{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:01:18Z","timestamp":1790499678585,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1378\/chest.129.1.118","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T21:58:27Z","timestamp":1137707907000},"page":"118-123","source":"Crossref","is-referenced-by-count":114,"title":["Mucus Properties In Children With Primary Ciliary Dyskinesia"],"prefix":"10.1016","volume":"129","author":[{"given":"Andrew","family":"Bush","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus O.","family":"Henke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce K.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.129.1.118_bib1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1183\/09031936.98.12040982","article-title":"Primary ciliary dyskinesia: diagnosis and standards of care","volume":"12","author":"Bush","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.129.1.118_bib2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1651-2227.2002.tb03299.x","article-title":"Primary ciliary dyskinesia (PCD) in children: age at diagnosis and symptom history","volume":"91","author":"Coren","year":"2002","journal-title":"Acta Paediatrica"},{"key":"10.1378\/chest.129.1.118_bib3","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1183\/09031936.97.10102376","article-title":"Longitudinal study of lung function in a cohort of primary ciliary dyskinesia","volume":"10","author":"Ellerman","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.129.1.118_bib4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1164\/rccm.200303-365OC","article-title":"Primary ciliary dyskinesia: diagnostic and phenotypic features","volume":"169","author":"Noone","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.1.118_bib5","doi-asserted-by":"crossref","first-page":"L588","DOI":"10.1152\/ajplung.00302.2003","article-title":"Mucociliary transport determined byin vivomicrodialysis in the airways of normal and CF mice","volume":"286","author":"Grubb","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1378\/chest.129.1.118_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1183\/09031936.04.00097503","article-title":"Normal mucociliary clearance in CF children: evidence against a CFTR-related defect","volume":"24","author":"McShane","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.129.1.118_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1183\/09031936.05.00120103","article-title":"Long-term clearance from small airways in patients with cystic fibrosis","volume":"25","author":"Lindstrom","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.129.1.118_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1165\/ajrcmb.23.2.4214","article-title":"Inflammation and infection in naive human cystic fibrosis airway grafts","volume":"23","author":"Tirouvanziam","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1378\/chest.129.1.118_bib9","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1183\/09031936.97.10102376","article-title":"Longitudinal study of lung function in a cohort of primary ciliary dyskinesia","volume":"10","author":"Ellerman","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.129.1.118_bib10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1164\/rccm.200303-365OC","article-title":"Primary ciliary dyskinesia: diagnostic and phenotypic features","volume":"169","author":"Noone","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.1.118_bib11","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/thorax.57.7.586","article-title":"Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance","volume":"57","author":"Narang","year":"2002","journal-title":"Thorax"},{"key":"10.1378\/chest.129.1.118_bib12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-3476(98)70344-0","article-title":"The diagnosis of cystic fibrosis: a consensus statement","volume":"132","author":"Rosenstein","year":"1998","journal-title":"J Pediatr"},{"key":"10.1378\/chest.129.1.118_bib13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry, 1994 update","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.1.118_bib14","first-page":"283","article-title":"Mucus rheology: relationship with transport","author":"King","year":"1994"},{"key":"10.1378\/chest.129.1.118_bib15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3233\/BIR-1983-20214","article-title":"Spinability of bronchial mucus: relationship with viscoelasticity and mucous transport properties","volume":"20","author":"Puchelle","year":"1983","journal-title":"Biorheology"},{"key":"10.1378\/chest.129.1.118_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1152\/jappl.1990.69.2.424","article-title":"Mucus-depleted frog palate as a model for the study of mucociliary clearance","volume":"69","author":"Rubin","year":"1990","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.129.1.118_bib17","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3233\/BIR-1989-26602","article-title":"Mucus transport in a miniaturized simulated cough machine: effect of constriction and serous layer simulant","volume":"26","author":"Agarwal","year":"1989","journal-title":"Biorheology"},{"key":"10.1378\/chest.129.1.118_bib18","first-page":"317","article-title":"Surface properties of respiratory secretions: relationship to mucus transport","author":"Rubin","year":"1998"},{"key":"10.1378\/chest.129.1.118_bib19","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1152\/jappl.1996.81.6.2690","article-title":"Ring distraction technique for measuring surface tension of sputum: relationship to sputum clearability","volume":"81","author":"Albers","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.129.1.118_bib20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ppul.1101","article-title":"Sputum processing for evaluation of inflammatory mediators","volume":"32","author":"Kim","year":"2001","journal-title":"Pediatr