{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:20:03Z","timestamp":1767864003949,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1378\/chest.130.6.1695","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T18:31:20Z","timestamp":1166034680000},"page":"1695-1703","source":"Crossref","is-referenced-by-count":121,"title":["Pooled Clinical Trial Analysis of Tiotropium Safety"],"prefix":"10.1016","volume":"130","author":[{"given":"Steven","family":"Kesten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Jara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Wentworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Lanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.130.6.1695_bib1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0024-3205(98)00588-8","article-title":"Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease","volume":"64","author":"Disse","year":"1999","journal-title":"Life Sci"},{"key":"10.1378\/chest.130.6.1695_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1183\/09031936.02.00269802","article-title":"A long-term evaluation of once-daily tiotropium in chronic obstructive pulmonary disease","volume":"19","author":"Casaburi","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.130.6.1695_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1183\/09031936.02.00238702","article-title":"Improved health outcomes in patients with COPD during 1 yr\u2019s treatment with tiotropium","volume":"19","author":"Vincken","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.130.6.1695_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/thorax.58.5.399","article-title":"Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD","volume":"58","author":"Brusasco","year":"2003","journal-title":"Thorax"},{"key":"10.1378\/chest.130.6.1695_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1378\/chest.122.1.47","article-title":"A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol","volume":"122","author":"Donohue","year":"2002","journal-title":"Chest"},{"key":"10.1378\/chest.130.6.1695_bib6","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1183\/09031936.04.00116004","article-title":"Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD","volume":"23","author":"O\u2019Donnell","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.130.6.1695_bib7","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1378\/chest.128.3.1168","article-title":"Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD","volume":"128","author":"Maltais","year":"2005","journal-title":"Chest"},{"key":"10.1378\/chest.130.6.1695_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.7326\/0003-4819-143-5-200509060-00007","article-title":"Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator","volume":"143","author":"Niewoehner","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.130.6.1695_bib9","year":"2004"},{"key":"10.1378\/chest.130.6.1695_bib10","year":"2002"},{"key":"10.1378\/chest.130.6.1695_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1081\/COPD-120039560","article-title":"Electrocardiographic monitoring in COPD patients receiving tiotropium","volume":"1","author":"Morganroth","year":"2004","journal-title":"COPD"},{"key":"10.1378\/chest.130.6.1695_bib12","first-page":"29","article-title":"Measures of disease frequency","author":"Rothman","year":"1998"},{"key":"10.1378\/chest.130.6.1695_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/096228029300200202","article-title":"The statistical basis of meta-analysis","volume":"2","author":"Fleiss","year":"1993","journal-title":"Stat Methods Med Res"},{"key":"10.1378\/chest.130.6.1695_bib14","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1378\/chest.127.3.809","article-title":"Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD","volume":"127","author":"Casaburi","year":"2005","journal-title":"Chest"},{"key":"10.1378\/chest.130.6.1695_bib15","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1378\/chest.125.5.1726","article-title":"The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD","volume":"125","author":"Hasani","year":"2004","journal-title":"Chest"},{"key":"10.1378\/chest.130.6.1695_bib16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/thorax.58.10.855","article-title":"The effect of tiotropium bromide on circadian variation in airflow limitation in chronic obstructive pulmonary disease","volume":"58","author":"Calverley","year":"2003","journal-title":"Thorax"},{"key":"10.1378\/chest.130.6.1695_bib17","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1164\/ajrccm.161.4.9903044","article-title":"Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease","volume":"161","author":"Littner","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.130.6.1695_bib18","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1183\/09031936.95.08091506","article-title":"Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: a pharmacodynamic study in patients with chronic obstructive pulmonary disease","volume":"8","author":"Maesen","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.130.6.1695_bib19","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1378\/chest.124.5.1743","article-title":"Improvements in resting inspiratory capacity and hyperinflation with tiotropium in COPD with increased static lung volumes","volume":"124","author":"Celli","year":"2003","journal-title":"Chest"},{"key":"10.1378\/chest.130.6.1695_bib20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1183\/09031936.04.00085804","article-title":"Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD","volume":"23","author":"McNicholas","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.130.6.1695_bib21","first-page":"162","article-title":"Muscarinic receptor agonists and antagonists","author":"Brown","year":"2001"},{"key":"10.1378\/chest.130.6.1695_bib23","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1183\/09031936.04.00014304","article-title":"ATS\/ERS Task Force Committee Members. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS\/ERS position paper","volume":"23","author":"Celli","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.130.6.1695_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1164\/rccm.2110093","article-title":"Hospitalizations and mortality in the Lung Health Study","volume":"166","author":"Anthonisen","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.130.6.1695_bib25","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1001\/jama.1994.03520190043033","article-title":"Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1, the Lung Health Study","volume":"272","author":"Anthonisen","year":"1994","journal-title":"JAMA"},{"key":"10.1378\/chest.130.6.1695_bib26","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1164\/ajrccm.167.5.955","article-title":"Ipratropium and Lung Health Study","volume":"167","author":"Lanes","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.130.6.1695_bib27","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1378\/chest.125.6.2309","article-title":"Cardiovascular effects of B-agonists in patients with asthma and COPD","volume":"125","author":"Salpeter","year":"2004","journal-title":"Chest"},{"key":"10.1378\/chest.130.6.1695_bib28","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1056\/NEJMe058042","article-title":"Cox-2 inhibitors: lessons in drug safety","volume":"352","author":"Psaty","year":"2005","journal-title":"N Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215508891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215508891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T23:38:52Z","timestamp":1683675532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215508891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0012369215508891"],"URL":"https:\/\/doi.org\/10.1378\/chest.130.6.1695","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}