{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:55:58Z","timestamp":1791226558846,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Novartis in 2010 toward development of clinical services at the University Hospital of South Manchester","award":["grant of \u00a310,000"],"award-info":[{"award-number":["grant of \u00a310,000"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1378\/chest.12-0872","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T17:01:21Z","timestamp":1370538081000},"page":"406-414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype"],"prefix":"10.1016","volume":"143","author":[{"given":"David","family":"Gibeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannangara","family":"Batuwita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Osmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam G.","family":"Heaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris E.","family":"Brightling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Niven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Bucknall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj K","family":"Bhavsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Fan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Menzies-Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1378\/chest.12-0872_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1513\/pats.200903-013ST","article-title":"An official American Thoracic Society Workshop report: obesity and asthma","volume":"7","author":"Dixon","year":"2010","journal-title":"Proc Am Thorac Soc"},{"issue":"1","key":"10.1378\/chest.12-0872_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pharmthera.2005.10.002","article-title":"Obesity and asthma","volume":"110","author":"Shore","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"7","key":"10.1378\/chest.12-0872_bib3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1164\/rccm.200611-1717OC","article-title":"Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies","volume":"175","author":"Beuther","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1378\/chest.12-0872_bib4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jaci.2004.11.050","article-title":"The epidemiology of obesity and asthma","volume":"115","author":"Ford","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1378\/chest.12-0872_bib5","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1183\/09031936.00192408","article-title":"Body mass index as predictor for asthma: a cohort study of 118,723 males and females","volume":"35","author":"Hjellvik","year":"2010","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.12-0872_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/thx.2007.082784","article-title":"Body mass index and asthma severity in the National Asthma Survey","volume":"63","author":"Taylor","year":"2008","journal-title":"Thorax"},{"issue":"5","key":"10.1378\/chest.12-0872_bib7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1081\/JAS-120037651","article-title":"Relationship between asthma severity and obesity","volume":"41","author":"Akerman","year":"2004","journal-title":"J Asthma"},{"issue":"2","key":"10.1378\/chest.12-0872_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1152\/japplphysiol.00847.2006","article-title":"Obesity and asthma: lessons from animal models","volume":"102","author":"Shore","year":"2007","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1378\/chest.12-0872_bib9","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2008.03.004","article-title":"Obesity and asthma: possible mechanisms","volume":"121","author":"Shore","year":"2008","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1378\/chest.12-0872_bib10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/rccm.200711-1754OC","article-title":"Cluster analysis and clinical asthma phenotypes","volume":"178","author":"Haldar","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1378\/chest.12-0872_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1183\/09031936.06.00077205","article-title":"Influence of body mass index on the response to asthma controller agents","volume":"27","author":"Peters-Golden","year":"2006","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.12-0872_bib12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2500\/aap.2010.31.3307","article-title":"Comparative effect of body mass index on response to asthma controller therapy","volume":"31","author":"Sutherland","year":"2010","journal-title":"Allergy Asthma Proc"},{"issue":"7","key":"10.1378\/chest.12-0872_bib13","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1016\/j.rmed.2007.06.031","article-title":"Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma","volume":"101","author":"Boulet","year":"2007","journal-title":"Respir Med"},{"issue":"7","key":"10.1378\/chest.12-0872_bib14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.200801-076OC","article-title":"Body mass and glucocorticoid response in asthma","volume":"178","author":"Sutherland","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1378\/chest.12-0872_bib15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/thx.2010.137414","article-title":"Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry","volume":"65","author":"Heaney","year":"2010","journal-title":"Thorax"},{"issue":"6","key":"10.1378\/chest.12-0872_bib16","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1164\/ajrccm.162.6.ats9-00","article-title":"Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions","volume":"162","author":"American Thoracic Society","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.12-0872_bib17","author":"The NHS Information Centre"},{"issue":"1","key":"10.1378\/chest.12-0872_bib18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1081-1206(10)61707-3","article-title":"Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma","volume":"92","author":"Dolan","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"10.1378\/chest.12-0872_bib19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1183\/09031936.03.00261903","article-title":"The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma","volume":"22","author":"European Network for Understanding Mechanisms of Severe Asthma","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.12-0872_bib20","author":"Asthma UK"},{"issue":"7557","key":"10.1378\/chest.12-0872_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/bmj.38840.608704.80","article-title":"Smoking, obesity, and their co-occurrence in the United States: cross sectional analysis","volume":"333","author":"Healton","year":"2006","journal-title":"BMJ"},{"issue":"2","key":"10.1378\/chest.12-0872_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000330900","article-title":"The impact of cigarette smoking on asthma: a population-based international cohort study","volume":"158","author":"Cerveri","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1378\/chest.12-0872_bib23","author":"Action On Smoking and Health"},{"issue":"5","key":"10.1378\/chest.12-0872_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1467-789X.2011.00969.x","article-title":"Gastrointestinal symptoms and obesity: a meta-analysis","volume":"13","author":"Eslick","year":"2012","journal-title":"Obes Rev"},{"issue":"2","key":"10.1378\/chest.12-0872_bib25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jaci.2006.11.639","article-title":"Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program","volume":"119","author":"Moore","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1378\/chest.12-0872_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/jama.290.1.66","article-title":"Obesity and estrogen as risk factors for gastroesophageal reflux symptoms","volume":"290","author":"Nilsson","year":"2003","journal-title":"JAMA"},{"issue":"6","key":"10.1378\/chest.12-0872_bib27","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0002-9343(99)00121-7","article-title":"Risk factors associated with symptoms of gastroesophageal reflux","volume":"106","author":"Locke","year":"1999","journal-title":"Am J Med"},{"issue":"5","key":"10.1378\/chest.12-0872_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1164\/rccm.200802-301OC","article-title":"The association between obesity and asthma: interactions between systemic and airway inflammation","volume":"178","author":"Sutherland","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1378\/chest.12-0872_bib29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200906-0896OC","article-title":"Identification of asthma phenotypes using cluster analysis in the severe asthma research program","volume":"181","author":"Moore","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1378\/chest.12-0872_bib30","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2133.2011.10694.x","article-title":"Association between atopic dermatitis and obesity in adulthood","volume":"166","author":"Silverberg","year":"2012","journal-title":"Br J Dermatol"},{"issue":"6","key":"10.1378\/chest.12-0872_bib31","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1742-1241.2009.02301.x","article-title":"Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index","volume":"64","author":"Greco","year":"2010","journal-title":"Int J Clin Pract"},{"issue":"11","key":"10.1378\/chest.12-0872_bib32","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1503\/cmaj.081332","article-title":"Overdiagnosis of asthma in obese and nonobese adults","volume":"179","author":"Aaron","year":"2008","journal-title":"CMAJ"},{"issue":"5","key":"10.1378\/chest.12-0872_bib33","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1378\/chest.107.5.1298","article-title":"The effect of body fat distribution on pulmonary function tests","volume":"107","author":"Collins","year":"1995","journal-title":"Chest"},{"issue":"6","key":"10.1378\/chest.12-0872_bib34","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.jaci.2011.03.036","article-title":"Obesity and asthma: an association modified by age of asthma onset","volume":"127","author":"Holguin","year":"2011","journal-title":"J Allergy Clin Immunol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369213600884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369213600884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:33:50Z","timestamp":1757918030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369213600884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0012369213600884"],"URL":"https:\/\/doi.org\/10.1378\/chest.12-0872","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity-Associated Severe Asthma Represents a Distinct Clinical Phenotype","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.12-0872","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}