{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:33:00Z","timestamp":1793046780702,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1378\/chest.120.4.1226","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"1226-1230","source":"Crossref","is-referenced-by-count":65,"title":["Plasma Markers of Endothelial Dysfunction in Pulmonary Hypertension"],"prefix":"10.1016","volume":"120","author":[{"given":"Giuseppe","family":"Cella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bellotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Sbarai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Mazzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Fareed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.120.4.1226_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM199207093270209","article-title":"Endothelial dysfunction in pulmonary hypertension","volume":"327","author":"Loscalzo","year":"1992","journal-title":"N Engl J Med"},{"issue":"suppl","key":"10.1378\/chest.120.4.1226_bib2","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1378\/chest.105.2_Supplement.7S","article-title":"Pathophysiology of pulmonary hypertension: a role of endothelial dysfunction","volume":"105","author":"Higenbottam","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.120.4.1226_bib3","series-title":"Heart disease","first-page":"780","article-title":"Pulmonary hypertension","author":"Rich","year":"1997"},{"key":"10.1378\/chest.120.4.1226_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00001721-199803000-00001","article-title":"Altered hemostasis in pulmonary hypertension","volume":"9","author":"Hassel","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1378\/chest.120.4.1226_bib5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0022-2143(99)90094-X","article-title":"Prothrombotic mechanism in primary pulmonary hypertension","volume":"134","author":"Farber","year":"1999","journal-title":"J Lab Clin Med"},{"key":"10.1378\/chest.120.4.1226_bib6","first-page":"757","article-title":"Endothelial modulation of pulmonary vascular tone","volume":"5","author":"Dinh-Xuan","year":"1992","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.120.4.1226_bib7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-0038-1655981","article-title":"Anticoagulant property of the vascular endothelium","volume":"77","author":"Bombeli","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1378\/chest.120.4.1226_bib8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0735-1097(99)00259-4","article-title":"Assessment and treatment of endothelial dysfunction in humans","volume":"34","author":"Anderson","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.120.4.1226_bib9","first-page":"147","article-title":"Evidence for local platelet activation in pulmonary vessels in patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease","volume":"4","author":"Rostagno","year":"1991","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.120.4.1226_bib10","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1378\/chest.104.6.1690","article-title":"Platelet activation and fibrinopeptide formation in pulmonary hypertension","volume":"104","author":"Shulman","year":"1993","journal-title":"Chest"},{"key":"10.1378\/chest.120.4.1226_bib11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1378\/chest.110.3.710","article-title":"Coagulation and fibrinolytic profiles in patients with severe pulmonary hypertension","volume":"110","author":"Welsh","year":"1996","journal-title":"Chest"},{"key":"10.1378\/chest.120.4.1226_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0002-9343(96)80070-2","article-title":"Plasma levels of thrombomodulin in pulmonary hypertension","volume":"101","author":"Cacoub","year":"1996","journal-title":"Am J Med"},{"key":"10.1378\/chest.120.4.1226_bib13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(96)68012-4","article-title":"Colorimetric assays for nitric oxide and nitric oxide species formed from nitric oxide stock solutions and donor compounds","volume":"268","author":"Nims","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1378\/chest.120.4.1226_bib14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-2007-996080","article-title":"Endothelial cells-associated tissue factor pathway inhibitor (TFPI) antigen in severe non-diabetic obese patients: effect of hyperinsulinemia","volume":"23","author":"Cella","year":"1997","journal-title":"Semim Thromb Hemost"},{"key":"10.1378\/chest.120.4.1226_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/107602969900500109","article-title":"Soluble plasma thrombomodulin levels in patients with myeloproliferative disorder","volume":"5","author":"Randi","year":"1999","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1378\/chest.120.4.1226_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/107602960000600204","article-title":"Soluble P-Selectin in human plasma: effect of anticoagulant matrix and its levels in patients with cardiovascular disorders","volume":"6","author":"Amin","year":"2000","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1378\/chest.120.4.1226_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/clc.4960190706","article-title":"Coagulation and fibrinolytic parameters in patients with pulmonary hypertension","volume":"19","author":"Altman","year":"1996","journal-title":"Clin