{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:28:30Z","timestamp":1771363710791,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1378\/chest.119.5.1480","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"1480-1488","source":"Crossref","is-referenced-by-count":70,"title":["Efficacy of IV The ophylline in Children With Severe Status Asthmaticus"],"prefix":"10.1016","volume":"119","author":[{"given":"Robert S.","family":"Ream","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Loftis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary M.","family":"Albers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley A.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Mink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.119.5.1480_bib1","first-page":"135","article-title":"Successful treatment of persistent extreme dyspnea \u201cstatus asthmaticus\u201d: use of the ophylline ethylene diamine (aminophylline, U.S.P.) intravenously","volume":"23","author":"Herrmann","year":"1937","journal-title":"J Lab Clin Med"},{"key":"10.1378\/chest.119.5.1480_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00063198-200001000-00014","article-title":"Management of respiratory failure in patients with asthma","volume":"6","author":"Gluckman","year":"2000","journal-title":"Curr Opin Pulm Med"},{"key":"10.1378\/chest.119.5.1480_bib3","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1542\/peds.48.4.642","article-title":"Double-blind trial of aminophylline in status asthmaticus","volume":"48","author":"Pierson","year":"1971","journal-title":"Pediatrics"},{"key":"10.1378\/chest.119.5.1480_bib4","first-page":"181","article-title":"The ophylline serum concentration and the rapeutic effect in severe acute bronchial obstruction: the optimal use of intravenously administered aminophylline","volume":"125","author":"Vozeh","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.119.5.1480_bib5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJM198408093110601","article-title":"Effects of the ophylline on diaphragmatic strength and fatigue in patients with chronic obstructive pulmonary disease","volume":"311","author":"Murciano","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.119.5.1480_bib6","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1152\/jappl.1988.64.4.1445","article-title":"Ventilatory response to sustained hypoxia after pretreatment with aminophylline","volume":"64","author":"Easton","year":"1988","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.119.5.1480_bib7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1378\/chest.88.2.194","article-title":"Aerosol penetration and mucociliary transport in the healthy human lung: effect of low serum the ophylline levels","volume":"88","author":"Cotromanes","year":"1985","journal-title":"Chest"},{"key":"10.1378\/chest.119.5.1480_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2500\/108854189778960090","article-title":"Antidiuretic hormone in acute asthma in children: effects of medication on serum levels and clinical course","volume":"10","author":"Iikura","year":"1989","journal-title":"Allergy Proc"},{"key":"10.1378\/chest.119.5.1480_bib9","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0140-6736(94)90127-9","article-title":"Anti-inflammatory effects of low-dose oral the ophylline in atopic asthma","volume":"343","author":"Sullivan","year":"1994","journal-title":"Lancet"},{"key":"10.1378\/chest.119.5.1480_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-3476(05)80423-8","article-title":"Safety and efficacy of the ophylline in children with asthma","volume":"120","author":"Hendeles","year":"1992","journal-title":"J Pediatr"},{"key":"10.1378\/chest.119.5.1480_bib11","first-page":"365","article-title":"Emergency therapy of asthma: comparison of the acute effects of parenteral and inhaled sympathomimetics and infused aminophylline","volume":"122","author":"Rossing","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.119.5.1480_bib12","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1542\/peds.92.5.666","article-title":"Safety of continuous nebulized albuterol for bronchospasm in infants and children","volume":"92","author":"Katz","year":"1993","journal-title":"Pediatrics"},{"key":"10.1378\/chest.119.5.1480_bib13","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1097\/00003246-199810000-00033","article-title":"Continuous intravenous terbutaline for pediatric status asthmaticus","volume":"26","author":"Stephanopoulos","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.119.5.1480_bib14","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.7326\/0003-4819-119-12-199312150-00001","article-title":"Does aminophylline benefit adults admitted to the hospital for an acute exacerbation of asthma?","volume":"119","author":"Huang","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.119.5.1480_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1183\/09031936.95.08010028","article-title":"Gas