{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:04:31Z","timestamp":1791255871712,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1378\/chest.127.3.909","type":"journal-article","created":{"date-parts":[[2005,3,12]],"date-time":"2005-03-12T01:58:48Z","timestamp":1110592728000},"page":"909-915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":465,"title":["Phase III Intergroup Study of Talc Poudrage vs Talc Slurry Sclerosis for Malignant Pleural Effusion"],"prefix":"10.1016","volume":"127","author":[{"given":"Carolyn M","family":"Dresler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemi","family":"Olak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"Herndon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Scalzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart B","family":"Fleishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemp H","family":"Kernstine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Demmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Jablons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Kohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B","family":"Haasler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Sugarbaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.127.3.909_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.7326\/0003-4819-120-1-199401010-00010","article-title":"Chemical pleurodesis for malignant pleural effusions","volume":"120","author":"Walker-Renard","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.127.3.909_bib2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0277-5379(86)90009-X","article-title":"A comparison of intracavitary talc and tetracycline for the control of pleural effusions secondary to breast cancer","volume":"22","author":"Fentiman","year":"1986","journal-title":"Eur J Cancer Clin Oncol"},{"key":"10.1378\/chest.127.3.909_bib3","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/bjs.1800761214","article-title":"Comparison of intracavitary bleomycin and talc for control of pleural effusions secondary to carcinoma of the breast","volume":"76","author":"Hamed","year":"1989","journal-title":"Br J Surg"},{"key":"10.1378\/chest.127.3.909_bib4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0022-5223(19)34203-5","article-title":"Comparison of insufflated talc under thoracoscopic guidance with standard tetracycline and bleomycin pleurodesis for control of malignant pleural effusions","volume":"105","author":"Hartman","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.127.3.909_bib5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1378\/chest.112.2.430","article-title":"Prospective randomized trial of talc slurry vs bleomycin in pleurodesis for symptomatic malignant pleural effusions","volume":"112","author":"Zimmer","year":"1997","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib6","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1164\/ajrccm.162.4.2002030","article-title":"Prospective randomized comparison of thoracoscopic talc poudrage under local anesthesia versus bleomycin instillation for pleurodesis in malignant pleural effusions","volume":"162","author":"Diacon","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.127.3.909_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0096-5588(20)32384-9","volume":"4","year":"1935","journal-title":"J Thorac Surg"},{"key":"10.1378\/chest.127.3.909_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0096-5588(20)32217-0","article-title":"The role of experimentally produced intrapleural adhesions in extrapleural pneumonolysis and in the prevention of surgical atelectasis in animals","volume":"10","author":"Hanrahan","year":"1941","journal-title":"J Thorac Surg"},{"key":"10.1378\/chest.127.3.909_bib9","first-page":"26","volume":"66","year":"1958","journal-title":"West J Surg Obstet Gynecol"},{"key":"10.1378\/chest.127.3.909_bib10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0022-5223(19)37535-X","article-title":"Adult respiratory distress syndrome following intrapleural instillation of talc","volume":"85","author":"Rinaldo","year":"1983","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.127.3.909_bib11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0002-9610(99)00075-6","article-title":"Respiratory failure following talc pleurodesis","volume":"177","author":"Rehse","year":"1999","journal-title":"Am J Surg"},{"key":"10.1378\/chest.127.3.909_bib12","first-page":"355a","article-title":"Quality of life (QOL) advantage of sclerosis for malignant pleural effusion (MPE) via talc thoracoscopy over chest tube infusion of talc slurry: a Cancer and Leukemia Group B study [abstract]","volume":"21","author":"Fleishman","year":"2002","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1378\/chest.127.3.909_bib13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1378\/chest.127.3.909_bib14","unstructured":"Common toxicity criteria, version 2.0. Bethesda, MD: National Cancer Institute, 1999"},{"key":"10.1378\/chest.127.3.909_bib15","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1378\/chest.106.4.1215","article-title":"Talc pleurodesis for the treatment of pneumothorax and pleural effusion","volume":"106","author":"Kennedy","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib16","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0003-4975(96)00808-9","article-title":"Thoracoscopic talc insufflation versus talc slurry for symptomatic malignant pleural effusion","volume":"62","author":"Yim","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.3.909_bib17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0003-4975(96)00488-2","article-title":"Talc pleurodesis: talc slurry versus thoracoscopic talc insufflation in a porcine model","volume":"62","author":"Cohen","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.3.909_bib18","doi-asserted-by":"crossref","unstructured":"Rodriguez Panadero F. Lung cancer and ipsilateral pleural effusion. Ann Oncol 1995; 6(suppl):S25\u2013S27","DOI":"10.1093\/annonc\/6.suppl_3.S25"},{"key":"10.1378\/chest.127.3.909_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1148\/radiology.210.1.r99dc04277","article-title":"Malignant pleural effusions: treatment with small-bore-catheter