{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:42:53Z","timestamp":1774564973747,"version":"3.50.1"},"reference-count":11,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1378\/chest.123.4.1293","type":"journal-article","created":{"date-parts":[[2003,6,13]],"date-time":"2003-06-13T20:09:19Z","timestamp":1055534959000},"page":"1293-1295","source":"Crossref","is-referenced-by-count":97,"title":["Long-term Treatment With Oral Sildenafil in Addition to Continuous IV Epoprostenol in Patients With Pulmonary Arterial Hypertension"],"prefix":"10.1016","volume":"123","author":[{"given":"Leopold","family":"Stiebellehner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ventzislav","family":"Petkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Vonbank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Funk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Ziesche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz-Henning","family":"Block","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.123.4.1293_bib1","series-title":"Executive summary from the World Symposium on Primary Pulmonary Hypertension 1998","year":"1998"},{"key":"10.1378\/chest.123.4.1293_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/hrt.57.3.270","article-title":"Treatment of primary pulmonary hypertension with intravenous epoprostenol (prostacyclin)","volume":"57","author":"Jones","year":"1987","journal-title":"Br Heart J"},{"key":"10.1378\/chest.123.4.1293_bib3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJM199602013340504","article-title":"A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension","volume":"334","author":"Barst","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.123.4.1293_bib4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1056\/NEJM199801293380501","article-title":"Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension","volume":"338","author":"McLaughlin","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.123.4.1293_bib5","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/01.CIR.99.14.1858","article-title":"Long-term prostacyclin for pulmonary hypertension with associated congenital heart defects","volume":"99","author":"Rosenzweig","year":"1999","journal-title":"Circulation"},{"key":"10.1378\/chest.123.4.1293_bib6","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/thorax.56.9.734","article-title":"Aerosolised iloprost improves pulmonary haemodynamics in patients with primary pulmonary hypertension receiving continuous epoprostenol treatment","volume":"5","author":"Petkov","year":"2001","journal-title":"Thorax"},{"key":"10.1378\/chest.123.4.1293_bib7","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.1136\/heart.84.2.e4","article-title":"Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension","volume":"84","author":"Abrams","year":"2000","journal-title":"Heart"},{"key":"10.1378\/chest.123.4.1293_bib8","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJM200011023431814","article-title":"Sildenafil in primary pulmonary hypertension [letter]","volume":"343","author":"Prasad","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.123.4.1293_bib9","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1097\/00002030-200109070-00026","article-title":"Sildenafil in HIV-related pulmonary hypertension","volume":"14","author":"Schumacher","year":"2001","journal-title":"AIDS"},{"key":"10.1378\/chest.123.4.1293_bib10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1183\/09031936.01.17100060","article-title":"Trials of inhaled iloprost and other new vasodilating prostaglandins","volume":"17","author":"Higgenbottam","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.123.4.1293_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.7326\/0003-4819-136-7-200204020-00008","article-title":"Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension","volume":"136","author":"Ghofrani","year":"2002","journal-title":"Ann Intern Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215325496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215325496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T16:24:51Z","timestamp":1553099091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215325496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0012369215325496"],"URL":"https:\/\/doi.org\/10.1378\/chest.123.4.1293","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}