exchange response to intravenous aminophylline in patients with a severe exacerbation of asthma","volume":"8","author":"Montserrat","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.119.5.1480_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7326\/0003-4819-115-4-241","article-title":"Aminophylline therapy for acute bronchospastic disease in the emergency room","volume":"115","author":"Wrenn","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.119.5.1480_bib17","first-page":"283","article-title":"Aminophylline increases the toxicity but not the efficacy of an inhaled \u03b2-adrenergic agonist in the treatment of acute exacerbations of asthma","volume":"132","author":"Siegel","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.119.5.1480_bib18","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1378\/chest.98.6.1317","article-title":"Inhaled albuterol and oral prednisone therapy in hospitalized adult asthmatics: does aminophylline add any benefit?","volume":"98","author":"Self","year":"1990","journal-title":"Chest"},{"key":"10.1378\/chest.119.5.1480_bib19","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1001\/archinte.1993.00410150062006","article-title":"Aminophylline in the treatment of acute asthma when \u03b22-adrenergics and steroids are provided","volume":"153","author":"Murphy","year":"1993","journal-title":"Arch Intern Med"},{"key":"10.1378\/chest.119.5.1480_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/thx.49.3.267","article-title":"Effect of adding aminophylline infusion to nebulised salbutamol in severe acute asthma","volume":"49","author":"Zainudin","year":"1994","journal-title":"Thorax"},{"key":"10.1378\/chest.119.5.1480_bib21","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1378\/chest.106.4.1071","article-title":"Treatment of acute asthma: lack of the rapeutic benefit and increase of the toxicity from aminophylline given in addition to high doses of salbutamol by metered-dose inhaler with a spacer","volume":"106","author":"Rodrigo","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.119.5.1480_bib22","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-3476(05)83442-0","article-title":"Hospital treatment of asthma: lack of benefit from the ophylline given in addition to nebulized albuterol and intravenously administered corticosteroid","volume":"122","author":"Digiulio","year":"1993","journal-title":"J Pediatr"},{"key":"10.1378\/chest.119.5.1480_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0022-3476(05)83443-2","article-title":"Efficacy of intravenously the ophylline in children hospitalized with severe asthma","volume":"122","author":"Carter","year":"1993","journal-title":"J Pediatr"},{"key":"10.1378\/chest.119.5.1480_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1542\/peds.93.2.205","article-title":"Aminophylline therapy does improve outcome and increases adverse effects in children hospitalized with acute asthmatic exacerbations","volume":"93","author":"Strauss","year":"1994","journal-title":"Pediatrics"},{"key":"10.1378\/chest.119.5.1480_bib25","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archpedi.1995.02170140088016","article-title":"The ophylline does not shorten hospital stay for children admitted for asthma","volume":"149","author":"Needleman","year":"1995","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1378\/chest.119.5.1480_bib26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/000992289503400905","article-title":"Intravenous the ophylline in pediatric status asthmaticus: a prospective, randomized, double-blind, placebo-controlled trial","volume":"34","author":"Bien","year":"1995","journal-title":"Clin Pediatr"},{"key":"10.1378\/chest.119.5.1480_bib27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1081-1206(10)62990-0","article-title":"Efficacy of aminophylline in the treatment of acute asthma exacerbation in children","volume":"80","author":"Nuhoglu","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1378\/chest.119.5.1480_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0272-0590(81)80025-5","article-title":"Enhancement of cardiotoxic effects of \u03b2-adrenergic bronchodilators by aminophylline in experimental animals","volume":"1","author":"Joseph","year":"1981","journal-title":"Fundam Appl Toxicol"},{"key":"10.1378\/chest.119.5.1480_bib29","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/0091-6749(86)90065-5","article-title":"Adverse effects of the ophylline-\u03b2 agonist interactions","volume":"78","author":"Nicklas","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.119.5.1480_bib30","unstructured":"National Asthma Education and Prevention Program. Expert panel report 2: guidelines for the diagnosis and management of asthma. Bethesda, MD: National Institutes of Health, 1997; Publication No. 051; 