{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T12:57:13Z","timestamp":1677070633742},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1378\/chest.13-2026","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T14:30:57Z","timestamp":1387463457000},"page":"1039-1045","source":"Crossref","is-referenced-by-count":4,"title":["Substance P and Neurokinin 1 Receptors as Potential Therapeutic Targets in Children With OSA"],"prefix":"10.1016","volume":"145","author":[{"given":"David","family":"Gozal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinkwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie L.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Kheirandish-Gozal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.13-2026_bib1","author":"Kheirandish-Gozal","year":"2012"},{"issue":"3","key":"10.1378\/chest.13-2026_bib2","doi-asserted-by":"crossref","first-page":"e714","DOI":"10.1542\/peds.2012-1672","article-title":"Diagnosis and management of childhood obstructive sleep apnea syndrome","volume":"130","author":"Marcus","year":"2012","journal-title":"Pediatrics"},{"issue":"5","key":"10.1378\/chest.13-2026_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1164\/rccm.200912-1930OC","article-title":"Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: a multicenter retrospective study","volume":"182","author":"Bhattacharjee","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"25","key":"10.1378\/chest.13-2026_bib4","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMoa1215881","article-title":"A randomized trial of adenotonsillectomy for childhood sleep apnea","volume":"368","author":"Marcus","year":"2013","journal-title":"N Engl J Med"},{"issue":"3 pt 1","key":"10.1378\/chest.13-2026_bib5","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1542\/peds.102.3.616","article-title":"Sleep-disordered breathing and school performance in children","volume":"102","author":"Gozal","year":"1998","journal-title":"Pediatrics"},{"issue":"6","key":"10.1378\/chest.13-2026_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/MCP.0b013e3282ef6880","article-title":"Neurocognitive and behavioral morbidity in children with sleep disorders","volume":"13","author":"Gozal","year":"2007","journal-title":"Curr Opin Pulm Med"},{"issue":"20","key":"10.1378\/chest.13-2026_bib7","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/CIRCULATIONAHA.107.696823","article-title":"Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy","volume":"116","author":"Gozal","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"10.1378\/chest.13-2026_bib8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/HYPERTENSIONAHA.107.099762","article-title":"Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing","volume":"51","author":"Amin","year":"2008","journal-title":"Hypertension"},{"issue":"1","key":"10.1378\/chest.13-2026_bib9","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1542\/peds.2010-3431","article-title":"Elevated blood pressure during sleep and wake in children with sleep-disordered breathing","volume":"128","author":"Horne","year":"2011","journal-title":"Pediatrics"},{"issue":"10","key":"10.1378\/chest.13-2026_bib10","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1164\/rccm.200711-1670OC","article-title":"Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children","volume":"177","author":"Gozal","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1378\/chest.13-2026_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1378\/chest.126.1.13","article-title":"Differential expression of cysteinyl leukotriene receptors 1 and 2 in tonsils of children with obstructive sleep apnea syndrome or recurrent infection","volume":"126","author":"Goldbart","year":"2004","journal-title":"Chest"},{"issue":"2","key":"10.1378\/chest.13-2026_bib12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1203\/01.PDR.0000150722.34561.E6","article-title":"Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea","volume":"57","author":"Goldbart","year":"2005","journal-title":"Pediatr Res"},{"issue":"4","key":"10.1378\/chest.13-2026_bib13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1203\/PDR.0b013e3181b453e3","article-title":"Increased cellular proliferation and inflammatory cytokines in tonsils derived from children with obstructive sleep apnea","volume":"66","author":"Kim","year":"2009","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1378\/chest.13-2026_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1517\/13543784.2013.735230","article-title":"Novel pharmacological approaches for treatment of obstructive sleep apnea in children","volume":"22","author":"Kheirandish-Gozal","year":"2013","journal-title":"Expert Opin Investig