{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:09:51Z","timestamp":1791245391917,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1378\/chest.13-2967","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T09:34:01Z","timestamp":1399541641000},"page":"299-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Cerebral Oxygenation in Patients With OSA"],"prefix":"10.1016","volume":"146","author":[{"given":"Silvia","family":"Ulrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Nussbaumer-Ochsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Vasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Hasler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsogyal D.","family":"Latshang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Kohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Muehlemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad E.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1378\/chest.13-2967_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"9464","key":"10.1378\/chest.13-2967_bib2","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"issue":"12","key":"10.1378\/chest.13-2967_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrcardio.2010.145","article-title":"Mechanisms of vascular damage in obstructive sleep apnea","volume":"7","author":"Kohler","year":"2010","journal-title":"Nat Rev Cardiol"},{"issue":"6 pt 1","key":"10.1378\/chest.13-2967_bib4","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1164\/ajrccm.150.6.7952619","article-title":"Impairment of cerebral perfusion during obstructive sleep apneas","volume":"150","author":"B\u00e5lfors","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1378\/chest.13-2967_bib5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1183\/09031936.02.00265702","article-title":"Some factors affecting cerebral tissue saturation during obstructive sleep apnoea","volume":"20","author":"Valipour","year":"2002","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1378\/chest.13-2967_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/sleep\/33.2.205","article-title":"Nocturnal cerebral hemodynamics in snorers and in patients with obstructive sleep apnea: a near-infrared spectroscopy study","volume":"33","author":"Pizza","year":"2010","journal-title":"Sleep"},{"issue":"4","key":"10.1378\/chest.13-2967_bib7","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/STROKEAHA.109.574749","article-title":"Effects of hypobaric hypoxia on cerebral autoregulation","volume":"41","author":"Subudhi","year":"2010","journal-title":"Stroke"},{"issue":"4","key":"10.1378\/chest.13-2967_bib8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1089\/ham.2006.7.290","article-title":"Acetazolamide improves cerebral oxygenation during exercise at high altitude","volume":"7","author":"Vuyk","year":"2006","journal-title":"High Alt Med Biol"},{"issue":"5","key":"10.1378\/chest.13-2967_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/thx.2009.125849","article-title":"Exacerbation of sleep apnoea by frequent central events in patients with the obstructive sleep apnoea syndrome at altitude: a randomised trial","volume":"65","author":"Nussbaumer-Ochsner","year":"2010","journal-title":"Thorax"},{"issue":"1","key":"10.1378\/chest.13-2967_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1378\/chest.11-0375","article-title":"Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial","volume":"141","author":"Nussbaumer-Ochsner","year":"2012","journal-title":"Chest"},{"issue":"22","key":"10.1378\/chest.13-2967_bib11","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1001\/jama.2012.94847","article-title":"Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial","volume":"308","author":"Latshang","year":"2012","journal-title":"JAMA"},{"issue":"4","key":"10.1378\/chest.13-2967_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/ham.2011.1055","article-title":"How to treat patients with obstructive sleep apnea syndrome during an altitude sojourn","volume":"12","author":"Latshang","year":"2011","journal-title":"High Alt Med Biol"},{"issue":"2","key":"10.1378\/chest.13-2967_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1113\/expphysiol.2008.045575","article-title":"Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance","volume":"95","author":"Ainslie","year":"2010","journal-title":"Exp Physiol"},{"issue":"4","key":"10.1378\/chest.13-2967_bib14","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1378\/chest.109.4.916","article-title":"Changes in cerebral oxygenation and hemodynamics during obstructive sleep apneas","volume":"109","author":"Hayakawa","year":"1996","journal-title":"Chest"},{"issue":"3","key":"10.1378\/chest.13-2967_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11325-010-0367-y","article-title":"Changes in cerebral hemoglobin indices in obstructive sleep apnea syndrome with nasal continuous positive airway pressure treatment","volume":"15","author":"Matsuo","year":"2011","journal-title":"Sleep Breath"},{"issue":"suppl 1","key":"10.1378\/chest.13-2967_bib16","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/bja\/aep299","article-title":"Near-infrared