{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:44:42Z","timestamp":1782801882531,"version":"3.54.5"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1378\/chest.129.2.438","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T19:38:13Z","timestamp":1139945893000},"page":"438-445","source":"Crossref","is-referenced-by-count":9,"title":["The Oxyhemoglobin Dissociation Curve in Liver Cirrhosis"],"prefix":"10.1016","volume":"129","author":[{"given":"Thierry","family":"Clerbaux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Detry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Geubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Veriter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Liistro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Horsmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Frans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.129.2.438_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0021-9258(18)74182-3","article-title":"The salts effects on the hemoglobin oxygen equilibrium","volume":"123","author":"Sidwell","year":"1938","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.129.2.438_bib2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0021-9258(18)64374-1","article-title":"Studies on the relations between molecular and functional properties of hemoglobin: II. The effects of salts on the oxygen equilibrium of human hemoglobin","volume":"236","author":"Rossi-Fanelli","year":"1961","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.129.2.438_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0021-9258(18)64374-1","article-title":"Studies on the relations between molecular and functional properties of hemoglobin: III. The influence of salts on the Bohr effect in human hemoglobin","volume":"236","author":"Antonini","year":"1961","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.129.2.438_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1423-0410.1971.tb01806.x","article-title":"The function of human hemoglobin, salts effects","volume":"20","author":"Dawson","year":"1971","journal-title":"Vox Sanguinis"},{"key":"10.1378\/chest.129.2.438_bib5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1152\/jappl.1977.43.4.632","article-title":"Hemoglobin oxygen affinity regulation: DPG monovalent anions and hemoglobin concentration","volume":"43","author":"Laver","year":"1977","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.129.2.438_bib6","first-page":"121","article-title":"The effects of anions and cations on the oxygen equilibrium of human hemoglobin","author":"Antonini","year":"1979","journal-title":"Oxygen affinity of hemoglobin and red cell base status"},{"key":"10.1378\/chest.129.2.438_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0022-2836(81)90097-8","article-title":"Interaction of hemoglobin with salts: effects on the functional properties of human hemoglobin","volume":"152","author":"Amiconi","year":"1981","journal-title":"J Mol Biol"},{"key":"10.1378\/chest.129.2.438_bib8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/00000441-195911000-00002","article-title":"Cyanosis, clubbing and arterial oxygen unsaturation associated with Laennec's cirrhosis","volume":"238","author":"Rodman","year":"1959","journal-title":"Am J Med Sci"},{"key":"10.1378\/chest.129.2.438_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9343(60)90187-X","article-title":"Hyperventilation and arterial hypoxemia in cirrhosis of the liver","volume":"28","author":"Heinemann","year":"1960","journal-title":"Am J Med"},{"key":"10.1378\/chest.129.2.438_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI100928","article-title":"Respiratory properties of the arterial blood in normal man and in patients with disease of the liver: position of the oxygen dissociation curve","volume":"17","author":"Keys","year":"1938","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.129.2.438_bib11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1152\/jappl.1965.20.2.316","article-title":"Oxyhemoglobin dissociation curve in liver disease","volume":"31","author":"Caldwell","year":"1965","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.129.2.438_bib12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0006-291X(67)90228-8","article-title":"The effect of organic phosphates from human erythrocyte on the allosteric properties of human hemoglobin","volume":"26","author":"Benesch","year":"1967","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1378\/chest.129.2.438_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0003-9861(67)90013-6","article-title":"Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes","volume":"121","author":"Chanutin","year":"1967","journal-title":"Arch