{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:58:54Z","timestamp":1761058734599,"version":"3.44.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1970,3,1]],"date-time":"1970-03-01T00:00:00Z","timestamp":5097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1970,3,1]],"date-time":"1970-03-01T00:00:00Z","timestamp":5097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1970,3]]},"DOI":"10.1378\/chest.57.3.230","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T12:19:16Z","timestamp":1194437956000},"page":"230-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Atrial Septal Defect Associated with Skeletal Anomalies (Holt-Oram Syndrome)"],"prefix":"10.1016","volume":"57","author":[{"given":"H.C.","family":"Moguilevsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Dizadji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.B.","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.57.3.230_bib1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0140-6736(60)90676-0","article-title":"Multiple congenital anomaly caused by an extra autosome","volume":"1","author":"Patau","year":"1960","journal-title":"Lancet"},{"key":"10.1378\/chest.57.3.230_bib2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archinte.1964.00280100106016","article-title":"Trisomy 18","volume":"113","author":"Zellweger","year":"1964","journal-title":"Arch. Intern. Med."},{"key":"10.1378\/chest.57.3.230_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/hrt.22.3.331","article-title":"Congenital cardiac malformations in mongolism","volume":"22","author":"Berg","year":"1960","journal-title":"Brit. Heart J"},{"key":"10.1378\/chest.57.3.230_bib4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0022-3476(63)80368-6","article-title":"The XO syndrome: a study of the differentiated phenotype in 25 patients","volume":"63","author":"Lemli","year":"1963","journal-title":"J. Pediat."},{"key":"10.1378\/chest.57.3.230_bib5","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0022-3476(63)80190-0","article-title":"A phenotype female with 49 chromosomes, presumably XXXXX, a case report","volume":"63","author":"Kesaree","year":"1963","journal-title":"J. Pediat."},{"key":"10.1378\/chest.57.3.230_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-3476(63)80369-8","article-title":"An XXXXY male: case report and review","volume":"63","author":"Day","year":"1963","journal-title":"J. Pediat."},{"key":"10.1378\/chest.57.3.230_bib7","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0022-3476(63)80015-3","article-title":"Single atrium and the Ellis van Creveld syndrome","volume":"62","author":"Giknis","year":"1963","journal-title":"J. Pediat."},{"year":"1960","series-title":"Heritable disorders of connective tissue","author":"McKusick","key":"10.1378\/chest.57.3.230_bib8"},{"key":"10.1378\/chest.57.3.230_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/hrt.22.2.236","article-title":"Familial heart disease with skeletal malformation","volume":"22","author":"Holt","year":"1960","journal-title":"Brit. Heart J."},{"key":"10.1378\/chest.57.3.230_bib10","first-page":"380","article-title":"Extracardiac anomalies in association with congenital heart disease, analysis of 200 necropsy cases","volume":"5","author":"Wiland","year":"1956","journal-title":"Lab. Invest."},{"key":"10.1378\/chest.57.3.230_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9681(61)90038-8","article-title":"Medical genetics, 1960","volume":"14","author":"McKusick","year":"1961","journal-title":"J. Chronic Dis."},{"key":"10.1378\/chest.57.3.230_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1651-2227.1963.tb04085.x","article-title":"The syndrome of familial atrial septal defect, heart arrhythmia and hand malformation (Holt-Oram) in mother and son","volume":"52","author":"Zetterquist","year":"1963","journal-title":"Acta Paediat"},{"key":"10.1378\/chest.57.3.230_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000168096","article-title":"Familial congenital malformation of the heart and upper limbs, a syndrome of Holt-Oram","volume":"45","author":"Pruzanski","year":"1964","journal-title":"Cardiologia"},{"key":"10.1378\/chest.57.3.230_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/jama.1965.03090130008002","article-title":"The upper limb\u2014cardiovascular syndrome","volume":"193","author":"Lewis","year":"1965","journal-title":"J.A.M.A."},{"key":"10.1378\/chest.57.3.230_bib15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/01.CIR.34.1.65","article-title":"The syndrome of familial defects of heart and upper extremities (Holt-Oram syndrome)","volume":"34","author":"Massumi","year":"1966","journal-title":"Circulation"},{"key":"10.1378\/chest.57.3.230_bib16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1056\/NEJM196503042720901","article-title":"Congenital heart disease and upper extremity deformities\u2014a report of two families","volume":"272","author":"Holmes","year":"1965","journal-title":"New Eng. J. Med."},{"key":"10.1378\/chest.57.3.230_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1651-2227.1967.tb15384.x","article-title":"Holt-Oram syndrome","volume":"56","author":"Cascos","year":"1967","journal-title":"Acta Paediat. Scand."},{"key":"10.1378\/chest.57.3.230_bib18","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/0002-9149(67)90436-5","article-title":"Upper limb cardiovascular syndrome","volume":"19","author":"Starke","year":"1967","journal-title":"Amer. J. Cardiol."},{"key":"10.1378\/chest.57.3.230_bib19","first-page":"187","article-title":"Holt-Oram syndrome\u2014clinical and genetic study of a large family","volume":"18","author":"Gall","year":"1966","journal-title":"Amer. J. Hum. Genet."},{"key":"10.1378\/chest.57.3.230_bib20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/01.CIR.35.3.448","article-title":"Hereditary factors in atrial septal defect","volume":"35","author":"Nora","year":"1967","journal-title":"Circulation"},{"key":"10.1378\/chest.57.3.230_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jama.1961.63040140008011","article-title":"Features of palmar dermatoglyphics in congenital heart disease","volume":"176","author":"Hale","year":"1961","journal-title":"J.A.M.A."}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216503407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216503407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:56:02Z","timestamp":1757922962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216503407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,3]]}},"alternative-id":["S0012369216503407"],"URL":"https:\/\/doi.org\/10.1378\/chest.57.3.230","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[1970,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atrial Septal Defect Associated with Skeletal Anomalies (Holt-Oram Syndrome)","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.57.3.230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1970 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}