{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:51:41Z","timestamp":1784710301694,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1378\/chest.15-0402","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T13:31:06Z","timestamp":1442496666000},"page":"809-815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Congenital Central Hypoventilation Syndrome"],"prefix":"10.1016","volume":"149","author":[{"given":"Aaron J.","family":"Charnay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne E.","family":"Antisdel-Lomaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Zelko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey M.","family":"Rand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha C.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally F.","family":"Vitez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer W.","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy D.","family":"Brogadir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Berry-Kravis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra E.","family":"Weese-Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1378\/chest.15-0402_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00005792-197011000-00003","article-title":"Failure of automatic control of ventilation (Ondine's curse). Report of an infant born with this syndrome and review of the literature","volume":"49","author":"Mellins","year":"1970","journal-title":"Medicine"},{"issue":"1","key":"10.1378\/chest.15-0402_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1164\/ajrccm.160.1.16010","article-title":"Idiopathic congenital central hypoventilation syndrome: diagnosis and management","volume":"160","author":"Weese-Mayer","year":"1999","journal-title":"Am J Resp Crit Care"},{"issue":"4","key":"10.1378\/chest.15-0402_bib3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/ng1130","article-title":"Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome","volume":"33","author":"Amiel","year":"2003","journal-title":"Nat Genet"},{"issue":"3","key":"10.1378\/chest.15-0402_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ajmg.a.20527","article-title":"Idiopathic congenital central hypoventilation syndrome: analysis of genes pertinent to early autonomic nervous system embryologic development and identification of mutations in PHOX2B","volume":"123A","author":"Weese-Mayer","year":"2003","journal-title":"Am J Med Genet A"},{"issue":"5","key":"10.1378\/chest.15-0402_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/jmg.2003.015412","article-title":"PHOX2B mutations and polyalanine expansions correlate with the severity of\u00a0the respiratory phenotype and associated symptoms in both congenital and late onset Central Hypoventilation syndrome","volume":"41","author":"Matera","year":"2004","journal-title":"J\u00a0Med Genet"},{"issue":"6","key":"10.1378\/chest.15-0402_bib6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1164\/rccm.200807-1069ST","article-title":"An\u00a0official ATS clinical policy statement: congenital central hypoventilation syndrome: genetic basis, diagnosis, and management","volume":"181","author":"Weese-Mayer","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1378\/chest.15-0402_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ppul.21170","article-title":"Congenital central hypoventilation syndrome: neurocognitive functioning in school age children","volume":"45","author":"Zelko","year":"2010","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"10.1378\/chest.15-0402_bib8","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S0022-3476(05)83038-0","article-title":"Medical and psychosocial outcome of children with congenital central hypoventilation syndrome","volume":"119","author":"Marcus","year":"1991","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1378\/chest.15-0402_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1542\/peds.80.3.375","article-title":"Long-term follow-up of children with congenital central hypoventilation syndrome","volume":"80","author":"Oren","year":"1987","journal-title":"Pediatrics"},{"issue":"3","key":"10.1378\/chest.15-0402_bib10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-3476(05)80902-3","article-title":"Neuropsychologic abnormalities in children with congenital central hypoventilation syndrome","volume":"120","author":"Silvestri","year":"1992","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1378\/chest.15-0402_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1152\/japplphysiol.01310.2013","article-title":"Residual chemosensitivity to\u00a0ventilatory challenges in genotyped congenital central hypoventilation syndrome","volume":"116","author":"Carroll","year":"2014","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1378\/chest.15-0402_bib12","series-title":"Bayley Scales of Infant Development","author":"Bayley","year":"1993"},{"key":"10.1378\/chest.15-0402_bib13","series-title":"Bayley Scales of Infant and Toddler Development","author":"Bayley","year":"2006"},{"issue":"2","key":"10.1378\/chest.15-0402_bib14","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1111\/j.1651-2227.2011.02517.x","article-title":"Comparison of the Bayley II Mental Developmental Index and the Bayley III Cognitive Scale: Are we measuring the same thing?","volume":"101","author":"Lowe","year":"2012","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1378\/chest.15-0402_bib15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1164\/ajrccm\/137.2.393","article-title":"Magnetic resonance imaging and computerized tomography in central hypoventilation","volume":"137","author":"Weese-Mayer","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.15-0402_bib16","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1164\/rccm.200605-607CR","article-title":"PHOX2B mutation-confirmed congenital central hypoventilation syndrome: presentation in adulthood","volume":"174","author":"Antic","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.15-0402_bib17","unstructured":"Mackintosh NJ. IQ and Human Intelligence. Oxford, UK: Oxford University Press."},{"issue":"6","key":"10.1378\/chest.15-0402_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.sleep.2010.03.008","article-title":"Images in sleep medicine. Altered cerebral blood flow in a\u00a0patient with congenital central hypoventilation syndrome","volume":"11","author":"Macey","year":"2010","journal-title":"Sleep Med"},{"issue":"2","key":"10.1378\/chest.15-0402_bib19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/ppul.21534","article-title":"Impaired behavioral and neurocognitive function in preschool children with obstructive sleep apnea","volume":"47","author":"Landau","year":"2012","journal-title":"Pediatr Pulmonol"},{"issue":"10","key":"10.1378\/chest.15-0402_bib20","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1002\/jnr.23083","article-title":"Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea","volume":"90","author":"Kumar","year":"2012","journal-title":"J\u00a0Neurosci Res"},{"issue":"8","key":"10.1378\/chest.15-0402_bib21","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1093\/cercor\/bhr235","article-title":"Decreased cortical thickness in central hypoventilation syndrome","volume":"22","author":"Macey","year":"2012","journal-title":"Cerebral Cortex"},{"issue":"5","key":"10.1378\/chest.15-0402_bib22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jpeds.2010.09.022","article-title":"The Bayley-III scale underestimates developmental delay in extremely premature and extremely low birth weight infants","volume":"157","author":"Msall","year":"2010","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1378\/chest.15-0402_bib23","doi-asserted-by":"crossref","first-page":"e993","DOI":"10.1542\/peds.2011-2166","article-title":"Overestimating neuroprotection in congenital heart disease: problems with Bayley III outcomes","volume":"128","author":"Msall","year":"2011","journal-title":"Pediatrics"},{"issue":"6","key":"10.1378\/chest.15-0402_bib24","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.ridd.2012.05.024","article-title":"Evaluating preterm infants\u00a0with the Bayley-III: patterns and correlates of development","volume":"33","author":"Greene","year":"2012","journal-title":"Res\u00a0Develop Disabil"},{"issue":"7","key":"10.1378\/chest.15-0402_bib25","first-page":"2107","article-title":"Re-evaluating preterm infants with the Bayley-III: patterns and predictors of change","volume":"34","author":"Greene","year":"2013","journal-title":"Res Develop\u00a0Disabil"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215000148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215000148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T23:50:05Z","timestamp":1653177005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215000148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0012369215000148"],"URL":"https:\/\/doi.org\/10.1378\/chest.15-0402","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Congenital Central Hypoventilation Syndrome","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.15-0402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}