spectroscopy as an index of brain and tissue oxygenation","volume":"103","author":"Murkin","year":"2009","journal-title":"Br J Anaesth"},{"issue":"14","key":"10.1378\/chest.13-2967_bib17","doi-asserted-by":"crossref","first-page":"10323","DOI":"10.1364\/OE.16.010323","article-title":"Wireless miniaturized in-vivo near infrared imaging","volume":"16","author":"Muehlemann","year":"2008","journal-title":"Opt Express"},{"issue":"2","key":"10.1378\/chest.13-2967_bib18","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.neuroimage.2010.08.079","article-title":"In vivo functional near-infrared spectroscopy measures mood-modulated cerebral responses to a positive emotional stimulus in sheep","volume":"54","author":"Muehlemann","year":"2011","journal-title":"Neuroimage"},{"key":"10.1378\/chest.13-2967_bib19","series-title":"A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects","year":"1968"},{"issue":"6","key":"10.1378\/chest.13-2967_bib20","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/sleep\/26.6.710","article-title":"Measurement of changes in cytochrome oxidase redox state during obstructive sleep apnea using near-infrared spectroscopy","volume":"26","author":"McGown","year":"2003","journal-title":"Sleep"},{"issue":"4","key":"10.1378\/chest.13-2967_bib21","doi-asserted-by":"crossref","first-page":"H1678","DOI":"10.1152\/ajpheart.00281.2011","article-title":"Cerebral and myocardial blood flow responses to hypercapnia and hypoxia in humans","volume":"301","author":"Beaudin","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1378\/chest.13-2967_bib22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1378\/chest.95.2.279","article-title":"Intracranial pressure and obstructive sleep apnea","volume":"95","author":"Jennum","year":"1989","journal-title":"Chest"},{"issue":"4","key":"10.1378\/chest.13-2967_bib23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1580\/1080-6032(1998)009[0198:NISITA]2.3.CO;2","article-title":"Near-infrared spectroscopy in the assessment of cerebral oxygenation at high altitude","volume":"9","author":"Imray","year":"1998","journal-title":"Wilderness Environ Med"},{"issue":"11","key":"10.1378\/chest.13-2967_bib24","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1161\/hs1101.098356","article-title":"Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head","volume":"32","author":"Al-Rawi","year":"2001","journal-title":"Stroke"},{"issue":"11","key":"10.1378\/chest.13-2967_bib25","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1161\/01.STR.0000244807.99073.ae","article-title":"Tissue oxygen index: thresholds for cerebral ischemia using near-infrared spectroscopy","volume":"37","author":"Al-Rawi","year":"2006","journal-title":"Stroke"},{"issue":"3","key":"10.1378\/chest.13-2967_bib26","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/sleep\/30.3.305","article-title":"Proton magnetic resonance spectroscopy study of brain metabolism in obstructive sleep apnoea syndrome before and after continuous positive airway pressure treatment","volume":"30","author":"Tonon","year":"2007","journal-title":"Sleep"},{"issue":"10","key":"10.1378\/chest.13-2967_bib27","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1164\/rccm.200201-050OC","article-title":"Brain morphology associated with obstructive sleep apnea","volume":"166","author":"Macey","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1378\/chest.13-2967_bib28","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/ALN.0b013e31824c00d7","article-title":"Impact of extracranial contamination on regional cerebral oxygen saturation: a comparison of three cerebral oximetry technologies","volume":"116","author":"Davie","year":"2012","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1378\/chest.13-2967_bib29","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1213\/01.ANE.0000072541.57132.BA","article-title":"Measuring cerebral oxygenation during normobaric hyperoxia: a comparison of tissue microprobes, near-infrared spectroscopy, and jugular venous oximetry in head injury","volume":"97","author":"McLeod","year":"2003","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1378\/chest.13-2967_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/bja\/aer324","article-title":"What comes first? The dynamics of cerebral oxygenation and blood flow in response to changes in arterial pressure and intracranial pressure after head injury","volume":"108","author":"Budohoski","year":"2012","journal-title":"Br J Anaesth"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215488191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215488191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:21:59Z","timestamp":1757920919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215488191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0012369215488191"],"URL":"https:\/\/doi.org\/10.1378\/chest.13-2967","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebral Oxygenation in Patients With OSA","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.13-2967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}