{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:37:43Z","timestamp":1760240263097,"version":"3.44.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1378\/chest.14-0215","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T13:27:21Z","timestamp":1414070841000},"page":"1376-1384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Isoniazid-Associated Hepatitis in Adults Infected With HIV Receiving 36 Months of Isoniazid Prophylaxis in Botswana"],"prefix":"10.1016","volume":"147","author":[{"given":"Zegabriel","family":"Tedla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh-Ly","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thabisa","family":"Sibanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samba","family":"Nyirenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tefera B.","family":"Agizew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Girde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles E.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taraz","family":"Samandari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"16","key":"10.1378\/chest.14-0215_bib1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1097\/00002030-200111090-00009","article-title":"Duration of efficacy of treatment of latent tuberculosis infection in HIV-infected adults","volume":"15","author":"Johnson","year":"2001","journal-title":"AIDS"},{"issue":"2","key":"10.1378\/chest.14-0215_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00002030-200101260-00011","article-title":"Long-term effect of preventive therapy for tuberculosis in a cohort of HIV-infected Zambian adults","volume":"15","author":"Quigley","year":"2001","journal-title":"AIDS"},{"issue":"4","key":"10.1378\/chest.14-0215_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/QAI.0b013e318218a713","article-title":"Incidence of tuberculosis in HIV-infected patients before and after starting combined antiretroviral therapy in 8 sub-Saharan African HIV programs","volume":"57","author":"Nicholas","year":"2011","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"5","key":"10.1378\/chest.14-0215_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.5588\/ijtld.10.0483","article-title":"Antiretroviral therapy and the control of HIV-associated tuberculosis. Will ART do it?","volume":"15","author":"Lawn","year":"2011","journal-title":"Int J Tuberc Lung Dis"},{"issue":"9777","key":"10.1378\/chest.14-0215_bib5","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/S0140-6736(11)60204-3","article-title":"6-month versus 36-month isoniazid preventive treatment for tuberculosis in adults with HIV infection in Botswana: a randomised, double-blind, placebo-controlled trial","volume":"377","author":"Samandari","year":"2011","journal-title":"Lancet"},{"year":"2011","key":"10.1378\/chest.14-0215_bib6"},{"issue":"6","key":"10.1378\/chest.14-0215_bib7","first-page":"991","article-title":"Isoniazid-related hepatitis: a US Public Health Service cooperative surveillance study","volume":"117","author":"Kopanoff","year":"1978","journal-title":"Am Rev Respir Dis"},{"issue":"8","key":"10.1378\/chest.14-0215_bib8","first-page":"224","article-title":"Severe isoniazid-associated liver injuries among people being treated for latent tuberculosis infection - United States, 2004-2008","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"2","key":"10.1378\/chest.14-0215_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1164\/rccm.200911-1783OC","article-title":"Isoniazid-associated hepatitis and antiretroviral drugs during tuberculosis prophylaxis in HIV-infected adults in Botswana","volume":"182","author":"Tedla","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1378\/chest.14-0215_bib10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1056\/NEJM199709183371201","article-title":"A trial of three regimens to prevent tuberculosis in Ugandan adults infected with the human immunodeficiency virus","volume":"337","author":"Whalen","year":"1997","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1378\/chest.14-0215_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1056\/NEJM199707313370505","article-title":"A controlled trial of isoniazid in people with anergy and human immunodeficiency virus infection who are at high risk for tuberculosis","volume":"337","author":"Gordin","year":"1997","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1378\/chest.14-0215_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7326\/0003-4819-84-2-181","article-title":"Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis","volume":"84","author":"Mitchell","year":"1976","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1378\/chest.14-0215_bib13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.7326\/0003-4819-71-6-1113","article-title":"Serum transaminase elevations and other hepatic abnormalities in patients receiving isoniazid","volume":"71","author":"Scharer","year":"1969","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1378\/chest.14-0215_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/QAI.0b013e3181c3cbf0","article-title":"Isoniazid tuberculosis preventive therapy in HIV-infected adults accessing antiretroviral therapy: a Botswana Experience, 2004-2006","volume":"54","author":"Mosimaneotsile","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1378\/chest.14-0215_bib15","first-page":"587","article-title":"A new method for the determination of N-acetyl isoniazid in urine of ambulatory patients","volume":"89","author":"Eidus","year":"1964","journal-title":"Am Rev Respir Dis"},{"issue":"1","key":"10.1378\/chest.14-0215_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.25011\/cim.v30i1.447","article-title":"The CAGE questionnaire for alcohol misuse: a review of reliability and validity studies","volume":"30","author":"Dhalla","year":"2007","journal-title":"Clin Invest