{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:08:53Z","timestamp":1767236933881,"version":"3.44.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1378\/chest.127.2_suppl.46s","type":"journal-article","created":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T18:58:15Z","timestamp":1108061895000},"page":"46S-52S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"S","title":["Thrombocytopenia in Cardiovascular Patients"],"prefix":"10.1016","volume":"127","author":[{"suffix":"Jr","given":"William H","family":"Matthai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.127.2_suppl.46S_bib1","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJM200106213442502","article-title":"Comparison of two platelet glycoprotein IIb\/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization","volume":"344","author":"Topol","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib2","first-page":"426","article-title":"Incidence of thrombocytopenia following coronary stent placement using abciximab plus clopidogrel or ticlopidine","volume":"50","author":"Dillon","year":"2000","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1378\/chest.127.2_suppl.46S_bib3","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.athoracsur.2003.09.034","article-title":"Heparin-induced thrombocytopenia and cardiac surgery","volume":"76","author":"Warkentin","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.2_suppl.46S_bib4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0735-1097(94)90634-3","article-title":"Clinical importance of thrombocytopenia occurring in the hospital phase after administration of thrombolytic therapy for acute myocardial infarction","volume":"23","author":"Harrington","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.127.2_suppl.46S_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.CIR.103.5.643","article-title":"Prognostic significance of thrombocytopenia during hirudin and heparin therapy in acute coronary syndrome without ST elevation","volume":"103","author":"Eikelboom","year":"2001","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib6","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/01.CIR.99.22.2892","article-title":"Clinical significance of thrombocytopenia during a non-ST elevation acute coronary syndrome","volume":"99","author":"McClure","year":"1999","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0735-1097(98)00252-6","article-title":"Occurrence and clinical significance of thrombocytopenia in a population undergoing high-risk percutaneous coronary revascularization","volume":"32","author":"Berkowitz","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.127.2_suppl.46S_bib8","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/01.CIR.0000066696.57519.AF","article-title":"Anti-platelet factor 4\/heparin antibodies: an independent predictor of 30-day myocardial infarction after acute coronary ischemic syndromes","volume":"107","author":"Williams","year":"2003","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib9","first-page":"43","article-title":"Heparin-induced thrombocytopenia in patients treated with unfractionated heparin: prevalence of thrombosis in a 1 year follow-up","volume":"1","author":"Mattioli","year":"2000","journal-title":"Ital Heart J"},{"key":"10.1378\/chest.127.2_suppl.46S_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/01.CIR.100.6.587","article-title":"Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia","volume":"100","author":"Greinacher","year":"1999","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib11","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/01.CIR.103.14.1838","article-title":"Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia","volume":"103","author":"Lewis","year":"2001","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0735-1097(00)00688-4","article-title":"Occurrence and clinical significance of pseudothrombocytopenia during abciximab therapy","volume":"36","author":"Sane","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.127.2_suppl.46S_bib13","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.281.9.806","article-title":"Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting","volume":"281","author":"Steinhubl","year":"1999","journal-title":"JAMA"},{"key":"10.1378\/chest.127.2_suppl.46S_bib14","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJM200006153422402","article-title":"Thrombotic thrombocytopenic purpura associated with clopidogrel","volume":"342","author":"Bennett","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0140-6736(00)02498-3","article-title":"Clopidogrel and thrombotic thrombocytopenic purpura","volume":"356","author":"Hankey","year":"2000","journal-title":"Lancet"},{"key":"10.1378\/chest.127.2_suppl.46S_bib16","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/S0140-6736(00)03400-0","article-title":"Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomised, placebo-controlled trial","volume":"356","year":"2000","journal-title":"Lancet"},{"key":"10.1378\/chest.127.2_suppl.46S_bib17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199808133390704","article-title":"Inhibition of platelet glycoprotein IIb\/IIIa with eptifibatide in patients with acute coronary