{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:15:02Z","timestamp":1774124102526,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1378\/chest.118.5.1294","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"1294-1302","source":"Crossref","is-referenced-by-count":142,"title":["The Spirometric Efficacy of Once-Daily Dosing With Tiotropium in Stable COPD"],"prefix":"10.1016","volume":"118","author":[{"given":"Richard","family":"Casaburi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Dick D.","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Donohue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles W.","family":"Serby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailendra S.","family":"Menjoge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Theodore J.","family":"Witek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.118.5.1294_bib1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1183\/09031936.95.08081398","article-title":"Optimal assessment and management of chronic obstructive pulmonary disease (COPD)","volume":"8","author":"Siafakas","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.118.5.1294_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1056\/NEJM199304083281408","article-title":"Management of chronic obstructive pulmonary disease","volume":"328","author":"Ferguson","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.118.5.1294_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1056\/NEJM198808253190806","article-title":"Ipratropium bromide","volume":"319","author":"Gross","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.118.5.1294_bib4","series-title":"Respiratory care pharmacology and therapeutics","author":"Witek","year":"1994"},{"key":"10.1378\/chest.118.5.1294_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF02718145","article-title":"The role of anticholinergic bronchodilators in adult asthma and COPD","volume":"168","author":"Chapman","year":"1990","journal-title":"Lung"},{"key":"10.1378\/chest.118.5.1294_bib6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0024-3205(93)90312-Q","article-title":"Ba 679 Br, a novel anticholinergic bronchodilator: predicted and clinical aspects","volume":"52","author":"Disse","year":"1993","journal-title":"Life Sci"},{"key":"10.1378\/chest.118.5.1294_bib7","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1164\/ajrccm.150.6.7952627","article-title":"Effect of Ba 679 Br: a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways","volume":"150","author":"Takahaski","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.118.5.1294_bib8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0024-3205(95)00020-7","article-title":"Tiotropium bromide (Ba 679 Br), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease","volume":"56","author":"Barnes","year":"1995","journal-title":"Life Sci"},{"key":"10.1378\/chest.118.5.1294_bib9","series-title":"Anticholinergic agents in the upper and lower airways","first-page":"137","article-title":"Tiotropium (Ba 679): pharmacology and early clinical observations","author":"Witek","year":"1999"},{"key":"10.1378\/chest.118.5.1294_bib10","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1183\/09031936.95.08091506","article-title":"Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: a pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD)","volume":"8","author":"Maesen","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.118.5.1294_bib11","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1183\/09031936.93.06071031","article-title":"Ba 679 Br, a new long-acting antimuscarinic bronchodilator: a pilot dose-escalation study","volume":"6","author":"Maesen","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.118.5.1294_bib12","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1164\/ajrccm.161.4.9903044","article-title":"Long-acting bronchodilation with once daily dosing of tiotropium (Spiriva) in stable COPD","volume":"161","author":"Littner","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"suppl","key":"10.1378\/chest.118.5.1294_bib13","first-page":"S77","article-title":"Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD)","volume":"152","author":"American Thoracic Society","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.118.5.1294_bib14","first-page":"A524","article-title":"Effective use of the HandiHaler dry powder inhalation system over a broad range of COPD disease severity [abstract]","volume":"159","author":"Chodosh","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.118.5.1294_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1378\/chest.93.1.123","article-title":"Fifteen year interval spirometric evaluation of the Oregon predictive equations","volume":"93","author":"Morris","year":"1988","journal-title":"Chest"},{"key":"10.1378\/chest.118.5.1294_bib16","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry: 1994 update","volume":"152","author":"American Thoracic Society","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.118.5.1294_bib17","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1378\/chest.115.4.966","article-title":"The combination of ipratropium and albuterol optimizes pulmonary function reversibility testing in patients with COPD","volume":"115","author":"Dorinsky","year":"1999","journal-title":"Chest"},{"key":"10.1378\/chest.118.5.1294_bib18","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1378\/chest.115.4.957","article-title":"Efficacy of salmeterol xinafoate in the treatment of COPD","volume":"115","author":"Mahler","year":"1999","journal-title":"Chest"},{"key":"10.1378\/chest.118.5.1294_bib19","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/arrd.1986.133.1.14","article-title":"Bronchodilator response in chronic obstructive pulmonary disease","volume":"133","author":"Anthonisen","year":"1986","journal-title":"Am Rev Respir Dis"},{"issue":"suppl","key":"10.1378\/chest.118.5.1294_bib20","first-page":"S1","article-title":"British Thoracic Society guidelines for the management of chronic obstructive pulmonary disease","volume":"52","author":"The COPD Guidelines Group of the Standard of Care Committee of the British Thoracic Society","year":"1997","journal-title":"Thorax"},{"issue":"28","key":"10.1378\/chest.118.5.1294_bib21","first-page":"A1S","article-title":"The onset of spirometric response following once daily inhalation of tiotropium in patients with COPD [abstract]","volume":"12","author":"Van Noord","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.118.5.1294_bib22","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1378\/chest.105.5.1411","article-title":"In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone","volume":"105","author":"Combivent Inhalation Aerosol Study Group","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.118.5.1294_bib23","first-page":"286","article-title":"The efficacy and safety of combination bronchodilator therapy","volume":"6","author":"Wilson","year":"1996","journal-title":"Eur Respir Rev"},{"key":"10.1378\/chest.118.5.1294_bib24","first-page":"A525","article-title":"Superior efficacy of tiotropium (TIO) compared to ipratropium (IpBr) as a maintenance bronchodilator in COPD [abstract]","volume":"159","author":"Van Noord","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.118.5.1294_bib25","series-title":"Respiratory care clinics of North America","first-page":"521","article-title":"Anticholinergic bronchodilators","author":"Witek","year":"1999"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215512002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215512002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:02:38Z","timestamp":1704844958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215512002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["S0012369215512002"],"URL":"https:\/\/doi.org\/10.1378\/chest.118.5.1294","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}