{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:50:08Z","timestamp":1760799008032},"reference-count":14,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1378\/chest.124.1.404","type":"journal-article","created":{"date-parts":[[2003,7,9]],"date-time":"2003-07-09T18:03:36Z","timestamp":1057773816000},"page":"404-406","source":"Crossref","is-referenced-by-count":18,"title":["Emphysema due to \u03b1-Antitrypsin Deficiency"],"prefix":"10.1016","volume":"124","author":[{"given":"Marc","family":"Miravitlles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Vil\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosendo","family":"Jard\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"de la Roza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Rodr\u00edguez-Fr\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.124.1.404_bib1","author":"Jard\u00ed"},{"key":"10.1378\/chest.124.1.404_bib2","first-page":"211","article-title":"Estudio de la frecuencia de los diferentes fenotipos de alfa-1-antitripsina en la poblaci\u00f3n de Barcelona","volume":"107","author":"Vidal","year":"1996","journal-title":"Med Clin (Barc)"},{"key":"10.1378\/chest.124.1.404_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00295662","article-title":"\u03b11-Antitrypsin: evidence of fifth PIM subtype and a new deficiency allele P I* Z Augsburg","volume":"71","author":"Weidinger","year":"1985","journal-title":"Hum Genet"},{"key":"10.1378\/chest.124.1.404_bib4","first-page":"1641","article-title":"Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations","volume":"22","author":"Rodriguez","year":"1995","journal-title":"Hepatology"},{"key":"10.1378\/chest.124.1.404_bib5","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1021\/bi00316a003","article-title":"Complete sequence of the cDNA for human \u03b1-1-antitrypsin and the gene for S variant","volume":"23","author":"Long","year":"1984","journal-title":"Biochemistry"},{"key":"10.1378\/chest.124.1.404_bib6","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1001\/jama.1988.03720190058032","article-title":"Antitrypsin and emphysema: perspective and prospects","volume":"259","author":"Pierce","year":"1988","journal-title":"JAMA"},{"key":"10.1378\/chest.124.1.404_bib7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1378\/chest.95.1.196","article-title":"The \u03b11-antitrypsin gene and its mutations: clinical consequences and strategies for therapy","volume":"95","author":"Crystal","year":"1989","journal-title":"Chest"},{"key":"10.1378\/chest.124.1.404_bib8","first-page":"463","article-title":"Caracterizaci\u00f3n molecular de 2 variantes deficitarias de la alfa-1-antitripsina: PI Mpalermo y PI Plovel","volume":"109","author":"Jard\u00ed","year":"1997","journal-title":"Med Clin (Barc)"},{"key":"10.1378\/chest.124.1.404_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.7326\/0003-4819-136-4-200202190-00006","article-title":"Change in lung function and morbidity from chronic obstructive pulmonary disease in \u03b1-1-antitrypsin MZ heterozygotes: a longitudinal study of the general population","volume":"136","author":"Dahl","year":"2002","journal-title":"Ann Intern Med"},{"issue":"Suppl C","key":"10.1378\/chest.124.1.404_bib10","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1053\/rmed.2000.0854","article-title":"\u03b11-Antitrypsin deficiency: incidence and detection program","author":"Campbell","year":"2000","journal-title":"Respir Med"},{"key":"10.1378\/chest.124.1.404_bib11","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/rccm.2203025","article-title":"Rapid screening for \u03b11-antitrypsin deficiency in patients with chronic obstructive pulmonary disease using dried blood specimens","volume":"166","author":"Rodr\u00edguez","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.124.1.404_bib12","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0954-6111(98)90418-8","article-title":"Usefulness of a national registry of \u03b11-antitrypsin deficiency: the Spanish experience","volume":"92","author":"Miravitlles","year":"1998","journal-title":"Respir Med"},{"key":"10.1378\/chest.124.1.404_bib13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0300-2896(15)30041-7","article-title":"Estado actual del tratamiento sustitutivo en el enfisema cong\u00e9nito por d\u00e9ficit de alfa-1-antitripsina","volume":"35","author":"Miravitlles","year":"1999","journal-title":"Arch Bronconeumol"},{"issue":"suppl 28","key":"10.1378\/chest.124.1.404_bib14","first-page":"382s","article-title":"New formation of the International Registry on Alpha-1-Antitrypsin Deficiency as a joint database of multiple national registries [abstract]","volume":"12","author":"Wencker","year":"1998","journal-title":"Eur Respir J"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215360414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215360414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,17]],"date-time":"2019-03-17T12:54:11Z","timestamp":1552827251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215360414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S0012369215360414"],"URL":"https:\/\/doi.org\/10.1378\/chest.124.1.404","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}