thoracostomy and talc pleurodesis","volume":"210","author":"Marom","year":"1999","journal-title":"Radiology"},{"key":"10.1378\/chest.127.3.909_bib20","first-page":"156","article-title":"Talc pleurodesis in recurrent pleural effusions","volume":"383","author":"Jacobi","year":"1998","journal-title":"Langenbecks Arch Surg"},{"key":"10.1378\/chest.127.3.909_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0003-4975(10)63944-6","article-title":"Treatment of malignant pleural effusion: a method using tube thoracostomy and talc","volume":"22","author":"Adler","year":"1976","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.3.909_bib22","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0003-4975(01)02586-3","article-title":"Effective treatment of malignant pleural effusion by minimal invasive thoracic surgery: thoracoscopic talc pleurodesis and pleuroperitoneal shunts in 101 patients","volume":"71","author":"Schulze","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.127.3.909_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/thx.24.1.69","article-title":"Treatment of recurrent malignant pleural effusion by iodized talc pleurodesis","volume":"24","author":"Jones","year":"1969","journal-title":"Thorax"},{"key":"10.1378\/chest.127.3.909_bib24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1378\/chest.106.2.342","article-title":"Pleurodesis using talc slurry","volume":"106","author":"Kennedy","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1378\/chest.117.1.73","article-title":"Predicting survival in patients with recurrent symptomatic malignant pleural effusions: an assessment of the prognostic values of physiologic, morphologic, and quality of life measures of extent of disease","volume":"117","author":"Burrows","year":"2000","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib26","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.110.6.1387","article-title":"Thoracoscopic talc poudrage pleurodesis for malignant effusions: a review of 360 cases","volume":"110","author":"Viallat","year":"1996","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib27","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0022-5223(19)33712-2","article-title":"Talc pleurodesis: experience with 360 patients","volume":"106","author":"Weissberg","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.127.3.909_bib28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1378\/chest.86.5.795","article-title":"Acute pneumonitis with bilateral pleural effusion after talc pleurodesis","volume":"86","author":"Bouchama","year":"1984","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1378\/chest.119.3.801","article-title":"Thoracoscopy talc poudrage: a 15-year experience","volume":"119","author":"Decampos","year":"2001","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib30","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1378\/chest.122.3.1018","article-title":"Influence of particle size on extrapleural talc dissemination after talc slurry pleurodesis","volume":"122","author":"Ferrer","year":"2002","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib31","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1378\/chest.119.6.1901","article-title":"Talc preparations used for pleurodesis vary markedly from one preparation to another","volume":"119","author":"Ferrer","year":"2001","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1378\/chest.115.1.190","article-title":"Systemic distribution of talc after intrapleural administration in rats","volume":"115","author":"Werebe","year":"1999","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib33","first-page":"233","article-title":"Evaluation of respiratory effects in miners and millers exposed to talc free of asbestos and silica","volume":"39","author":"Wegman","year":"1982","journal-title":"Br J Ind Med"},{"key":"10.1378\/chest.127.3.909_bib34","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1378\/chest.113.3.739","article-title":"Video-assisted talc pleurodesis for malignant pleural effusions utilizing local anesthesia and IV sedation","volume":"113","author":"Danby","year":"1998","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib35","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1378\/chest.104.5.1482","article-title":"Rodriguez-Panadero, F Survival and talc pleurodesis in metastatic pleural carcinoma, revisited. Report of 125 cases","volume":"104","author":"Sanchez-Armengol","year":"1993","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib36","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1164\/ajrccm\/151.3_Pt_1.785","article-title":"Failure of talc pleurodesis is associated with increased pleural fibrinolysis","volume":"151","author":"Rodriguez-Panadero","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.127.3.909_bib37","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1378\/chest.113.4.1007","article-title":"Thoracoscopic talc poudrage in malignant pleural effusions: effective pleurodesis despite low pleural pH","volume":"113","author":"Aelony","year":"1998","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1378\/chest.117.1.87","article-title":"Pleural fluid pH as a predictor of pleurodesis failure","volume":"117","author":"Heffner","year":"2000","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.909_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1378\/chest.117.1.79","article-title":"Pleural fluid pH as a predictor of survival for patients with malignant pleural effusions","volume":"117","author":"Heffner","year":"2000","journal-title":"Chest"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215311028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215311028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:42:27Z","timestamp":1757918547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215311028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0012369215311028"],"URL":"https:\/\/doi.org\/10.1378\/chest.127.3.909","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phase III Intergroup Study of Talc Poudrage vs Talc Slurry Sclerosis for Malignant Pleural Effusion","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.127.3.909","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}