{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:58:52Z","timestamp":1761058732584},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1983,6,1]],"date-time":"1983-06-01T00:00:00Z","timestamp":423273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1983,6]]},"DOI":"10.1378\/chest.83.6.904","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T18:25:26Z","timestamp":1194459926000},"page":"904-908","source":"Crossref","is-referenced-by-count":39,"title":["Bronchial Tree Penetration of Antibiotics"],"prefix":"10.1016","volume":"83","author":[{"given":"Bruce R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack L.","family":"LeFrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.83.6.904_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0007-0971(65)80014-6","article-title":"The bacteriology and chemotherapy of chronic bronchitis","volume":"59","author":"May","year":"1965","journal-title":"Br J Dis Chest"},{"key":"10.1378\/chest.83.6.904_bib2","first-page":"929","article-title":"Treatment of chronic bronchitis with ampicillin: some pharmacological observations","volume":"1","author":"May","year":"1965","journal-title":"Lancet"},{"key":"10.1378\/chest.83.6.904_bib3","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/thx.25.3.304","article-title":"Ampicillin levels in sputum, serum, and saliva","volume":"25","author":"Stewart","year":"1970","journal-title":"Thorax"},{"key":"10.1378\/chest.83.6.904_bib4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/thx.29.1.110","article-title":"Amoxycillin levels in sputum, serum and saliva","volume":"29","author":"Stewart","year":"1974","journal-title":"Thorax"},{"key":"10.1378\/chest.83.6.904_bib5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/jac\/2.3.279","article-title":"Bacampicillin in acute exacerbations of chronic bronchitis\u2014a dose-range study","volume":"2","author":"Maesen","year":"1976","journal-title":"J Antimicrob Chemother"},{"key":"10.1378\/chest.83.6.904_bib6","first-page":"249","article-title":"Twice daily dosage of bacampicillin in chronic bronchitis: a double-blind study","volume":"59","author":"Davies","year":"1978","journal-title":"Scand J Respir Dis"},{"key":"10.1378\/chest.83.6.904_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1378\/chest.61.2.117","article-title":"Endotracheal gentamicin in bronchial infections in patients with tracheostomy","volume":"61","author":"Klastersky","year":"1972","journal-title":"Chest"},{"key":"10.1378\/chest.83.6.904_bib8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1378\/chest.75.5.586","article-title":"Endotracheally administered antibiotics for gram-negative bronchopneumonia","volume":"75","author":"Klastersky","year":"1979","journal-title":"Chest"},{"issue":"suppl","key":"10.1378\/chest.83.6.904_bib9","first-page":"262","article-title":"Clinical significance of tissue penetration of antibiotics in the respiratory tract","volume":"14","author":"Lambert","year":"1978","journal-title":"Scand J Infect Dis"},{"key":"10.1378\/chest.83.6.904_bib10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/jcp.19.4.313","article-title":"Some observations on the penetration of antibiotics through mucus in vitro","volume":"19","author":"Saggers","year":"1966","journal-title":"J Clin Pathol"},{"key":"10.1378\/chest.83.6.904_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/adc.43.230.404","article-title":"In vivo penetration of antibiotics into sputum in cystic fibrosis","volume":"43","author":"Saggers","year":"1968","journal-title":"Arch Dis Child"},{"key":"10.1378\/chest.83.6.904_bib12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJM197602052940605","article-title":"Binding of drugs to serum albumin (first of two parts)","volume":"294","author":"Koch-Weser","year":"1976","journal-title":"N Engl J Med"},{"issue":"suppl","key":"10.1378\/chest.83.6.904_bib13","first-page":"580","article-title":"Use of combinations of trimethoprim and sulfamethoxazole in the treatment of chest infections","volume":"128","author":"Hughes","year":"1973","journal-title":"J Infect Dis"},{"key":"10.1378\/chest.83.6.904_bib14","first-page":"915","article-title":"Trimethoprim-sulfamethoxazole in chronic bronchitis","volume":"112","author":"Jordan","year":"1975","journal-title":"Can Med Assoc J"},{"key":"10.1378\/chest.83.6.904_bib15","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0140-6736(69)90539-X","article-title":"Rifamycin antibiotics in chronic purulent bronchitis","volume":"2","author":"Citron","year":"1969","journal-title":"Lancet"},{"key":"10.1378\/chest.83.6.904_bib16","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/AAC.3.6.703","article-title":"Cephalexin concentrations in sputum during acute respiratory infections","volume":"3","author":"Halprin","year":"1973","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1378\/chest.83.6.904_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/thx.20.3.219","article-title":"Penicillin levels in sputum","volume":"20","author":"Hafez","year":"1965","journal-title":"Thorax"},{"key":"10.1378\/chest.83.6.904_bib18","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0022-3476(71)80401-8","article-title":"TC carbenicillin and gentamicin: pharmacologic studies in patients with cystic fibrosis and Pseudomonas pulmonary infections","volume":"79","author":"Marks","year":"1971","journal-title":"J Pediatr"},{"key":"10.1378\/chest.83.6.904_bib19","author":"Goodhart","year":"1978"},{"issue":"suppl","key":"10.1378\/chest.83.6.904_bib20","first-page":"267","article-title":"Pharmacokinetic study of beta-lactam antimiotics in bronchial secretions","volume":"14","author":"Bergogne-Berezin","year":"1978","journal-title":"Scand J Infect Dis"},{"key":"10.1378\/chest.83.6.904_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0002-9343(75)90356-3","article-title":"Penetration of antimicrobial agents into bronchial secretions","volume":"59","author":"Wong","year":"1975","journal-title":"Am J Med"},{"key":"10.1378\/chest.83.6.904_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1128\/AAC.21.2.231","article-title":"Comparative trial of cefonicid and cefamandole in the therapy of community-acquired pneumonia","volume":"21","author":"Wallace","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"issue":"suppl 9","key":"10.1378\/chest.83.6.904_bib23","first-page":"34","article-title":"Cefuroxime: pharmacokinetic study in bronchial secretions","volume":"70","author":"Bergogne-Berezin","year":"1977","journal-title":"Proc R Soc Med"},{"issue":"suppl A","key":"10.1378\/chest.83.6.904_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/jac\/6.suppl_A.123","article-title":"Concentrations of cefotaxime in bronchial secretions","volume":"6","author":"Morel","year":"1980","journal-title":"J Antimicrob Chemother"},{"key":"10.1378\/chest.83.6.904_bib25","author":"Mouton","year":"1981"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215339337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215339337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T03:25:03Z","timestamp":1546485903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215339337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6]]}},"alternative-id":["S0012369215339337"],"URL":"https:\/\/doi.org\/10.1378\/chest.83.6.904","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}