Biochem Biophys"},{"key":"10.1378\/chest.129.2.438_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0003-9861(69)90119-2","article-title":"The interaction of organic and inorganic phosphates with hemoglobin","volume":"131","author":"Chanutin","year":"1969","journal-title":"Arch Biochem Biophys"},{"key":"10.1378\/chest.129.2.438_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.me.25.020174.000333","article-title":"2,3 DPG and erythrocytes oxygen affinity","volume":"25","author":"Brewer","year":"1974","journal-title":"Ann Rev Med"},{"key":"10.1378\/chest.129.2.438_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/00365517309082436","article-title":"Oxygen affinity of hemoglobin and red cell 2,3 diphosphoglycerate in hepatic cirrhosis","volume":"31","author":"Astrup","year":"1973","journal-title":"Scand J Clin Invest"},{"key":"10.1378\/chest.129.2.438_bib17","first-page":"463","article-title":"The oxygen dissociation curve of hemoglobin in hepatic cirrhosis","volume":"64","author":"Stabilini","year":"1973","journal-title":"Minerva Med"},{"key":"10.1378\/chest.129.2.438_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0002-9343(74)90129-6","article-title":"The oxyhemoglobin dissociation curve in health and disease","volume":"57","author":"Thomas","year":"1974","journal-title":"Am J Med"},{"key":"10.1378\/chest.129.2.438_bib19","first-page":"222","article-title":"Adaptation to hypoxia in liver cirrhosis: the role of 2,3 DPG","volume":"15","author":"Corti","year":"1979","journal-title":"Quad Sclavo Diagn"},{"key":"10.1378\/chest.129.2.438_bib20","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/00365518209168139","article-title":"Relationship of red-cell 2,3-diphosphoglycerate with anemia, hypoxemia and acid-base status in patients with cirrhosis of the liver","volume":"42","author":"Espinos","year":"1982","journal-title":"Scand J Lab Invest"},{"key":"10.1378\/chest.129.2.438_bib21","first-page":"107","article-title":"2,3-Diphosphoglycerate and tissue oxygenation in the cirrhotics","volume":"61","author":"Vendemiale","year":"1985","journal-title":"Boll Soc Ital Biol Sper"},{"key":"10.1378\/chest.129.2.438_bib22","first-page":"1283","article-title":"Erythrocyte 2,3-diphosphoglycerate in liver disease","volume":"82","author":"Nakano","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"10.1378\/chest.129.2.438_bib23","first-page":"1085","article-title":"Gas exchange and pulmonary vascular reactivity in patients with liver cirrhosis","volume":"135","author":"Rodriguez-Roisin","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.129.2.438_bib24","first-page":"345","article-title":"The advantages of a dynamic method used for graphing the oxyhemoglobin dissociation curve of whole blood at constant temperature, pH and pCO2","volume":"66","author":"Clerbaux","year":"1975","journal-title":"Acta Tuberc Belg"},{"key":"10.1378\/chest.129.2.438_bib25","first-page":"8","article-title":"Effect of inorganic ions on the oxyhemoglobin dissociation curve of severely ill patients","volume":"46","author":"Frans","year":"1998","journal-title":"Pathol Biol"},{"key":"10.1378\/chest.129.2.438_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF00273559","article-title":"Effect of inorganic phosphates on oxyhemoglobin affinity, diphosphoglycerate and blood gases during recovery from diabetic ketoacidosis","volume":"15","author":"Clerbaux","year":"1989","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.129.2.438_bib27","first-page":"259","article-title":"Plasmatic ions influence the oxyhemoglobin dissociation curve of patients with chronic obstructive lung disease","volume":"44","author":"Clerbaux","year":"1996","journal-title":"Pathol Biol"},{"key":"10.1378\/chest.129.2.438_bib28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF01709836","article-title":"Reestimation of the effects of inorganic phosphates on the equilibrium between oxygen and hemoglobin","volume":"18","author":"Clerbaux","year":"1992","journal-title":"Intensive Care Med"},{"key":"10.1378\/chest.129.2.438_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0021-9258(19)70661-9","article-title":"Oxygen-linked binding sites of inorganic anions to hemoglobin","volume":"255","author":"Nigen","year":"1980","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.129.2.438_bib30","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1056\/NEJM198112033052302","article-title":"Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis","volume":"305","author":"Lebrec","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.129.2.438_bib31","first-page":"1","article-title":"A dynamic method for