{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:18:48Z","timestamp":1778703528917,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1989,5]]},"DOI":"10.1378\/chest.95.5.958","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T18:25:26Z","timestamp":1194459926000},"page":"958-961","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Ultrasonically Nebulized Distilled Water and Cold-air Hyperventilation Challenges in Asthmatic Patients"],"prefix":"10.1016","volume":"95","author":[{"given":"T. Shull","family":"Lemire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell J.","family":"Hopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Againdra K.","family":"Bewtra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicki M.","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Townley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.95.5.958_bib1","first-page":"179","article-title":"Methacholine sensitivity is unchanged during the refractory period following an exercise or isocapnic challenge","volume":"73","author":"Rosenthal","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.95.5.958_bib2","first-page":"31","article-title":"Eucapnic voluntary hyperventilation of compressed gas mixture","volume":"131","author":"Phillips","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.95.5.958_bib3","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1056\/NEJM197710062971402","article-title":"Enhancement of exercise-induced asthma by cold air","volume":"297","author":"Strauss","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.95.5.958_bib4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1152\/jappl.1979.46.3.476","article-title":"Hyperpnea and heat flux: initial reaction sequence in exercise-induced asthma","volume":"46","author":"Deal","year":"1979","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.95.5.958_bib5","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0091-6749(85)90745-6","article-title":"Issues in exercise-induced asthma","volume":"76","author":"Anderson","year":"1985","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.95.5.958_bib6","first-page":"86","article-title":"Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells","volume":"130","author":"Eggleston","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.95.5.958_bib7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2222.1986.tb00769.x","article-title":"Effect of hypo- and hyper-osmolarity on basophil histamine release","volume":"16","author":"Rimmer","year":"1986","journal-title":"Clin Allergy"},{"key":"10.1378\/chest.95.5.958_bib8","first-page":"1099","article-title":"The effects of ultrasonically produced aerosols on airways resistance in man","volume":"28","author":"Butler","year":"1968","journal-title":"Anesthesiology"},{"key":"10.1378\/chest.95.5.958_bib9","first-page":"61","article-title":"Airway response to osmolar challenge in asthma","volume":"125","author":"Elwood","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.95.5.958_bib10","first-page":"248","article-title":"Bronchoconstriction induced by distilled water","volume":"134","author":"Bascom","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.95.5.958_bib11","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0091-6749(86)90419-7","article-title":"Hyperosmolarity as the stimulus to asthma induced hyperventilation?","volume":"77","author":"Smith","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.95.5.958_bib12","first-page":"172","article-title":"Comparison of ultrasonically nebulized distilled water and hyperventilation with cold air in asthma","volume":"53","author":"Fabbri","year":"1984","journal-title":"Ann Allergy"},{"key":"10.1378\/chest.95.5.958_bib13","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0022-3476(85)80009-3","article-title":"Comparison of cold air, ultrasonic mist, and methacholine inhalations as tests of bronchial reactivity in normal and asthmatic children","volume":"107","author":"Galdes-Sebaldt","year":"1985","journal-title":"J Pediatr"},{"key":"10.1378\/chest.95.5.958_bib14","first-page":"659","article-title":"Reference spirometric values using techniques and equipment that meet ATS recommendations","volume":"124","author":"Crapo","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.95.5.958_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0091-6749(84)90279-3","article-title":"Specificity and sensitivity of methacholine inhalation challenge in normal and asthmatic children","volume":"74","author":"Hopp","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.95.5.958_bib16","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1378\/chest.90.5.726","article-title":"Increase in bronchial responsiveness to methacholine and late asthmatic response after the inhalation of ultrasonically nebulized distilled water","volume":"90","author":"Mattoli","year":"1986","journal-title":"Chest"},{"key":"10.1378\/chest.95.5.958_bib17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1164\/arrd.1986.134.5.990","article-title":"Cold air inhalation has a cumulative bronchospastic effect when inhaled in consecutive doses for progressively increasing degrees of ventilation","volume":"134","author":"Malo","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.95.5.958_bib18","first-page":"281","article-title":"Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to methacholine","volume":"125","author":"O\u2019Byrne","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.95.5.958_bib19","first-page":"226","article-title":"Correlation of methacholine-induced non-specific bronchial reactivity and cold air hyperventilation challenge","volume":"56","author":"Nair","year":"1986","journal-title":"Ann Allergy"},{"key":"10.1378\/chest.95.5.958_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0091-6749(87)80021-0","article-title":"Methacholine responsiveness increases after ultrasonically nebulized water but not after ultrasonically nebulized hypertonic saline in patients with asthma","volume":"79","author":"Smith","year":"1987","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.95.5.958_bib21","first-page":"621","article-title":"Airway responsiveness to cold air and hyperpnea in normal subjects and in those with hayfever and asthma","volume":"121","author":"Deal","year":"1980","journal-title":"Am Rev Respir Dis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216303816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216303816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T07:50:04Z","timestamp":1556956204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216303816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,5]]}},"alternative-id":["S0012369216303816"],"URL":"https:\/\/doi.org\/10.1378\/chest.95.5.958","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1989,5]]}}}