{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:14:26Z","timestamp":1792642466711,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1378\/chest.129.5.1219","type":"journal-article","created":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T20:57:27Z","timestamp":1147208247000},"page":"1219-1225","source":"Crossref","is-referenced-by-count":137,"title":["Impact of Alcohol Abuse in the Etiology and Severity of Community-Acquired Pneumonia"],"prefix":"10.1016","volume":"129","author":[{"given":"Andr\u00e9s","family":"de Roux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Cavalcanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angeles","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ewig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mensa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.129.5.1219_bib1","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1164\/ajrccm.163.7.at1010","article-title":"Guidelines for the management of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention","volume":"163","author":"Niederman","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.5.1219_bib2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/thorax.57.7.657","article-title":"BTS guidelines on CAP: community acquired pneumonia [letter]","volume":"57","author":"Gould","year":"2002","journal-title":"Thorax"},{"key":"10.1378\/chest.129.5.1219_bib3","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM199510193331607","article-title":"Medical disorders of alcoholism","volume":"333","author":"Lieber","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.129.5.1219_bib4","article-title":"World Health Organization Department of Substance Abuse","year":"2002","journal-title":"The global status report on alcohol"},{"key":"10.1378\/chest.129.5.1219_bib5","first-page":"79","author":"Sanchez-Pardo","year":"2002","journal-title":"Consumo de alcoh\u00f3l en la poblaci\u00f3n espa\u00f1ola"},{"key":"10.1378\/chest.129.5.1219_bib6","article-title":"Secretary of Health and Human Services","year":"1997","journal-title":"Ninth special report to the U.S. Congress on alcohol and health"},{"key":"10.1378\/chest.129.5.1219_bib7","first-page":"119","article-title":"The role of alcohol in severe pneumonia and acute lung injury","author":"Moss","year":"2001"},{"key":"10.1378\/chest.129.5.1219_bib8","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/alcalc\/34.6.830","article-title":"Consequences of alcohol consumption on host defense","volume":"19","author":"Szabo","year":"1999","journal-title":"Alcohol"},{"key":"10.1378\/chest.129.5.1219_bib9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/alcalc\/agh083","article-title":"Chronic alcoholism causes deleterious conditioning of innate immunity","volume":"34","author":"Frank","year":"2004","journal-title":"Alcohol"},{"key":"10.1378\/chest.129.5.1219_bib10","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1001\/archinte.1995.00430150137014","article-title":"High alcohol intake as a risk and prognostic factor for community-acquired pneumonia","volume":"155","author":"Fernandez-Sola","year":"1995","journal-title":"Arch Intern Med"},{"key":"10.1378\/chest.129.5.1219_bib11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1164\/ajrccm.160.2.9808045","article-title":"Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity","volume":"160","author":"Ruiz","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.5.1219_bib12","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1378\/chest.113.5.1195","article-title":"Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias","volume":"113","author":"Sopena","year":"1998","journal-title":"Chest"},{"key":"10.1378\/chest.129.5.1219_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/jama.1996.03530260048030","article-title":"Prognosis and outcomes of patients with community-acquired pneumonia: a meta-analysis","volume":"275","author":"Fine","year":"1996","journal-title":"JAMA"},{"key":"10.1378\/chest.129.5.1219_bib14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archinte.162.9.1059","article-title":"Causes of death for patients with community-acquired pneumonia: results from the Pneumonia Patient Outcomes Research Team cohort study","volume":"162","author":"Mortensen","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1378\/chest.129.5.1219_bib15","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1164\/ajrccm.160.3.9901107","article-title":"Severe community-acquired pneumonia: risk factors and follow-up epidemiology","volume":"160","author":"Ruiz","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.5.1219_bib16","author":"Balows","year":"1991","journal-title":"Manual of clinical microbiology"},{"key":"10.1378\/chest.129.5.1219_bib17","first-page":"339","article-title":"Microscopic and bacteriologic analysis of expectorated sputum","volume":"50","author":"Murray","year":"1975","journal-title":"Mayo Clin Proc"},{"key":"10.1378\/chest.129.5.1219_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1056\/NEJM199701233360402","article-title":"A