Med"},{"issue":"4","key":"10.1378\/chest.14-0215_bib18","doi-asserted-by":"crossref","first-page":"e18435","DOI":"10.1371\/journal.pone.0018435","article-title":"Risk factors for non-adherence and loss to follow-up in a three-year clinical trial in Botswana","volume":"6","author":"Gust","year":"2011","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1378\/chest.14-0215_bib19","doi-asserted-by":"crossref","first-page":"e47400","DOI":"10.1371\/journal.pone.0047400","article-title":"Efficacy of a six-month versus a 36-month regimen for prevention of tuberculosis in HIV-infected people in India: a randomized clinical trial","volume":"7","author":"Swaminathan","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1378\/chest.14-0215_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1005136","article-title":"New regimens to prevent tuberculosis in adults with HIV infection","volume":"365","author":"Martinson","year":"2011","journal-title":"N Engl J Med"},{"issue":"suppl 5","key":"10.1378\/chest.14-0215_bib21","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/01.aids.0000391019.10661.66","article-title":"Adverse events with isoniazid preventive therapy: experience from a large trial","volume":"24","author":"Grant","year":"2010","journal-title":"AIDS"},{"issue":"3","key":"10.1378\/chest.14-0215_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1089\/aid.2011.0041","article-title":"Feasibility and efficacy of isoniazid prophylaxis for latent tuberculosis in HIV-infected clients patients in Thailand","volume":"28","author":"Khongphatthanayothin","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"10","key":"10.1378\/chest.14-0215_bib23","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S1473-3099(13)70187-7","article-title":"Effect of improved tuberculosis screening and isoniazid preventive therapy on incidence of tuberculosis and death in patients with HIV in clinics in Rio de Janeiro, Brazil: a stepped wedge, cluster-randomised trial","volume":"13","author":"Durovni","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"10.1378\/chest.14-0215_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cgh.2009.09.025","article-title":"Prevalence and factors associated with liver test abnormalities among human immunodeficiency virus-infected people","volume":"8","author":"Crum-Cianflone","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"17","key":"10.1378\/chest.14-0215_bib25","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJM199510263331706","article-title":"Drug-induced hepatotoxicity","volume":"333","author":"Lee","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.14-0215_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.pathol.1.110304.100230","article-title":"Immunobiology and pathogenesis of viral hepatitis","volume":"1","author":"Guidotti","year":"2006","journal-title":"Annu Rev Pathol"},{"issue":"3","key":"10.1378\/chest.14-0215_bib27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S1089-3261(02)00025-9","article-title":"Immune-mediated drug-induced liver disease","volume":"6","author":"Liu","year":"2002","journal-title":"Clin Liver Dis"},{"issue":"1","key":"10.1378\/chest.14-0215_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2796.2008.02043.x","article-title":"Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?","volume":"265","author":"Boasso","year":"2009","journal-title":"J Intern Med"},{"issue":"3","key":"10.1378\/chest.14-0215_bib29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jmv.21422","article-title":"Occult hepatitis B in people infected with HIV is associated with low CD4 counts and resolves during antiretroviral therapy","volume":"81","author":"Cohen Stuart","year":"2009","journal-title":"J Med Virol"},{"issue":"2","key":"10.1378\/chest.14-0215_bib30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/QAI.0b013e3182a60f7d","article-title":"HIV-HBV coinfection in Southern Africa and the effect of lamivudine-versus tenofovir-containing cART on HBV outcomes","volume":"64","author":"Hamers","year":"2013","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"3","key":"10.1378\/chest.14-0215_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/tropej\/fmp079","article-title":"Low rates of hepatotoxicity in HIV-infected children on anti-retroviral therapy with and without isoniazid prophylaxis","volume":"56","author":"Gray","year":"2010","journal-title":"J Trop Pediatr"},{"issue":"7","key":"10.1378\/chest.14-0215_bib32","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0895-4356(98)00033-X","article-title":"Comparison of three composite compliance indices in a trial of self-administered preventive therapy for tuberculosis in HIV-infected Ugandan adults","volume":"51","author":"Pekovic","year":"1998","journal-title":"J Clin Epidemiol"},{"issue":"RR11","key":"10.1378\/chest.14-0215_bib33","first-page":"1","article-title":"Treatment of tuberculosis","volume":"52","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"8","key":"10.1378\/chest.14-0215_bib34","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1164\/rccm.200510-1666ST","article-title":"An official ATS statement: hepatotoxicity of antituberculosis therapy","volume":"174","author":"Saukkonen","year":"2006","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215383641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215383641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:04:53Z","timestamp":1757919893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215383641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0012369215383641"],"URL":"https:\/\/doi.org\/10.1378\/chest.14-0215","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isoniazid-Associated Hepatitis in Adults Infected With HIV Receiving 36 Months of Isoniazid Prophylaxis in Botswana","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.14-0215","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}