continuous recording of the whole blood oxyhemoglobin dissociation curve at constant temperature, pH and PCO2","volume":"30","author":"Clerbaux","year":"1973","journal-title":"Med Lab Technol"},{"key":"10.1378\/chest.129.2.438_bib32","first-page":"245","author":"Clerbaux","year":"1992","journal-title":"La courbe de dissociation de l'oxyh\u00e9moglobine: aspects m\u00e9thodologiques, physiologiques et physiopathologiques. Thesis"},{"key":"10.1378\/chest.129.2.438_bib33","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1152\/jappl.1965.20.5.1098","article-title":"Continuous duty tonometer system","volume":"20","author":"Farhi","year":"1965","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.129.2.438_bib34","first-page":"342","article-title":"Oxygen content determination using a new analyzer: the Lex-O2-Con","volume":"82","author":"Clerbaux","year":"1973","journal-title":"J Lab Clin Med"},{"key":"10.1378\/chest.129.2.438_bib35","first-page":"503","author":"Snedecor","year":"1989"},{"key":"10.1378\/chest.129.2.438_bib36","first-page":"1170","author":"West","year":"1989"},{"key":"10.1378\/chest.129.2.438_bib37","first-page":"1105","article-title":"Enzymes controlling 2,3-diphosphoglycerate in human erythrocytes","volume":"29","author":"Rose","year":"1971","journal-title":"Fed Proc"},{"key":"10.1378\/chest.129.2.438_bib38","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1172\/JCI106540","article-title":"Regulatory mechanisms of hemoglobin oxygen affinity in acidosis and alkalosis","volume":"50","author":"Bellingham","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.129.2.438_bib39","doi-asserted-by":"crossref","first-page":"562","DOI":"10.7326\/0003-4819-74-4-562","article-title":"Reduced red cell glycolysis, 2,3-diphosphogIvcerate and adenosine triphosphate concentration and increased hemoglobin-oxygen affinity caused by hypophosphatemia","volume":"74","author":"Lichtman","year":"1971","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.129.2.438_bib40","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1056\/NEJM197302222880803","article-title":"The anemia in childhood: evidence for a physiologic response to hyperphosphatemia","volume":"288","author":"Card","year":"1973","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.129.2.438_bib41","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1172\/JCI105948","article-title":"Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels","volume":"47","author":"Lenfant","year":"1968","journal-title":"J Clin lnvest"},{"key":"10.1378\/chest.129.2.438_bib42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/01.RES.25.1.47","article-title":"Decreased affinity of blood for oxygen in patients with low-output heart failure","volume":"25","author":"Metcalfe","year":"1969","journal-title":"Circ Res"},{"key":"10.1378\/chest.129.2.438_bib43","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI102342","article-title":"The position of the oxygen dissociation curve of the blood in cyanotic congenital heart disease","volume":"29","author":"Morse","year":"1950","journal-title":"Clin Invest"},{"key":"10.1378\/chest.129.2.438_bib44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1056\/NEJM197101142840205","article-title":"Red cell 2,3 DPG creatinine levels in patients with red cell mass deficits or with cardiopulmonary insufficiency","volume":"284","author":"Valeri","year":"1969","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.129.2.438_bib45","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1056\/NEJM196905222802108","article-title":"Red cell 2,3-diphosphoglycerate levels in subjects with chronic hypoxemia","volume":"280","author":"Oski","year":"1969","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.129.2.438_bib46","first-page":"683","article-title":"Blood 2,3-diphosphoglycerate level (DPG) in chronic obstructive airway disease [abstract]","volume":"19","author":"Manfredi","year":"1971","journal-title":"Clin Res"},{"key":"10.1378\/chest.129.2.438_bib47","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1164\/ajrccm\/143.3.486","article-title":"Decreased oxyhemoglobin affinity in patients with sleep apnea syndrome","volume":"143","author":"Maillard","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.129.2.438_bib48","first-page":"269","article-title":"Right shift of the oxyhemoglobin dissociation curve in acute respiratory distress syndrome","volume":"45","author":"Clerbaux","year":"1997","journal-title":"Path Biol"},{"key":"10.1378\/chest.129.2.438_bib49","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1172\/JCI106351","article-title":"The effects of cardiac disease on hemoglobin-oxygen