{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:25:04Z","timestamp":1775769904758,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1969,1,1]],"date-time":"1969-01-01T00:00:00Z","timestamp":-31536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases of the Chest"],"published-print":{"date-parts":[[1969,1]]},"DOI":"10.1378\/chest.55.1.18","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T17:19:16Z","timestamp":1194455956000},"page":"18-24","source":"Crossref","is-referenced-by-count":9,"title":["A Controlled Study of Three Respiratory Stimulants in Chronic Respiratory Failure"],"prefix":"10.1016","volume":"55","author":[{"given":"Giulio","family":"Muiesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Augusto","family":"Sorbini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Solinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Casacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Petz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Motolese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.55.1.18_bib1","series-title":"Experience with Remeflin, a respiratory analeptic in the treatment of pulmonary insufficiency","first-page":"191","author":"Boyle","year":"1962"},{"key":"10.1378\/chest.55.1.18_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1001\/jama.1963.03060020029016","article-title":"Nikethamide as a respiratory analeptic","volume":"185","author":"Dulfano","year":"1963","journal-title":"J.A.M.A."},{"key":"10.1378\/chest.55.1.18_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0007-0971(67)80019-6","article-title":"A trial of intravenous Micoren, a respiratory stimulant, in respiratory failure","volume":"61","author":"Jain","year":"1967","journal-title":"Brit. J. Dis. Chest"},{"key":"10.1378\/chest.55.1.18_bib4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/bmj.1.5331.646","article-title":"Nikethamide for severe CO2 retention in exacerbations of chronic bronchitis","volume":"1","author":"Mcnicol","year":"1963","journal-title":"Brit. Med. J."},{"key":"10.1378\/chest.55.1.18_bib5","series-title":"Exp\u00e9rience dans le traitement de l\u2019insuffisance respiratoire des emphys\u00e9mateux","first-page":"123","author":"Perret","year":"1962"},{"key":"10.1378\/chest.55.1.18_bib6","series-title":"Place des analeptiques respiratoires dans le traitement de l\u2019insuffisance respiratoire aigu\u00eb des pulmonaires chroniques","first-page":"236","author":"Sadoul","year":"1962"},{"key":"10.1378\/chest.55.1.18_bib7","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1152\/jappl.1961.16.6.1129","article-title":"Continuous recording in vivo of arterial blood Po2 in dogs and man","volume":"16","author":"Said","year":"1961","journal-title":"J. Appl. Physiol."},{"key":"10.1378\/chest.55.1.18_bib8","series-title":"Place des analeptiques respiratoire dans le traitement de l\u2019insuffisance respiratoire des emphys\u00e9mateux","first-page":"158","author":"Campanacci","year":"1962"},{"key":"10.1378\/chest.55.1.18_bib9","first-page":"830","article-title":"Comparative study of three respiratory stimulants in chronic obstructive emphysema","volume":"87","author":"Canter","year":"1963","journal-title":"Amer. Rev. Resp. Dis."},{"key":"10.1378\/chest.55.1.18_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.0954-6820.1961.tb00222.x","article-title":"The effect of prethcamid in respiratory failure","volume":"170","author":"Lund-Johansen","year":"1961","journal-title":"Acta Med. Scand."},{"key":"10.1378\/chest.55.1.18_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0002-9343(65)90171-3","article-title":"Respiratory stimulants in obstructive lung disease","volume":"38","author":"Bader","year":"1965","journal-title":"Amer. J. Med."},{"key":"10.1378\/chest.55.1.18_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00000441-196709000-00004","article-title":"Analeptics: changing concepts, declining status","volume":"254","author":"Mark","year":"1967","journal-title":"Amer. J. Med. Sci."