{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:43:39Z","timestamp":1792608219741,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1378\/chest.120.4.1231","type":"journal-article","created":{"date-parts":[[2003,6,14]],"date-time":"2003-06-14T00:09:19Z","timestamp":1055549359000},"page":"1231-1238","source":"Crossref","is-referenced-by-count":157,"title":["Obesity Hypoventilation Syndrome as a Spectrum of Respiratory Disturbances During Sleep"],"prefix":"10.1016","volume":"120","author":[{"given":"Kenneth I.","family":"Berger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Ayappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Chatr-amontri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurva","family":"Marfatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Barry","family":"Sorkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta M.","family":"Goldring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.120.4.1231_bib1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0002-9343(56)90094-8","article-title":"Extreme obesity associated with alveolar hypoventilation: a pickwickian syndrome","volume":"21","author":"Burwell","year":"1956","journal-title":"Am J Med"},{"key":"10.1378\/chest.120.4.1231_bib2","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1172\/JCI103206","article-title":"Clinical and physiological aspects of a case of obesity, polycythemia, and alveolar hypoventilation","volume":"35","author":"Auchincloss","year":"1955","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.120.4.1231_bib3","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research","volume":"22","author":"American Academy of Sleep Medicine","year":"1999","journal-title":"Sleep"},{"key":"10.1378\/chest.120.4.1231_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.181.4102.856","article-title":"Insomnia with sleep apnea: a new syndrome","volume":"181","author":"Guilleminault","year":"1973","journal-title":"Science"},{"key":"10.1378\/chest.120.4.1231_bib5","series-title":"The heart and lung in obesity","first-page":"147","article-title":"Obesity and sleep-disordered breathing","author":"Koenig","year":"1998"},{"key":"10.1378\/chest.120.4.1231_bib6","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJM198210073071507","article-title":"Reversal of the \u201cpickwickian syndrome\u201d by long-term use of nocturnal nasal-airway pressure","volume":"307","author":"Rapoport","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.120.4.1231_bib7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1378\/chest.89.5.627","article-title":"Hypercapnia in the obstructive sleep apnea syndrome: a reevaluation of the \u201cpickwickian syndrome.\u201d","volume":"89","author":"Rapoport","year":"1986","journal-title":"Chest"},{"key":"10.1378\/chest.120.4.1231_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1164\/arrd.1983.128.1.177","article-title":"Remission of severe obesity-hypoventilation syndrome after short-term treatment during sleep with nasal continuous positive airway pressure","volume":"128","author":"Sullivan","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.120.4.1231_bib9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0140-6736(81)92140-1","article-title":"Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares","volume":"1","author":"Sullivan","year":"1981","journal-title":"Lancet"},{"key":"10.1378\/chest.120.4.1231_bib10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1164\/ajrccm.150.2.8049832","article-title":"Flow limitation as a noninvasive assessment of residual upper-airway resistance during continuous positive airway pressure therapy of obstructive sleep apnea","volume":"150","author":"Condos","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.120.4.1231_bib11","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1164\/ajrccm.157.5.9708008","article-title":"Detection of flow limitation with a nasal cannula\/pressure transducer system","volume":"157","author":"Hosselet","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.120.4.1231_bib12","first-page":"1175","article-title":"Detection of respiratory events during NPSG: nasal cannula\/pressure sensor versus thermistor","volume":"20","author":"Norman","year":"1997","journal-title":"Sleep"},{"key":"10.1378\/chest.120.4.1231_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/ajrccm.155.1.9001314","article-title":"Evaluation of nasal prongs for estimating nasal flow","volume":"155","author":"Montserrat","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.120.4.1231_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/imj.1967.16.1.20","article-title":"A clinical method for assessing the ventilatory response to carbon dioxide","volume":"16","author":"Read","year":"1967","journal-title":"Australas Ann Med"},{"key":"10.1378\/chest.120.4.1231_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0034-5687(75)90059-6","article-title":"Occlusion pressure as a measure of respiratory center output in conscious man","volume":"23","author":"Whitelaw","year":"1975","journal-title":"Respir Physiol"},{"key":"10.1378\/chest.120.4.1231_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1152\/jappl.1990.69.2.617","article-title":"Effects of sleep-induced increases in upper airway resistance on ventilation","volume":"69","author":"Henke","year":"1990","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.120.4.1231_bib17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1378\/chest.106.2.472","article-title":"Accuracy of end-tidal and transcutaneous Pco2 monitoring during sleep","volume":"106","author":"Sanders","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.120.4.1231_bib18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/ajrccm\/145.1.220","article-title":"Noninvasive assessment of blood gases","volume":"145","author":"Clark","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.120.4.1231_bib19","first-page":"144","article-title":"Time course of change in ventilatory response to CO2 with long-term CPAP therapy for obstructive sleep apnea","volume":"135","author":"Berthon-Jones","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.120.4.1231_bib20","first-page":"14","article-title":"Progressive improvement of apnea index and ventilatory response to CO2 after tracheostomy in obstructive sleep apnea syndrome","volume":"126","author":"Guilleminault","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.120.4.1231_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0002-9343(74)90135-1","article-title":"Current concepts in the pathogenesis of the obesity hypoventilation syndrome: mechanical and circulatory factors","volume":"57","author":"Rochestor","year":"1974","journal-title":"Am J Med"},{"key":"10.1378\/chest.120.4.1231_bib22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00000441-197503000-00001","article-title":"Regulation of alveolar ventilation in respiratory failure","volume":"269","author":"Goldring","year":"1975","journal-title":"Am J Med Sci"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216355313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216355313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T20:00:25Z","timestamp":1553112025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216355313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S0012369216355313"],"URL":"https:\/\/doi.org\/10.1378\/chest.120.4.1231","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}