binding","volume":"48","author":"Woodson","year":"1970","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.129.2.438_bib50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000458860","article-title":"Undifferentiated patterns of key carbohydrate-metabolizing enzymes in injured livers: II. Human viral hepatitis and cirrhosis of the liver","volume":"21","author":"Taketa","year":"1976","journal-title":"Enzyme"},{"key":"10.1378\/chest.129.2.438_bib51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0168-8278(85)80055-6","article-title":"Carbohydrate intolerance associated with reduced hepatic glucose phosphorylating and releasing enzyme activities and peripheral insulin resistance in alcoholics with liver cirrhosis","volume":"1","author":"Sotaniemi","year":"1985","journal-title":"J Hepatol"},{"key":"10.1378\/chest.129.2.438_bib52","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0304-4165(97)00092-5","article-title":"Hexokinase isoenzymes in normal and cirrhotic liver suppression of glucokinase in cirrhosis","volume":"179","author":"Lowes","year":"1998","journal-title":"Biochem Biophys Acta"},{"key":"10.1378\/chest.129.2.438_bib53","first-page":"1284","article-title":"Oxygen factors in hyperthyroidism","volume":"211","author":"Miller","year":"1979","journal-title":"JAMA"},{"key":"10.1378\/chest.129.2.438_bib54","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0016-5085(19)30497-4","article-title":"Primary biliary cirrhosis: the prevalence of hypothyroidism and its relationship to thyroid autoantibodies and Sicca syndrome","volume":"78","author":"Crowe","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1378\/chest.129.2.438_bib55","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/BF01311724","article-title":"Increased incidence of hypothyroidism in primary biliary cirrhosis","volume":"28","author":"Elta","year":"1983","journal-title":"Dig Dis Sci"},{"key":"10.1378\/chest.129.2.438_bib56","first-page":"739","article-title":"Ascites, renal failure and electrolyte disorders in cirrhosis pathogenesis, diagnosis, and treatment","volume":"Vol 1","author":"Arroyo","year":"1992"},{"key":"10.1378\/chest.129.2.438_bib57","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1056\/NEJM198212163072504","article-title":"Potential role of increased sympathetic activity in impaired sodium and water excretion in cirrhosis","volume":"307","author":"Bichet","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.129.2.438_bib58","first-page":"247","article-title":"Water and electrolyte abnormalities in liver disease","author":"Merancy","year":"1963"},{"key":"10.1378\/chest.129.2.438_bib59","first-page":"198","article-title":"The kidney in liver cirrhosis","author":"Papper","year":"1963"},{"key":"10.1378\/chest.129.2.438_bib60","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0002-9149(77)90104-7","article-title":"Altered hemoglobin oxygen affinity with long-term propranolol therapy in patients with coronary artery disease","volume":"40","author":"Schrumpf","year":"1977","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.129.2.438_bib61","first-page":"469","article-title":"A human haemoglobin with lowered affinity and impaired heme-heme interaction","volume":"55","author":"Reisman","year":"1975","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.129.2.438_bib62","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajh.2830320108","article-title":"Warsaw (B42 Phe Val), an unstable hemoglobin with decreased oxygen affinity: I. Hematological and clinical expression","volume":"32","author":"Honig","year":"1989","journal-title":"Am J Hematol"},{"key":"10.1378\/chest.129.2.438_bib63","doi-asserted-by":"crossref","first-page":"44","DOI":"10.7326\/0003-4819-74-1-44","article-title":"Exercise with anemia: the role of left-shifted or right-shifted oxygen-hemoglobin equilibrium curve","volume":"74","author":"Oski","year":"1971","journal-title":"Am J Intern Med"},{"key":"10.1378\/chest.129.2.438_bib64","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1378\/chest.61.2_Supplement.25S","article-title":"Normal levels of 2,3-diphosphoglycerate red cells despite severe hypoxemia of chronic lung disease","volume":"61","author":"Edwards","year":"1972","journal-title":"Chest"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215387699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215387699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T07:20:49Z","timestamp":1615015249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215387699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0012369215387699"],"URL":"https:\/\/doi.org\/10.1378\/chest.129.2.438","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}