{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:02:44Z","timestamp":1770433364302,"version":"3.49.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1989,7]]},"DOI":"10.1378\/chest.96.1.205","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T18:25:26Z","timestamp":1194459926000},"page":"205-209","source":"Crossref","is-referenced-by-count":39,"title":["A Shift from Obstructive to Central Apnea"],"prefix":"10.1016","volume":"96","author":[{"given":"Eugene C.","family":"Fletcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.96.1.205_bib1","first-page":"676","article-title":"Periodic breathing and the pathogenesis of occlusive sleep apneas.","volume":"126","author":"Onal","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.96.1.205_bib2","first-page":"167","article-title":"Pathogenesis of apneas in hypersomnia sleep apnea syndrome.","volume":"125","author":"Onal","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.96.1.205_bib3","first-page":"1163","article-title":"A sleep-induced apneic threshold and its consequences.","volume":"133","author":"Dempsey","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.96.1.205_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0034-5687(82)90026-3","article-title":"Sleep apnea considered as a control system instability.","volume":"50","author":"Longobardo","year":"1982","journal-title":"Respir Physiol"},{"key":"10.1378\/chest.96.1.205_bib5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/jphysiol.1983.sp014906","article-title":"Mechanisms of hypoxia-induced periodic breathing during sleep in humans.","volume":"343","author":"Berssenbrugge","year":"1983","journal-title":"J Physiol"},{"key":"10.1378\/chest.96.1.205_bib6","first-page":"A334","article-title":"Effects of hypoxic-induced periodic breathing during sleep on upper airway obstruction [Abstract].","volume":"131","author":"Warner","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.96.1.205_bib7","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1056\/NEJM197305032881810","article-title":"Cheyne-Stokes breathing: an instability in physiologic control.","volume":"288","author":"Cherniack","year":"1973","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.96.1.205_bib8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1164\/arrd.1987.135.4.899","article-title":"Changes in inspiratory muscle electrical activity and upper airway resistance during periodic breathing induced by hypoxia during sleep.","volume":"135","author":"Hudgel","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.96.1.205_bib9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-86-6-725","article-title":"Continuous in-vivo monitoring of arterial oxygenation in chronic obstructive pulmonary disease.","volume":"86","author":"Flick","year":"1977","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.96.1.205_bib10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1152\/jappl.1983.54.3.632","article-title":"Nonapneic mechanisms of arterial oxygen desaturation during rapid eye-movement sleep.","volume":"54","author":"Fletcher","year":"1983","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.96.1.205_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0002-9343(85)90543-1","article-title":"Nocturnal oxyhemoglobin desaturation following tracheostomy for obstructive sleep apnea.","volume":"79","author":"Fletcher","year":"1985","journal-title":"Am J Med"},{"key":"10.1378\/chest.96.1.205_bib12","first-page":"831","article-title":"The effects of weight reduction on pulmonary function and the sensitivity of the respiratory center in obesity.","volume":"108","author":"Emirgil","year":"1973","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.96.1.205_bib13","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI105549","article-title":"Regional distribution of pulmonary ventilation and perfusion in obesity.","volume":"46","author":"Holley","year":"1967","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.96.1.205_bib14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1378\/chest.89.5.627","article-title":"Hypercapnia in the obstructive sleep apnea syndrome.","volume":"89","author":"Rapoport","year":"1986","journal-title":"Chest"},{"key":"10.1378\/chest.96.1.205_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1164\/arrd.1983.128.1.177","article-title":"Remission of severe obesity-hypoventilation syndrome after short-term treatment during sleep with nasal continuous positive airway pressure.","volume":"128","author":"Sullivan","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.96.1.205_bib16","first-page":"645","article-title":"Ventilatory response to carbon dioxide after removal of chronic upper airway obstruction.","volume":"102","author":"Ingram","year":"1970","journal-title":"Am Rev Respir Dis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215457745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215457745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T07:49:08Z","timestamp":1556956148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215457745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,7]]}},"alternative-id":["S0012369215457745"],"URL":"https:\/\/doi.org\/10.1378\/chest.96.1.205","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1989,7]]}}}