Drugs"},{"issue":"5","key":"10.1378\/chest.13-2026_bib15","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1378\/chest.08-2102","article-title":"Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea","volume":"135","author":"Dayyat","year":"2009","journal-title":"Chest"},{"issue":"5","key":"10.1378\/chest.13-2026_bib16","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1183\/09031936.00130608","article-title":"Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoea","volume":"33","author":"Kheirandish-Gozal","year":"2009","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.13-2026_bib17","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1542\/peds.2007-3398","article-title":"Intranasal budesonide treatment for children with mild obstructive sleep apnea syndrome","volume":"122","author":"Kheirandish-Gozal","year":"2008","journal-title":"Pediatrics"},{"issue":"3","key":"10.1378\/chest.13-2026_bib18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1164\/rccm.200408-1064OC","article-title":"Leukotriene modifier therapy for mild sleep-disordered breathing in children","volume":"172","author":"Goldbart","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1378\/chest.13-2026_bib19","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1542\/peds.2012-0310","article-title":"Montelukast for children with obstructive sleep apnea: a double-blind, placebo-controlled study","volume":"130","author":"Goldbart","year":"2012","journal-title":"Pediatrics"},{"issue":"4","key":"10.1378\/chest.13-2026_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1203\/PDR.0b013e31814257ed","article-title":"Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea","volume":"62","author":"Goldbart","year":"2007","journal-title":"Pediatr Res"},{"issue":"12","key":"10.1378\/chest.13-2026_bib21","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/ppul.21109","article-title":"Pediatric obstructive sleep apnea: a potential late consequence of respiratory syncytial virus bronchiolitis","volume":"44","author":"Snow","year":"2009","journal-title":"Pediatr Pulmonol"},{"key":"10.1378\/chest.13-2026_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2466-11-41","article-title":"Tachykinin receptors antagonism for asthma: a systematic review","volume":"11","author":"Ramalho","year":"2011","journal-title":"BMC Pulm Med"},{"issue":"5","key":"10.1378\/chest.13-2026_bib23","first-page":"613","article-title":"Neurokinin 1 receptor antagonists\u2014current prospects","volume":"10","author":"Alvaro","year":"2007","journal-title":"Curr Opin Drug Discov Devel"},{"issue":"8","key":"10.1378\/chest.13-2026_bib24","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1517\/13543776.2010.495121","article-title":"Neurokinin-1 receptor antagonists: a comprehensive patent survey","volume":"20","author":"Huang","year":"2010","journal-title":"Expert Opin Ther Pat"},{"issue":"3","key":"10.1378\/chest.13-2026_bib25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1542\/peds.2005-1067","article-title":"Polysomnographic characteristics in normal preschool and early school-aged children","volume":"117","author":"Montgomery-Downs","year":"2006","journal-title":"Pediatrics"},{"issue":"6","key":"10.1378\/chest.13-2026_bib26","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1378\/chest.11-3164","article-title":"Screening of pediatric sleep-disordered breathing: a proposed unbiased discriminative set of questions using clinical severity scales","volume":"142","author":"Spruyt","year":"2012","journal-title":"Chest"},{"issue":"5","key":"10.1378\/chest.13-2026_bib27","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/lary.20147","article-title":"A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitis","volume":"119","author":"Serpero","year":"2009","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1378\/chest.13-2026_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1378\/chest.111.1.170","article-title":"High prevalence of allergic sensitization in children with habitual snoring and obstructive sleep apnea","volume":"111","author":"McColley","year":"1997","journal-title":"Chest"},{"issue":"2","key":"10.1378\/chest.13-2026_bib29","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1378\/chest.124.2.587","article-title":"Snoring in preschool children: prevalence and association with nocturnal cough and asthma","volume":"124","author":"Lu","year":"2003","journal-title":"Chest"},{"issue":"3","key":"10.1378\/chest.13-2026_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2500\/aap.2006.27.2855","article-title":"A review of the roles of allergic rhinitis in childhood obstructive sleep apnea syndrome","volume":"27","author":"Ng","year":"2006","journal-title":"Allergy Asthma Proc"},{"issue":"2","key":"10.1378\/chest.13-2026_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/alr.20104","article-title":"The prevalence of sleepiness and the risk of sleep-disordered breathing in children with positive allergy test","volume":"2","author":"Ishman","year":"2012","journal-title":"Int Forum Allergy Rhinol"},{"issue":"9","key":"10.1378\/chest.13-2026_bib32","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/ppul.21451","article-title":"Obstructive sleep apnea in poorly controlled asthmatic children: effect of adenotonsillectomy","volume":"46","author":"Kheirandish-Gozal","year":"2011","journal-title":"Pediatr