Pulmonol"},{"key":"10.1378\/chest.129.1.118_bib21","first-page":"465","article-title":"Chemical markers of mucous and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases","volume":"117","author":"Lopez-Vidriero","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.129.1.118_bib22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1203\/00006450-198102000-00007","article-title":"Is cystic fibrosis mucus abnormal?","volume":"15","author":"King","year":"1981","journal-title":"Pediatr Res"},{"key":"10.1378\/chest.129.1.118_bib23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0006-355X(95)92361-D","article-title":"Rheologic properties of airway secretions in cystic fibrosis, chronic bronchitis, and fatal asthma","volume":"32","author":"Tomkiewicz","year":"1995","journal-title":"Biorheology"},{"key":"10.1378\/chest.129.1.118_bib24","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0007-0971(70)80015-8","article-title":"Sputum viscosity in cystic fibrosis of the pancreas and other pulmonary diseases","volume":"64","author":"Feather","year":"1970","journal-title":"Br J Dis Chest"},{"key":"10.1378\/chest.129.1.118_bib25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ppul.1950130103","article-title":"A superficial view of mucus and the cystic fibrosis defect","volume":"13","author":"Rubin","year":"1992","journal-title":"Pediatr Pulmonol"},{"key":"10.1378\/chest.129.1.118_bib26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1165\/rcmb.2003-0345OC","article-title":"MUC5AC and MUC5B mucins are decreased in cystic fibrosis airway secretions","volume":"31","author":"Henke","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1378\/chest.129.1.118_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ppul.1950130107","article-title":"Phospholipid composition and surface-active properties of tracheobronchial secretions from patients with cystic fibrosis and chronic obstructive pulmonary diseases","volume":"13","author":"Girod","year":"1992","journal-title":"Pediatr Pulmonol"},{"key":"10.1378\/chest.129.1.118_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1164\/ajrccm.156.1.9606123","article-title":"Revisited physicochemical and transport properties of respiratory mucus in genotyped cystic fibrosis patients","volume":"156","author":"Deneuville","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.1.118_bib29","first-page":"254","article-title":"Mucociliary transportin vivoandin vitro: relations to sputum properties in chronic bronchitis","volume":"61","author":"Puchelle","year":"1980","journal-title":"Eur J Respir Dis"},{"key":"10.1378\/chest.129.1.118_bib30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0006-355X(95)92361-D","article-title":"Rheologic properties of airway secretions in cystic fibrosis, chronic bronchitis, and fatal asthma","volume":"32","author":"Tomkiewicz","year":"1995","journal-title":"Biorheology"},{"key":"10.1378\/chest.129.1.118_bib31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3233\/BIR-1983-20214","article-title":"Spinability of bronchial mucus: relationship with viscoelasticity and mucous transport properties","volume":"20","author":"Puchelle","year":"1983","journal-title":"Biorheology"},{"key":"10.1378\/chest.129.1.118_bib32","first-page":"199","article-title":"Studies on pulmonary secretions: 1. The overall composition of pulmonary secretions from patients with cystic fibrosis, bronchiectasis and laryngectomy","volume":"88","author":"Matthews","year":"1963","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.129.1.118_bib33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1089\/jam.2000.13.263","article-title":"Respiratory-related quality of life: relation to pulmonary function, functional exercise capacity, and sputum biophysical properties","volume":"13","author":"Piquette","year":"2000","journal-title":"J Aerosol Med"},{"key":"10.1378\/chest.129.1.118_bib34","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1164\/ajrccm.162.5.9908107","article-title":"DNA and actin bind and inhibit interleukin-8 function in cystic fibrosis sputa:in vitroeffect of mucolytics","volume":"162","author":"Perks","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.1.118_bib35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/thx.50.4.360","article-title":"Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid","volume":"50","author":"Riise","year":"1995","journal-title":"Thorax"},{"key":"10.1378\/chest.129.1.118_bib36","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1164\/ajrccm.155.3.9116985","article-title":"Cytokine concentrations in sputum from patients with cystic fibrosis and their relation to eosinophil activity","volume":"155","author":"Koller","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.1.118_bib37","first-page":"L413","article-title":"Interleuken-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases","volume":"264","author":"Richman-Eisenstat","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1378\/chest.129.1.118_bib38","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0091-6749(93)90078-T","article-title":"Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease","volume":"92","author":"Lacoste","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.129.1.118_bib39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.112.2.505","article-title":"Airway inflammation in COPD assessed by sputum levels of interleukin-B","volume":"112","author":"Yamamoto","year":"1997","journal-title":"Chest"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215315300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215315300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T16:17:46Z","timestamp":1555345066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215315300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0012369215315300"],"URL":"https:\/\/doi.org\/10.1378\/chest.129.1.118","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}