115\u2013117"},{"key":"10.1378\/chest.119.5.1480_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/archpedi.154.3.287","article-title":"Prevalence, impact, and trends in childhood disability because of asthma","volume":"154","author":"Newacheck","year":"2000","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1378\/chest.119.5.1480_bib32","unstructured":"Centers for Disease Control and Prevention. Asthma mortality and hospitalization among children and young adults-United States, 1980\u20131993. MMWR Morb Mortal Wkly Rep 1996; 45: 350\u2013353"},{"key":"10.1378\/chest.119.5.1480_bib33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1542\/peds.101.5.845","article-title":"Adverse asthma outcomes among children hospitalized with asthma in California","volume":"101","author":"Calmes","year":"1998","journal-title":"Pediatrics"},{"key":"10.1378\/chest.119.5.1480_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archpedi.1972.02110090097011","article-title":"A clinical scoring system for the diagnosis of respiratory failure","volume":"123","author":"Wood","year":"1972","journal-title":"Am J Dis Child"},{"key":"10.1378\/chest.119.5.1480_bib35","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1097\/00003246-199310000-00015","article-title":"A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children","volume":"21","author":"Papo","year":"1993","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.119.5.1480_bib36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0895-4356(94)90211-9","article-title":"Clinical scores for acute asthma in pre-school children: a review of the literature","volume":"47","author":"Van Der Windt","year":"1994","journal-title":"J Clin Epidemiol"},{"key":"10.1378\/chest.119.5.1480_bib37","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/00003246-198811000-00006","article-title":"Pediatric risk of mortality (PRISM) score","volume":"16","author":"Pollack","year":"1988","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.119.5.1480_bib38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/adc.79.5.405","article-title":"Randomised controlled trial of aminophylline for severe acute asthma","volume":"79","author":"Yung","year":"1998","journal-title":"Arch Dis Child"},{"key":"10.1378\/chest.119.5.1480_bib39","first-page":"190","article-title":"A controlled trial of the use of single versus combined drug therapy in the treatment of acute episodes of asthma","volume":"123","author":"Rossing","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.119.5.1480_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0002-9343(86)90041-0","article-title":"Treatment of acute asthma: is combination therapy with sympathomimetics and methylxanthines indicated?","volume":"80","author":"Fanta","year":"1986","journal-title":"Am J Med"},{"key":"10.1378\/chest.119.5.1480_bib41","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/thx.52.12.1036","article-title":"Effects of airway calibre on lung delivery of nebulized salbutamol","volume":"52","author":"Lipworth","year":"1997","journal-title":"Thorax"},{"key":"10.1378\/chest.119.5.1480_bib42","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1651-2227.1993.tb12609.x","article-title":"Systemic absorption of salbutamol after nebulizer delivery in acute asthma","volume":"82","author":"Penna","year":"1993","journal-title":"Acta Paediatr"},{"key":"10.1378\/chest.119.5.1480_bib43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0025-6196(11)63701-4","article-title":"The ophylline: recent advances in the understanding of its mode of action and uses in clinical practice","volume":"73","author":"Vassallo","year":"1998","journal-title":"Mayo Clin Proc"},{"key":"10.1378\/chest.119.5.1480_bib44","first-page":"23","article-title":"In vivo desensitization to \u03b2 receptor mediated bronchodilator drugs in the rat: decreased \u03b2 receptor affinity","volume":"207","author":"Avner","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1378\/chest.119.5.1480_bib45","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/thx.36.10.741","article-title":"Intravenous salbutamol and aminophylline in asthma: a search for synergy","volume":"36","author":"Handslip","year":"1981","journal-title":"Thorax"},{"key":"10.1378\/chest.119.5.1480_bib46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0163-7258(96)00119-2","article-title":"Potential role of adenosine antagonist therapy in pathological tremor disorders","volume":"72","author":"Mally","year":"1996","journal-title":"Pharmacol Ther"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215396100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215396100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T22:10:43Z","timestamp":1734041443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215396100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["S0012369215396100"],"URL":"https:\/\/doi.org\/10.1378\/chest.119.5.1480","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}