{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:30:24Z","timestamp":1775917824892,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1978,6,1]],"date-time":"1978-06-01T00:00:00Z","timestamp":265507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1978,6,1]],"date-time":"1978-06-01T00:00:00Z","timestamp":265507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1978,6]]},"DOI":"10.1378\/chest.73.6_supplement.958","type":"journal-article","created":{"date-parts":[[2008,10,11]],"date-time":"2008-10-11T09:23:22Z","timestamp":1223717002000},"page":"958-966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"S","title":["Effect of Respiratory Drugs on Mucociliary Clearance"],"prefix":"10.1016","volume":"73","author":[{"given":"Marvin A.","family":"Sackner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.73.6_Supplement.958_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0013-9351(74)90071-1","article-title":"The morphology of mucus in mammalian pulmonary airways","volume":"7","author":"Van As","year":"1974","journal-title":"Environ Res"},{"key":"10.1378\/chest.73.6_Supplement.958_bib2","first-page":"673","article-title":"Roentgenographic studies of the excretions of dusts from the lungs","volume":"39","author":"Barclay","year":"1938","journal-title":"Am J Roentgenol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib3","first-page":"214","article-title":"Clearance of tantalum from airways of different caliber in man evaluated by a roentgenographic method","volume":"107","author":"Gamsu","year":"1973","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1080\/00039896.1971.10665876","article-title":"Human tracheobronchial clearance studies","volume":"22","author":"Camner","year":"1971","journal-title":"Arch Environ Health"},{"key":"10.1378\/chest.73.6_Supplement.958_bib5","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1288\/00005537-197202000-00009","article-title":"Mucociliary function in dog's larynx and trachea","volume":"82","author":"Bridges","year":"1972","journal-title":"Laryngoscope"},{"key":"10.1378\/chest.73.6_Supplement.958_bib6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/jappl.1975.39.3.487","article-title":"Mucociliary tracheal transport rates in man","volume":"39","author":"Yeates","year":"1976","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/jappl.1973.34.4.495","article-title":"Estimation of tracheal mucous velocity by bronchofiberscopy","volume":"23","author":"Sackner","year":"1973","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib8","first-page":"67","article-title":"A new roentgenographic method for estimating mucous velocity in airways","volume":"115","author":"Friedman","year":"1977","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib9","first-page":"353","article-title":"Roentgen studies of the pathologic physiology of bronchial asthma","volume":"39","author":"Rigler","year":"1938","journal-title":"Am J Roentgenol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jcp.13.1.27","article-title":"The pathology of asthma, with special reference to changes in the bronchial mucosa","volume":"13","author":"Dunnill","year":"1960","journal-title":"J Clin Path"},{"key":"10.1378\/chest.73.6_Supplement.958_bib11","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1152\/jappl.1975.39.6.950","article-title":"Tracheal mucous transport in experimental asthma","volume":"39","author":"Wanner","year":"1975","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib12","first-page":"458","article-title":"Tracheal mucous velocity in normal man and patients with obstructive lung; effects of terbutaline","volume":"109","author":"Santa Cruz","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJM197503132921103","article-title":"Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma","volume":"2929","author":"McFadden","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.73.6_Supplement.958_bib14","first-page":"945","article-title":"Long term effects of metaproterenol in asthmatic children","volume":"115","author":"Sackner","year":"1977","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib15","first-page":"205","article-title":"Relationship of smoking history and pulmonary function tests to tracheal mucus velocity in nonsmokers, young smokers, ex-smokers, and patients with chronic bronchitis","volume":"117","author":"Goodman","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib16","first-page":"272","article-title":"Tracheobronchial clearance and chronic obstructive lung disease","volume":"54","author":"Camner","year":"1973","journal-title":"Scand J Resp Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib17","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/00039896.1973.10666405","article-title":"Tracheal mucous velocity in beagles after chronic exposure to cigarette smoke","volume":"27","author":"Wanner","year":"1973","journal-title":"Arch Environ Health"},{"key":"10.1378\/chest.73.6_Supplement.958_bib18","first-page":"733","article-title":"Tracheal mucociliary transport in patients with cystic fibrosis and its stimulation by terbutaline","volume":"111","author":"Wood","year":"1975","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/00039896.1976.10667194","article-title":"Increased mucociliary transport by adrenergic stimulation","volume":"39","author":"Camner","year":"1976","journal-title":"Arch Environ Health"},{"key":"10.1378\/chest.73.6_Supplement.958_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF02101588","article-title":"Die mukociliare Klarfunktion der Lunge unter B-adrenerger Stimulation","volume":"152","author":"Konietzko","year":"1975","journal-title":"Pneumonologie"},{"key":"10.1378\/chest.73.6_Supplement.958_bib21","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1152\/jappl.1976.41.2.146","article-title":"Effect of adrenergic agents and their mode of action on mucociliary clearance in man","volume":"41","author":"Foster","year":"1976","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib22","first-page":"379P","article-title":"The effects of isoproterenol, atropine, and disodium