prediction rule to identify low-risk patients with community-acquired pneumonia","volume":"336","author":"Fine","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.129.5.1219_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0376-8716(81)90108-3","article-title":"A longitudinal study of health risks associated with alcohol abuse in young navy men","volume":"8","author":"Kolb","year":"1981","journal-title":"Drug Alcohol Depend"},{"key":"10.1378\/chest.129.5.1219_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0376-8716(82)90043-6","article-title":"Alcohol-related morbidity among older career navy men","volume":"9","author":"Kolb","year":"1982","journal-title":"Drug Alcohol Depend"},{"key":"10.1378\/chest.129.5.1219_bib21","author":"Osler","year":"1905"},{"key":"10.1378\/chest.129.5.1219_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/infdis\/174.3.507","article-title":"Ethanol ingestion reduces antipneumococcal activity of rat pulmonary surfactant","volume":"174","author":"Rubins","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1378\/chest.129.5.1219_bib23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1530-0277.1993.tb00781.x","article-title":"Alcohol-induced inhibition of alveolar macrophage oxidant releasein vivoandin vitro","volume":"17","author":"Antony","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1378\/chest.129.5.1219_bib24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/infdis\/163.4.799","article-title":"A model of pneumococcal pneumonia in chronically intoxicated rats","volume":"163","author":"Davis","year":"1991","journal-title":"J Infect Dis"},{"key":"10.1378\/chest.129.5.1219_bib25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.1996.03530270034028","article-title":"Bacteremia withStreptococcus pneumoniae: implications for therapy and prevention; Franklin County Pneumonia Study Group","volume":"275","author":"Plouffe","year":"1996","journal-title":"JAMA"},{"key":"10.1378\/chest.129.5.1219_bib26","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1164\/ajrccm.159.6.9808049","article-title":"Pneumonia acquired in the community through drug-resistantStreptococcus pneumoniae","volume":"159","author":"Ewig","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.129.5.1219_bib27","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1086\/513628","article-title":"Multivariate analysis of risk factors for infection due to penicillin-resistant and multidrug-resistantStreptococcus pneumoniae: a multicenter study","volume":"24","author":"Clavo-Sanchez","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1378\/chest.129.5.1219_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1378\/chest.107.1.214","article-title":"Rapidly fatal outcome of bacteremicKlebsiella pneumoniaepneumonia in alcoholics","volume":"107","author":"Jong","year":"1995","journal-title":"Chest"},{"key":"10.1378\/chest.129.5.1219_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0163-4453(90)92258-M","article-title":"Klebsiella pneumoniaebacteraemia at an urban general hospital","volume":"20","author":"Feldman","year":"1990","journal-title":"J Infect"},{"key":"10.1378\/chest.129.5.1219_bib30","doi-asserted-by":"crossref","first-page":"d1314","DOI":"10.2741\/A842","article-title":"Pulmonary host defenses and alcohol","volume":"7","author":"Zhang","year":"2002","journal-title":"Front Biosci"},{"key":"10.1378\/chest.129.5.1219_bib31","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1086\/323661","article-title":"Acute ethanol intoxication suppresses lung chemokine production following infection withStreptococcus pneumoniae","volume":"184","author":"Boe","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1378\/chest.129.5.1219_bib32","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1086\/314763","article-title":"Granulocyte colony-stimulating factor modulates the pulmonary host response to endotoxin in the absence and presence of acute ethanol intoxication","volume":"179","author":"Zhang","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1378\/chest.129.5.1219_bib33","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1530-0277.1998.tb04294.x","article-title":"Alveolar macrophage release of tumor necrosis factor-\u03b1 in chronic alcoholics without liver disease","volume":"22","author":"Omidvari","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1378\/chest.129.5.1219_bib34","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1056\/NEJM200003093421002","article-title":"Cigarette smoking and invasive pneumococcal disease","volume":"342","author":"Nuorti","year":"2000","journal-title":"N Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215507009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215507009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T13:49:16Z","timestamp":1531144156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215507009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0012369215507009"],"URL":"https:\/\/doi.org\/10.1378\/chest.129.5.1219","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}