{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:05:13Z","timestamp":1791281113222,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1378\/chest.127.3.942","type":"journal-article","created":{"date-parts":[[2005,3,12]],"date-time":"2005-03-12T01:58:48Z","timestamp":1110592728000},"page":"942-951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":120,"title":["Incidence and Impact of Organ Dysfunctions Associated With Sepsis"],"prefix":"10.1016","volume":"127","author":[{"given":"Bertrand","family":"Guidet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Aegerter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Gauzit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Meshaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dreyfuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.127.3.942_bib1","doi-asserted-by":"crossref","unstructured":"Members of the American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. 1992; 20:864\u2013874","DOI":"10.1097\/00003246-199206000-00025"},{"key":"10.1378\/chest.127.3.942_bib2","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1097\/00003246-200107001-00035","article-title":"Epidemiology of sepsis: an update","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib3","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.3.942_bib4","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1097\/01.CCM.0000085141.75513.2B","article-title":"Epidemiology of severe sepsis occurring in the first 24 h in intensive care units in England, Wales and Northern Ireland","volume":"31","author":"Padkin","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00134-003-2121-4","article-title":"The Episepsis Study Group. Episepsis: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units","volume":"30","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00134-004-2157-0","article-title":"Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units","volume":"30","author":"Finfer","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib7","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","article-title":"Efficacy and safety of recombinant human activated protein C for severe sepsis","volume":"344","author":"Bernard","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.3.942_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1164\/rccm.2201087","article-title":"Epidemiology of septic shock in Paris and suburban 1993\u20132000: the CUB-R\u00e8a network","volume":"168","author":"Annane","year":"2003","journal-title":"Am Rev Respir Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib10","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMsb020574","article-title":"Risks and benefits of activated protein C treatment for severe sepsis","volume":"347","author":"Warren","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.3.942_bib11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archinte.1962.03620240029006","article-title":"Gram-negative bacteriemia: I. Etiology and ecology","volume":"110","author":"McCabe","year":"1962","journal-title":"Arch Intern Med"},{"key":"10.1378\/chest.127.3.942_bib12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical morbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J Clin Epidemiol"},{"key":"10.1378\/chest.127.3.942_bib13","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new simplified acute physiology score based on a European-North American multicenter study","volume":"270","author":"LeGall","year":"1993","journal-title":"JAMA"},{"key":"10.1378\/chest.127.3.942_bib14","first-page":"226","article-title":"Mise en \u0153uvre et \u00e8valuation d'une base de donn\u00e8es commune aux services de r\u00e8animation d'Ile-de-France","volume":"46","author":"Aegerter","year":"1998","journal-title":"Rev Epidemiol Sante Publique"},{"key":"10.1378\/chest.127.3.942_bib15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s001340000760","article-title":"A cost-effectiveness approach of stays in intensive care units","volume":"27","author":"Sznajder","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/jcrc.2002.35815","article-title":"for CUB-R\u00e8a. Systemic candidiasis in intensive care units: a multicenter matched-cohort study","volume":"17","author":"Leleu","year":"2002","journal-title":"J Crit Care"},{"key":"10.1378\/chest.127.3.942_bib17","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib18","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/00003246-200104000-00039","article-title":"New strategies for clinical trials in patients with sepsis and septic shock","volume":"29","author":"Cohen","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib19","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1007\/BF01740762","article-title":"The Italian SEPSIS study: preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock","volume":"21","author":"Salvo","year":"1995","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/00003246-199702000-00029","article-title":"Dear SIRS, I'm sorry to say that I don't like you","volume":"25","author":"Vincent","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00134-001-1143-z","article-title":"Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study","volume":"28","author":"Alberti","year":"2002","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib22","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1378\/chest.101.6.1656","article-title":"Evaluation of definitions for sepsis","volume":"101","author":"Knaus","year":"1992","journal-title":"Chest"},{"key":"10.1378\/chest.127.3.942_bib23","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1001\/jama.1995.03530120060042","article-title":"Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: a multicenter prospective study in intensive care units","volume":"274","author":"Brun-Buisson","year":"1995","journal-title":"JAMA"},{"key":"10.1378\/chest.127.3.942_bib24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1164\/ajrccm.154.3.8810595","article-title":"Bacteremia and severe sepsis in adults: a multicenter prospective survey in ICUs and wards of 24 hospitals","volume":"154","author":"Brun-Buisson","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib25","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1001\/jama.1997.03550030074038","article-title":"Epidemiology of sepsis syndrome in 8 academic medical centers","volume":"278","author":"Sands","year":"1997","journal-title":"JAMA"},{"key":"10.1378\/chest.127.3.942_bib26","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1097\/00003246-199909000-00010","article-title":"The patient-related costs of care for sepsis patients in a United Kingdom adult general intensive care unit","volume":"27","author":"Edbrooke","year":"1999","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s001340050041","article-title":"Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome","volume":"26","author":"Wichmann","year":"2000","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1001\/jama.1995.03520260039030","article-title":"The natural history of the systemic inflammatory response syndrome (SIRS): a prospective study","volume":"273","author":"Rangel-Frausto","year":"1995","journal-title":"JAMA"},{"key":"10.1378\/chest.127.3.942_bib29","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1007\/s00134-002-1429-9","article-title":"Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use","volume":"28","author":"Moerer","year":"2002","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib30","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1097\/00003246-199812000-00045","article-title":"Has the mortality of septic shock changed with time?","volume":"26","author":"Friedman","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.127.3.942_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0891-5520(05)70076-3","article-title":"The epidemiology of bacterial sepsis","volume":"13","author":"Rangel-Frausto","year":"1999","journal-title":"Infect Dis Clin North Am"},{"key":"10.1378\/chest.127.3.942_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1056\/NEJM199901213400307","article-title":"Treating patients with severe sepsis","volume":"340","author":"Wheeler","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.127.3.942_bib33","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1001\/jama.1995.03520320054041","article-title":"Customized probability models for early severe sepsis in adult intensive care patients","volume":"273","author":"Le Gall","year":"1995","journal-title":"JAMA"},{"key":"10.1378\/chest.127.3.942_bib34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/jama.1995.03520280052039","article-title":"Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983\u20131993","volume":"273","author":"Milberg","year":"1995","journal-title":"JAMA"},{"key":"10.1378\/chest.127.3.942_bib35","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1007\/s001340100961","article-title":"Accuracy of composite score using daily SAPS II and LOD scores for predicting hospital mortality in ICU patients hospitalized for more than 72 h","volume":"27","author":"Timsit","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib36","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s001340051055","article-title":"Septic shock without documented infection: an uncommon entity with a high mortality","volume":"25","author":"Reyes","year":"1999","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.127.3.942_bib37","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00134-003-1731-1","article-title":"Drotrecogin alpha (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial","volume":"29","author":"Dhainaut","year":"2003","journal-title":"Intensive Care Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215311077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215311077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:44:03Z","timestamp":1757918643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215311077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0012369215311077"],"URL":"https:\/\/doi.org\/10.1378\/chest.127.3.942","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence and Impact of Organ Dysfunctions Associated With Sepsis","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.127.3.942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}