cromoglycate on ciliary activity and mucous flow measured in vivo in cats","volume":"35","author":"Blair","year":"1969","journal-title":"Br J Pharmacol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000193106","article-title":"The role of selective B2 adrenoceptor stimulants in the control of ciliary activity","volume":"31","author":"Van As","year":"1974","journal-title":"Respiration"},{"key":"10.1378\/chest.73.6_Supplement.958_bib24","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1159\/000193595","article-title":"Mucociliary function of the respiratory tract as influenced by drugs","volume":"31","author":"Iravani","year":"1974","journal-title":"Respiration"},{"key":"10.1378\/chest.73.6_Supplement.958_bib25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000193741","article-title":"Adrenergic compounds and the respiratory tract","volume":"33","author":"Melville","year":"1976","journal-title":"Respiration"},{"key":"10.1378\/chest.73.6_Supplement.958_bib26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1378\/chest.69.5.593","article-title":"Effect of beta-adrenergic agonists aerosolized by freon propellant on tracheal mucous velocity and cardiac output","volume":"69","author":"Sackner","year":"1976","journal-title":"Chest"},{"key":"10.1378\/chest.73.6_Supplement.958_bib27","first-page":"40","article-title":"Pulmonary effects of oxygen breathing","volume":"82","author":"Sackner","year":"1975","journal-title":"A six hour study in normal man. Ann Int Med"},{"key":"10.1378\/chest.73.6_Supplement.958_bib28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1152\/jappl.1972.33.6.719","article-title":"Role of vagus nerves in experimental asthma in allergic dogs","volume":"33","author":"Gold","year":"1972","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.73.6_Supplement.958_bib29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0140-6736(71)92432-9","article-title":"Inhibition of mucociliary clearance from the human lung by hyoscine","volume":"1","author":"Pavia","year":"1971","journal-title":"Lancet"},{"key":"10.1378\/chest.73.6_Supplement.958_bib30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00000542-197601000-00020","article-title":"Effects of atropine on velocity of tracheal mucus in anesthetized patients","volume":"44","author":"Annis","year":"1976","journal-title":"Anesthesiology"},{"key":"10.1378\/chest.73.6_Supplement.958_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000193824","article-title":"Effects of nebulized ipratropium bromide and atropine sulfate on tracheal mucous velocity and lung mechanics in anesthetized dogs","volume":"34","author":"Sackner","year":"1977","journal-title":"Respiration"},{"key":"10.1378\/chest.73.6_Supplement.958_bib32","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1136\/thx.30.5.543","article-title":"Effect of atropine on sputum production","volume":"30","author":"Lopez-Vidriero","year":"1975","journal-title":"Thorax"},{"key":"10.1378\/chest.73.6_Supplement.958_bib33","first-page":"736","article-title":"Evaluation of the clinical and physiologic effects of inhaled atropine sulfate in chronic bronchitis","volume":"109","author":"Klock","year":"1975","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib34","first-page":"823","article-title":"SCH-1000: A new anticholinergic bronchodilator","volume":"112","author":"Gross","year":"1975","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.73.6_Supplement.958_bib35","first-page":"415","article-title":"Mucociliary transport in central and intermediate size airways: Effect of aminophyllin","volume":"12","author":"Serafini","year":"1976","journal-title":"Bull Europ Physiopath Resp"},{"key":"10.1378\/chest.73.6_Supplement.958_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000193645","article-title":"Wirkung von Pharmaka Milieuanderungen auf Flimmertatigkeit der Atemwege","volume":"32","author":"Iravani J, Melville","year":"1975","journal-title":"Respiration"},{"key":"10.1378\/chest.73.6_Supplement.958_bib37","first-page":"15","article-title":"Bronchodilator activity of aerosols of prostaglandins E2 and E1 in asthmatic subjects","volume":"64","author":"Cuthbert","year":"1971","journal-title":"Proc R Soc Med"},{"key":"10.1378\/chest.73.6_Supplement.958_bib38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000193659","article-title":"Mucociliary activity in the respiratory tract as influenced by Prostaglandin E1","volume":"32","author":"Iravani","year":"1975","journal-title":"Respiration"},{"key":"10.1378\/chest.73.6_Supplement.958_bib39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0007-0971(74)90004-7","article-title":"Bromhexine and mucociliary clearance in chronic bronchitis","volume":"68","author":"Thomson","year":"1974","journal-title":"Br J Dis Chest"},{"key":"10.1378\/chest.73.6_Supplement.958_bib40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/thx.30.6.669","article-title":"No demonstrable effect of S-carbomethylcysteine on clearance of secretions from the human lung","volume":"30","author":"Thomson","year":"1975","journal-title":"Thorax"},{"key":"10.1378\/chest.73.6_Supplement.958_bib41","first-page":"1069","article-title":"Effect of beclomethasone diproprionate on tracheal mucous velocity","volume":"115","author":"Sackner","year":"1977","journal-title":"Am Rev Respir Dis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215413686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215413686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:06:24Z","timestamp":1757919984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215413686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,6]]}},"alternative-id":["S0012369215413686"],"URL":"https:\/\/doi.org\/10.1378\/chest.73.6_supplement.958","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1978,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Respiratory Drugs on Mucociliary Clearance","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.73.6_Supplement.958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1978 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}