syndromes","volume":"339","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib18","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/01.CIR.96.5.1445","article-title":"Effects of platelet glycoprotein IIb\/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty","volume":"96","year":"1997","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib19","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/S0140-6736(96)10172-0","article-title":"Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT-II","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"10.1378\/chest.127.2_suppl.46S_bib20","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/01.CIR.95.4.809","article-title":"Acute profound thrombocytopenia after c7E3 (abciximab) therapy","volume":"95","author":"Berkowitz","year":"1997","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib21","first-page":"177","article-title":"Fatal cerebral hemorrhage and severe thrombocytopenia during abciximab treatment","volume":"49","author":"Vahdat","year":"2000","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1378\/chest.127.2_suppl.46S_bib22","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/hc3301.094533","article-title":"Abciximab readministration: results of the ReoPro readministration study","volume":"104","author":"Tcheng","year":"2001","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0002-9149(99)00768-7","article-title":"Efficacy of abciximab readministration to coronary intervention","volume":"85","author":"Medan","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.127.2_suppl.46S_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/146288401753514515","article-title":"Delayed thrombocytopenia following abciximab therapy","volume":"4","author":"Kaluski","year":"2001","journal-title":"Int J Cardiovasc Intervent"},{"key":"10.1378\/chest.127.2_suppl.46S_bib25","first-page":"486","article-title":"Severe delayed thrombocytopenia associated with abciximab (ReoPro) therapy","volume":"52","author":"Reddy","year":"2001","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1378\/chest.127.2_suppl.46S_bib26","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1182\/blood.V100.6.2071","article-title":"Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb\/IIIa","volume":"100","author":"Bouglie","year":"2002","journal-title":"Blood"},{"key":"10.1378\/chest.127.2_suppl.46S_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1182\/blood-2002-04-1089","article-title":"How I treat heparin-induced thrombocytopenia and thrombosis","volume":"101","author":"Alving","year":"2003","journal-title":"Blood"},{"key":"10.1378\/chest.127.2_suppl.46S_bib28","first-page":"177","article-title":"Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia","volume":"57","author":"Lewis","year":"2002","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1378\/chest.127.2_suppl.46S_bib29","unstructured":"IK Jang, BE Lewis, WH Matthai. Argatroban in conjunction with glycoprotein IIb\/IIIa inhibition in patients undergoing percutaneous coronary intervention: an open-label, nonrandomized pilot study. J Thromb Thrombolysis (in press)"},{"key":"10.1378\/chest.127.2_suppl.46S_bib30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/jama.289.7.853","article-title":"Bivalirudin and provisional glycoprotein IIb\/IIIa blockade compared with heparin and planned glycoprotein IIb\/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial","volume":"289","author":"Lincoff","year":"2003","journal-title":"JAMA"},{"key":"10.1378\/chest.127.2_suppl.46S_bib31","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1161\/01.CIR.0000030314.11999.6A","volume":"106","author":"Braunwald","year":"2002","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1067\/mhj.2000.107554","article-title":"Thrombocytopenia complicating treatment with intravenous glycoprotein IIb\/IIIa receptor inhibitors: a pooled analysis","volume":"140","author":"Dasgupta","year":"2000","journal-title":"Am Heart J"},{"key":"10.1378\/chest.127.2_suppl.46S_bib33","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1056\/NEJM199805213382103","article-title":"A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina","volume":"338","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib34","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1056\/NEJM199805213382102","article-title":"Inhibition of the platelet glycoprotein IIb\/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction","volume":"338","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib35","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1001\/jama.288.15.1851","article-title":"Cost and cost-effectiveness of an early invasive vs conservative strategy of the treatment of unstable angina and non-ST-segment elevation myocardial infarction","volume":"288","author":"Mahoney","year":"2002","journal-title":"JAMA"},{"key":"10.1378\/chest.127.2_suppl.46S_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0140-6736(98)07332-2","article-title":"Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularization procedures in patients with acute myocardial ischaemia without ST elevation: a randomised trial","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"10.1378\/chest.127.2_suppl.46S_bib37","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/01.CIR.92.4.727","article-title":"Hirulog in the treatment of unstable angina: