{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:32:49Z","timestamp":1787243569012,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1378\/chest.121.1.292","type":"journal-article","created":{"date-parts":[[2003,6,13]],"date-time":"2003-06-13T20:09:19Z","timestamp":1055534959000},"page":"292-295","source":"Crossref","is-referenced-by-count":23,"title":["Human Recombinant Activated Protein C in Meningococcal Sepsis"],"prefix":"10.1016","volume":"121","author":[{"given":"Gregory","family":"Wcisel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arna","family":"Gudmundsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Michael","family":"Shasby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.121.1.292_bib1","series-title":"Scientific American medicine","article-title":"Sepsis","author":"Opal","year":"1998"},{"key":"10.1378\/chest.121.1.292_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"10.1378\/chest.121.1.292_bib3","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signalling in C3H\/HeJ and C57BL\/10ScCr Mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1378\/chest.121.1.292_bib4","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1001\/jama.1993.03510080079035","article-title":"Pathogenesis of disseminated intravascular coagulation in sepsis","volume":"270","author":"Levi","year":"1993","journal-title":"JAMA"},{"key":"10.1378\/chest.121.1.292_bib5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.7326\/0003-4819-67-2-250","article-title":"Intravascular coagulation in fulminant meningococcemia","volume":"67","author":"McGehee","year":"1967","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.121.1.292_bib6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/clinids\/17.2.254","article-title":"Epidemic meningococcemia and purpura fulminans with induced protein C deficiency","volume":"17","author":"Powers","year":"1993","journal-title":"Clin Infect Dis"},{"key":"10.1378\/chest.121.1.292_bib7","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1056\/NEJM199111283252207","article-title":"Treatment of homozygous protein C deficiency and neonatal purpura fulminans with protein C concentrate","volume":"325","author":"Dreyfus","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.121.1.292_bib8","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0140-6736(97)06356-3","article-title":"Use of protein C concentrate, heparin, and haemodialfiltration in meningococcus-induced purpura fulminans","volume":"350","author":"Smith","year":"1997","journal-title":"Lancet"},{"key":"10.1378\/chest.121.1.292_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0022-3476(66)80250-0","article-title":"Factors in the prognosis of meningococcal infection","volume":"68","author":"Stiehm","year":"1966","journal-title":"J Pediatr"},{"key":"10.1378\/chest.121.1.292_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00003246-199101000-00010","article-title":"Validation of the Glascow Meningococcal Septicemia Prognostic Score: a 10-year retrospective survey","volume":"19","author":"Thomson","year":"1991","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.121.1.292_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0038-1651669","article-title":"Coagulation activation and tissue necrosis in meningococcal septic shock: severely reduced protein C levels predict a high mortality","volume":"73","author":"Fijnvandraat","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1378\/chest.121.1.292_bib12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1378\/chest.101.3.816","article-title":"Septic shock, multiple organ failure and disseminated intravascular coagulation: compared patterns of antithrombin III, protein C and protein S deficiencies","volume":"101","author":"Fourrier","year":"1992","journal-title":"Chest"},{"issue":"suppl 3","key":"10.1378\/chest.121.1.292_bib13","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1007\/PL00014354","article-title":"Systemic meningococcal infection: which children may benefit from adjuvant haemostatic therapy? Results from an observational study","volume":"158","author":"Nurnberger","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1378\/chest.121.1.292_bib14","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1182\/blood.V96.12.3719","article-title":"An open-label study of hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia","volume":"96","author":"White","year":"2000","journal-title":"Blood"},{"key":"10.1378\/chest.121.1.292_bib15","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1001\/archinte.159.19.2329","article-title":"Meningococcal disease in a large urban population (Barcelona, 1987\u20131992)","volume":"159","author":"Barquet","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1378\/chest.121.1.292_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/scel.1995.0035","article-title":"Cellular regulation of the protein C pathway","volume":"6","author":"Esmon","year":"1995","journal-title":"Semin Cell Biol"},{"key":"10.1378\/chest.121.1.292_bib17","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1016\/S0021-9258(18)83649-3","article-title":"The roles of protein C and thrombomodulin in the regulation of blood coagulation","volume":"264","author":"Esmon","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.121.1.292_bib18","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.4049\/jimmunol.153.8.3664","article-title":"Selective inhibitory effects of the anticoagulant activated protein C on the response of human mononuclear phagocytes to LPS, INF \u03b3, or phorbol ester","volume":"153","author":"Gray","year":"1994","journal-title":"J Immunol"},{"key":"10.1378\/chest.121.1.292_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood.V66.1.59.59","article-title":"Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation","volume":"66","author":"Marlar","year":"1985","journal-title":"Blood"},{"key":"10.1378\/chest.121.1.292_bib20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1055\/s-0038-1651631","article-title":"Activation of protein C and its distribution between its inhibitors, protein C inhibitor, \u03b11-anti-trypsin and \u03b12-macroglobulin, in patients with disseminated intravascular coagulation","volume":"69","author":"Scully","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1378\/chest.121.1.292_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1182\/blood.V73.1.159.159","article-title":"Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture","volume":"73","author":"Moore","year":"1989","journal-title":"Blood"},{"key":"10.1378\/chest.121.1.292_bib22","first-page":"A664","article-title":"The effect of leukocyte elastase on protein C and activated protein C [abstract]","volume":"69","author":"Philapitsch","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1378\/chest.121.1.292_bib23","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","article-title":"Efficacy and safety of recombinant human activated protein C for severe sepsis","volume":"344","author":"Bernard","year":"2001","journal-title":"N Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236921534678X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236921534678X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T08:00:16Z","timestamp":1682496016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001236921534678X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S001236921534678X"],"URL":"https:\/\/doi.org\/10.1378\/chest.121.1.292","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}