Cardiol"},{"key":"10.1378\/chest.120.4.1226_bib18","first-page":"L614","article-title":"Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension","volume":"262","author":"Stelzner","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1378\/chest.120.4.1226_bib19","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1161\/01.CIR.92.6.1539","article-title":"Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension","volume":"92","author":"Mehta","year":"1995","journal-title":"Circulation"},{"key":"10.1378\/chest.120.4.1226_bib20","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/thx.52.12.1051","article-title":"Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension","volume":"52","author":"Kharitonov","year":"1997","journal-title":"Thorax"},{"key":"10.1378\/chest.120.4.1226_bib21","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(98)09057-6","article-title":"Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: a case-cohort study","volume":"353","author":"Salomaa","year":"1999","journal-title":"Lancet"},{"key":"10.1378\/chest.120.4.1226_bib22","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/S0140-6736(05)75842-6","article-title":"Soluble thrombomodulin as predictor of incident coronary heart disease","volume":"354","author":"Cella","year":"1999","journal-title":"Lancet"},{"key":"10.1378\/chest.120.4.1226_bib23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1096\/fasebj.9.10.7542213","article-title":"The selectins: vascular adhesion molecules","volume":"9","author":"Tedder","year":"1995","journal-title":"FASEB J"},{"key":"10.1378\/chest.120.4.1226_bib24","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259","article-title":"Selectins and their ligands: current concepts and controversies","volume":"88","author":"Kansas","year":"1996","journal-title":"Blood"},{"key":"10.1378\/chest.120.4.1226_bib25","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1182\/blood.V83.6.1535.1535","article-title":"Plasma P-selectin is increased in thrombotic consumptive platelet disorders","volume":"83","author":"Chong","year":"1994","journal-title":"Blood"},{"key":"10.1378\/chest.120.4.1226_bib26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00001721-199710000-00002","article-title":"Increased soluble P-selectin following myocardial infarction: a new marker for the progression of atherosclerosis","volume":"78","author":"Blann","year":"1997","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"suppl","key":"10.1378\/chest.120.4.1226_bib27","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1177\/107602969900500108","article-title":"Selectins in the HIT syndrome: pathophysiologic role and therapeutic modulation","volume":"5","author":"Fareed","year":"1999","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1378\/chest.120.4.1226_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-2141.2000.01813.x","article-title":"Increased soluble P-selectin levels following deep venous thrombosis: cause or effect?","volume":"108","author":"Blann","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1378\/chest.120.4.1226_bib29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: a perspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1378\/chest.120.4.1226_bib30","first-page":"1427","article-title":"Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions","volume":"141","author":"van der Wal","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1378\/chest.120.4.1226_bib31","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1161\/01.CIR.95.8.2027","article-title":"The white blood cell adhesion molecule E-selectin predicts restenosis in patients with intermittent claudication undergoing percutaneous transmural angioplasty","volume":"95","author":"Belch","year":"1997","journal-title":"Circulation"},{"key":"10.1378\/chest.120.4.1226_bib32","first-page":"109","article-title":"Nitric oxide physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"issue":"suppl","key":"10.1378\/chest.120.4.1226_bib33","first-page":"154","article-title":"Tissue factor pathway inhibitor (TFPI): an update","volume":"26","author":"Sandset","year":"1996","journal-title":"Haemostasis"},{"key":"10.1378\/chest.120.4.1226_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1055\/s-0038-1651613","article-title":"Distribution of tissue factor pathway inhibitor in normal and malignant human tissues","volume":"69","author":"Werling","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1378\/chest.120.4.1226_bib35","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1055\/s-0038-1653884","article-title":"Sites of tissue factor pathway inhibitor (TFPI) and tissue factor expression under physiologic and pathologic conditions","volume":"73","author":"Osterud","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1378\/chest.120.4.1226_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-2007-996069","article-title":"Tissue factor pathway inhibitor (TFPI) antigen plasma level in patients with interstitial lung disease before and after heparin administration","volume":"23","author":"Cella","year":"1997","journal-title":"Semin Thromb Hemost"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216355301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216355301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T17:41:07Z","timestamp":1584812467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216355301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S0012369216355301"],"URL":"https:\/\/doi.org\/10.1378\/chest.120.4.1226","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}