},{"key":"10.1378\/chest.55.1.18_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1378\/chest.52.2.141","article-title":"Statistical evaluation of the action of three different respiratory analeptics on pulmonary ventilation","volume":"52","author":"Muiesan","year":"1967","journal-title":"Dis. Chest"},{"key":"10.1378\/chest.55.1.18_bib14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/00000441-196212000-00011","article-title":"Evaluation of a new respiratory stimulant: dimefline","volume":"244","author":"Bailey","year":"1962","journal-title":"Amer. J. Med. Sci."},{"key":"10.1378\/chest.55.1.18_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/003591575805100207","article-title":"Oligopnea","volume":"51","author":"Hugh-Jones","year":"1958","journal-title":"Proc. Roy. Soc. Med."},{"key":"10.1378\/chest.55.1.18_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1136\/bmj.1.5117.274","article-title":"Effects of aminophylline, nikethamide, and sodium salicylate in respiratory failure","volume":"1","author":"Westlake","year":"1959","journal-title":"Brit. Med. J."},{"key":"10.1378\/chest.55.1.18_bib17","first-page":"294","article-title":"La dim\u00e9fline, nouvel analeptique respiratoire","volume":"92","author":"Baudraz","year":"1962","journal-title":"Schweiz. Med. Wschr."},{"key":"10.1378\/chest.55.1.18_bib18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.7326\/0003-4819-60-4-631","article-title":"An evaluation of Ethamivan as a respiratory stimulant in barbiturate intoxication, and alveolar hypoventilation in emphysema and obesity","volume":"60","author":"Cherniack","year":"1964","journal-title":"Ann. Intern. Med."},{"key":"10.1378\/chest.55.1.18_bib19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1152\/jappl.1955.7.5.472","article-title":"Gas stores of the body and the unsteady state","volume":"7","author":"Farhi","year":"1955","journal-title":"J. Appl. Physiol."},{"key":"10.1378\/chest.55.1.18_bib20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.7326\/0003-4819-41-1-172","article-title":"The work of breathing and its relation to respiratory acidosis","volume":"41","author":"Riley","year":"1954","journal-title":"Ann. Intern. Med."},{"key":"10.1378\/chest.55.1.18_bib21","first-page":"162","article-title":"The oxygen cost of breathing","volume":"67","author":"Cournand","year":"1954","journal-title":"Trans. Assoc. Amer. Physicians"},{"key":"10.1378\/chest.55.1.18_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0002-9343(64)90150-0","article-title":"Dichlorphenamide, a potent carbonic anhydrase inhibitor","volume":"36","author":"Dorris","year":"1964","journal-title":"Amer. J. Med."},{"key":"10.1378\/chest.55.1.18_bib23","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJM196212202672503","article-title":"Effect of ethamivan on alveolar ventilation in patients with chronic lung disease","volume":"267","author":"Rodman","year":"1962","journal-title":"New Eng. J. Med."},{"key":"10.1378\/chest.55.1.18_bib24","first-page":"421","article-title":"The effects of voluntary hyperventilation and intermittent positive pressure breathing on the distribution of ventilation and the distribution of perfusion","volume":"20","author":"Briscoe","year":"1961","journal-title":"Fed. Proc."},{"key":"10.1378\/chest.55.1.18_bib25","first-page":"421","article-title":"Effect of exercise on the distribution of ventilation and blood perfusion to the lung in emphysema","volume":"20","author":"Emmanuel","year":"1961","journal-title":"Fed. Proc."},{"key":"10.1378\/chest.55.1.18_bib26","series-title":"Experimental Designs","author":"Cochran","year":"1962"},{"key":"10.1378\/chest.55.1.18_bib27","series-title":"Experimental design","author":"Federer","year":"1963"},{"key":"10.1378\/chest.55.1.18_bib28","series-title":"Statistical principles in experimental design","author":"Winer","year":"1962"}],"container-title":["Diseases of the Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0096021715313340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0096021715313340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T22:49:30Z","timestamp":1588027770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0096021715313340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1969,1]]}},"alternative-id":["S0096021715313340"],"URL":"https:\/\/doi.org\/10.1378\/chest.55.1.18","relation":{},"ISSN":["0096-0217"],"issn-type":[{"value":"0096-0217","type":"print"}],"subject":[],"published":{"date-parts":[[1969,1]]}}}