mawhinney","year":"1993","journal-title":"J Asthma"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215517820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215517820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T20:21:34Z","timestamp":1553113294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215517820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S0012369215517820"],"URL":"https:\/\/doi.org\/10.1378\/chest.118.2.290","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}