Pulmonol"},{"issue":"1-3","key":"10.1378\/chest.13-2026_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2005.12.066","article-title":"Extending the understanding of sensory neuropeptides","volume":"533","author":"De Swert","year":"2006","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1378\/chest.13-2026_bib34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2174\/138945006778019318","article-title":"Tachykinins in the respiratory tract","volume":"7","author":"Groneberg","year":"2006","journal-title":"Curr Drug Targets"},{"issue":"4","key":"10.1378\/chest.13-2026_bib35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/cmi.2008.31","article-title":"Molecular basis of neuroimmune interaction in an in vitro coculture approach","volume":"5","author":"Nakanishi","year":"2008","journal-title":"Cell Mol Immunol"},{"key":"10.1378\/chest.13-2026_bib36","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.2741\/1484","article-title":"Tachykinin-mediated modulation of the immune response","volume":"9","author":"Bost","year":"2004","journal-title":"Front Biosci"},{"issue":"7","key":"10.1378\/chest.13-2026_bib37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00403-007-0767-4","article-title":"Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes","volume":"299","author":"Ikeda","year":"2007","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"10.1378\/chest.13-2026_bib38","first-page":"93","article-title":"Impact of substance P on cellular immunity","volume":"22","author":"Katsanos","year":"2008","journal-title":"J Biol Regul Homeost Agents"},{"issue":"9","key":"10.1378\/chest.13-2026_bib39","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1073\/pnas.0905877107","article-title":"TGF-beta regulates T-cell neurokinin-1 receptor internalization and function","volume":"107","author":"Beinborn","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1378\/chest.13-2026_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2466-12-79","article-title":"Inhaled corticosteroids inhibit substance P receptor expression in asthmatic rat airway smooth muscle cells","volume":"12","author":"Li","year":"2012","journal-title":"BMC Pulm Med"},{"issue":"1","key":"10.1378\/chest.13-2026_bib41","first-page":"51","article-title":"Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis","volume":"21","author":"Sch\u00e4per","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"4","key":"10.1378\/chest.13-2026_bib42","first-page":"298","article-title":"Effect of montelukast on the expression of neurokinin-1 receptor in young asthmatic rats with airway remodeling [in Chinese]","volume":"15","author":"Wei","year":"2013","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"issue":"7","key":"10.1378\/chest.13-2026_bib43","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ijporl.2005.01.035","article-title":"Cytokines locally produced by lymphocytes removed from the hypertrophic nasopharyngeal and palatine tonsils","volume":"69","author":"Komorowska","year":"2005","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"6","key":"10.1378\/chest.13-2026_bib44","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1001\/archoto.2011.86","article-title":"Effect of fluticasone furoate on interleukin 6 secretion from adenoid tissues in children with obstructive sleep apnea","volume":"137","author":"Esteitie","year":"2011","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1378\/chest.13-2026_bib45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0197-0186(01)00094-8","article-title":"Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells","volume":"40","author":"Cuesta","year":"2002","journal-title":"Neurochem Int"},{"issue":"6","key":"10.1378\/chest.13-2026_bib46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.npep.2003.09.005","article-title":"Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P","volume":"37","author":"Delgado","year":"2003","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1378\/chest.13-2026_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000094394","article-title":"Upregulation of tumor necrosis factor-alpha by stress and substance p in a murine model of allergic airway inflammation","volume":"13","author":"Joachim","year":"2006","journal-title":"Neuroimmunomodulation"},{"issue":"7","key":"10.1378\/chest.13-2026_bib48","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.1002535","article-title":"The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1\u03b2, IL-23, and TNF-like 1A expression by monocytes","volume":"186","author":"Cunin","year":"2011","journal-title":"J Immunol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215345967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215345967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:39:57Z","timestamp":1655944797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215345967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0012369215345967"],"URL":"https:\/\/doi.org\/10.1378\/chest.13-2026","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}