results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) trial","volume":"92","author":"Fuchs","year":"1995","journal-title":"Circulation"},{"key":"10.1378\/chest.127.2_suppl.46S_bib38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1067\/mhj.2002.120405","article-title":"Bivalirudin as a replacement for unfractionated heparin in unstable angina\/non-ST-elevation myocardial infarction: observations from the TIMI 8 trial","volume":"143","author":"Antman","year":"2002","journal-title":"Am Heart J"},{"key":"10.1378\/chest.127.2_suppl.46S_bib39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2796.1999.00452.x","article-title":"Etiology and clinical significance of thrombocytosis: analysis of 732 patients with an elevated platelet count","volume":"245","author":"Greisshammer","year":"1999","journal-title":"J Intern Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0038-1651061","article-title":"Acute and chronic changes in platelet volume and count after cardiopulmonary bypass induced thrombocytopenia in man","volume":"57","author":"Martin","year":"1987","journal-title":"Thromb Haemost"},{"key":"10.1378\/chest.127.2_suppl.46S_bib41","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0003-4975(99)00827-9","article-title":"Blood product use in cardiac revascularization: comparison of on-and off-pump techniques","volume":"68","author":"Nader","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.2_suppl.46S_bib42","first-page":"688a","article-title":"Pre-operative platelet count as baseline is not predictive of heparin-induced thrombocytopenia following cardiac surgery: the HITME (Heparin-Induced Thrombocytopenia Multicenter Evaluation) Trial [abstract]","volume":"100","author":"Gerdisch","year":"2002","journal-title":"Blood"},{"key":"10.1378\/chest.127.2_suppl.46S_bib43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0002-9343(98)00128-4","article-title":"Association of thrombocytopenia with the use of intra-aortic balloon pumps","volume":"105","author":"Vonderheide","year":"1998","journal-title":"Am J Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib44","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1177\/106002809502900901","article-title":"Thrombocytopenia in intensive care patients: a comprehensive analysis of risk factors in 314 patients","volume":"29","author":"Bonfiglio","year":"1995","journal-title":"Ann Pharmacother"},{"key":"10.1378\/chest.127.2_suppl.46S_bib45","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood.V96.5.1703","article-title":"Impact of the patient population on the risk for heparin-induced thrombocytopenia","volume":"96","author":"Warkentin","year":"2000","journal-title":"Blood"},{"key":"10.1378\/chest.127.2_suppl.46S_bib46","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1378\/chest.104.5.1436","article-title":"Complications from heparin-induced thrombocytopenia in patients undergoing cardiopulmonary bypass","volume":"104","author":"Singer","year":"1993","journal-title":"Chest"},{"key":"10.1378\/chest.127.2_suppl.46S_bib47","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0003-4975(92)91437-E","article-title":"Heparin-induced thrombocytopenia in open heart surgical patients: sequelae of late recognition","volume":"53","author":"Walls","year":"1992","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.2_suppl.46S_bib48","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0002-9149(02)02252-X","article-title":"Patency of coronary artery bypass grafts in patients with heparin-induced thrombocytopenia","volume":"89","author":"Liu","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.127.2_suppl.46S_bib49","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM200104263441704","article-title":"Temporal aspects of heparin-induced thrombocytopenia","volume":"344","author":"Warkenitn","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.2_suppl.46S_bib50","unstructured":"Poetzsch R, Madlener K. Management of cardiopulmonary bypass anticoagulation in patients with heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, eds. Heparin-induced thrombocytopenia. 2nd ed. New York, NY: Marcel Dekker, 2001; 429\u2013444"},{"key":"10.1378\/chest.127.2_suppl.46S_bib51","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/S0003-4975(02)04125-5","article-title":"Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery","volume":"74","author":"Vasquez","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.2_suppl.46S_bib52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0003-4975(03)00144-9","article-title":"Bivalirudin use in off-pump-myocardial revascularization in patients with heparin-induced thrombocytopenia","volume":"76","author":"Bott","year":"2003","journal-title":"Ann Thorac Surg"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215308199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215308199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:42:31Z","timestamp":1757918551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215308199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0012369215308199"],"URL":"https:\/\/doi.org\/10.1378\/chest.127.2_suppl.46s","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombocytopenia in Cardiovascular Patients","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.127.2_suppl.46S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}