{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:34:06Z","timestamp":1774866846193,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1378\/chest.127.2.550","type":"journal-article","created":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T23:54:00Z","timestamp":1108079640000},"page":"550-557","source":"Crossref","is-referenced-by-count":106,"title":["Cough and Glottic-Stop Reflex Sensitivity in Health and Disease"],"prefix":"10.1016","volume":"127","author":[{"given":"Benjamin","family":"Prudon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surinder S.","family":"Birring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhiraj D.","family":"Vara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian D.","family":"Pavord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.127.2.550_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1183\/09031936.93.05030296","article-title":"Sensitivity of the cough reflex in patients with chronic cough","volume":"5","author":"Choudry","year":"1992","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.127.2.550_bib2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/thorax.55.8.643","article-title":"Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease","volume":"55","author":"Doherty","year":"2000","journal-title":"Thorax"},{"key":"10.1378\/chest.127.2.550_bib3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/gut.46.6.762","article-title":"Cough threshold in reflux oesophagitis: influence of acid and of laryngeal and oesophageal damage","volume":"46","author":"Benini","year":"2000","journal-title":"Gut"},{"key":"10.1378\/chest.127.2.550_bib4","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/bmj.295.6605.1025-a","article-title":"Increased cough reflex associated with angiotensin converting enzyme inhibitor cough","volume":"295","author":"Fuller","year":"1987","journal-title":"BMJ (Clin Res Ed)"},{"key":"10.1378\/chest.127.2.550_bib5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1164\/ajrccm.150.2.8049818","article-title":"Capsaicin cough sensitivity decreases with successful treatment of chronic cough","volume":"150","author":"O'Connell","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.127.2.550_bib6","first-page":"423","article-title":"Resolution of ACE inhibitor cough: changes in subjective cough and responses to inhaled capsaicin, intradermal bradykinin and substance-P","volume":"40","author":"Yeo","year":"1995","journal-title":"Br J Clin Pharmacol"},{"key":"10.1378\/chest.127.2.550_bib7","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1183\/09031936.96.09112220","article-title":"Capsaicin cough receptor sensitivity test in children","volume":"9","author":"Chang","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.127.2.550_bib8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/thx.45.9.694","article-title":"Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs","volume":"45","author":"Nichol","year":"1990","journal-title":"Thorax"},{"key":"10.1378\/chest.127.2.550_bib9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/jappl.1992.73.2.649","article-title":"Contrasting effects of prostaglandins E2 and F2 alpha on sensitivity of the human cough reflex","volume":"73","author":"Stone","year":"1992","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.127.2.550_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/bja\/70.2.131","article-title":"Effect of oral diazepam on the sensitivity of upper airway reflexes","volume":"70","author":"Murphy","year":"1993","journal-title":"Br J Anaesth"},{"key":"10.1378\/chest.127.2.550_bib11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1365-2044.1996.tb07695.x","article-title":"Effects of topical benzocaine and lignocaine on upper airway reflex sensitivity","volume":"51","author":"Raphael","year":"1996","journal-title":"Anaesthesia"},{"key":"10.1378\/chest.127.2.550_bib12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2044.2000.00806.x","article-title":"Upper airway reflex sensitivity following general anaesthesia for day-case surgery","volume":"55","author":"Caranza","year":"2000","journal-title":"Anaesthesia"},{"key":"10.1378\/chest.127.2.550_bib13","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/bja\/73.3.298","article-title":"Sensitivity of upper airway reflexes in cigarette smokers: effect of abstinence","volume":"73","author":"Erskine","year":"1994","journal-title":"Br J Anaesth"},{"key":"10.1378\/chest.127.2.550_bib14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/ajrccm.160.2.9810100","article-title":"Eosinophilic bronchitis is an important cause of chronic cough","volume":"160","author":"Brightling","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.127.2.550_bib15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/thx.40.9.657","article-title":"Diurnal variation and adaptation of the cough response to citric acid in normal subjects","volume":"40","author":"Pounsford","year":"1985","journal-title":"Thorax"},{"key":"10.1378\/chest.127.2.550_bib16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/bja\/70.2.126","article-title":"Measurement of the sensitivity of upper airway reflexes","volume":"70","author":"Langton","year":"1993","journal-title":"Br J Anaesth"},{"key":"10.1378\/chest.127.2.550_bib17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/bja\/82.6.857","article-title":"Upper airway reactivity and upper respiratory tract infection: effect of nebulized lidocaine","volume":"82","author":"Hall","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1378\/chest.127.2.550_bib18","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1378\/chest.113.5.1319","article-title":"The influence of gender on cough reflex sensitivity","volume":"113","author":"Dicpinigaitis","year":"1998","journal-title":"Chest"},{"key":"10.1378\/chest.127.2.550_bib19","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1183\/09031936.96.09081624","article-title":"Female gender as a determinant of cough threshold to inhaled capsaicin","volume":"9","author":"Fujimura","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.127.2.550_bib20","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1164\/rccm.2109061","article-title":"Sex-related differences in cough reflex sensitivity in patients with chronic cough","volume":"166","author":"Kastelik","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.127.2.550_bib21","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/thx.54.1.62","article-title":"Cough threshold in patients with chronic obstructive pulmonary disease","volume":"54","author":"Wong","year":"1999","journal-title":"Thorax"},{"key":"10.1378\/chest.127.2.550_bib22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1378\/chest.121.4.1051","article-title":"A comparison of the validity of different diagnostic tests in adults with asthma","volume":"121","author":"Hunter","year":"2002","journal-title":"Chest"},{"key":"10.1378\/chest.127.2.550_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1094-5539(02)00149-9","article-title":"Short- and long-term reproducibility of capsaicin cough challenge testing","volume":"16","author":"Dicpinigaitis","year":"2003","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1378\/chest.127.2.550_bib24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1183\/09031936.93.05030291","article-title":"Cough receptor sensitivity and bronchial responsiveness in normal and asthmatic subjects","volume":"5","author":"Fujimura","year":"1992","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.127.2.550_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/pupt.2000.0264","article-title":"Effects of inhaled corticosteroids on cough threshold in patients with bronchial asthma","volume":"14","author":"Di Franco","year":"2001","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1378\/chest.127.2.550_bib26","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1034\/j.1399-3003.2000.15d10.x","article-title":"Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis","volume":"15","author":"Brightling","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.127.2.550_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thorax.58.4.339","article-title":"Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"10.1378\/chest.127.2.550_bib28","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1378\/chest.121.4.1123","article-title":"Evaluation of a cough-specific quality-of-life questionnaire","volume":"121","author":"French","year":"2002","journal-title":"Chest"},{"key":"10.1378\/chest.127.2.550_bib29","first-page":"iii48","article-title":"Day time cough counts using the Leicester Cough Monitor (LCM) in patients with chronic cough and healthy controls","volume":"58","author":"Matos","year":"2003","journal-title":"Thorax"},{"key":"10.1378\/chest.127.2.550_bib30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2044.1994.tb03363.x","article-title":"The effect of intravenously administered diazepam, midazolam and flumazenil on the sensitivity of upper airway reflexes","volume":"49","author":"Murphy","year":"1994","journal-title":"Anaesthesia"},{"key":"10.1378\/chest.127.2.550_bib31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/bja\/78.4.352","article-title":"Effect of an upper respiratory tract infection on upper airway reactivity","volume":"78","author":"Nandwani","year":"1997","journal-title":"Br J Anaesth"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215325940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215325940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T04:24:12Z","timestamp":1683001452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215325940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0012369215325940"],"URL":"https:\/\/doi.org\/10.1378\/chest.127.2.550","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}