{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:35:30Z","timestamp":1758054930746,"version":"3.44.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1990,1]]},"DOI":"10.1378\/chest.97.1.46","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T13:25:26Z","timestamp":1194441926000},"page":"46-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Airways Responses to Ipratropium Bromide Do Not Vary with Time in Asthmatic Subjects"],"prefix":"10.1016","volume":"97","author":[{"given":"E.","family":"Ihre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"suppl 7","key":"10.1378\/chest.97.1.46_bib1","first-page":"103","article-title":"The action of Sch 1000 MDI on experimental bronchoconstriction induced by various types of non-specific and pharmacodynamic irritants in young asthmatics","volume":"51","author":"Nolte","year":"1975","journal-title":"Postgrad Med J"},{"issue":"suppl 7","key":"10.1378\/chest.97.1.46_bib2","first-page":"106","article-title":"The protective effect of inhaled Sch 1000 MDI on bronchoconstriction induced by serotonin, histamine, asetylcholine and propranolol","volume":"51","author":"De","year":"1975","journal-title":"Postgrad Med J"},{"key":"10.1378\/chest.97.1.46_bib3","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1172\/JCI105671","article-title":"Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease.)","volume":"46","author":"Simonsson","year":"1967","journal-title":"Clin Invest"},{"key":"10.1378\/chest.97.1.46_bib4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0007-0971(81)90009-7","article-title":"The effect of ipratropium and fenoterol on methacholine- and histamine-induced bronchoconstriction","volume":"75","author":"Bandouvakis","year":"1981","journal-title":"Br J Dis Chest"},{"key":"10.1378\/chest.97.1.46_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1152\/jappl.1983.54.1.130","article-title":"Effect of route of atropine delivery on bronchospasm from cold air and methacholine","volume":"54","author":"Sheppard","year":"1983","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.1.46_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2222.1984.tb02184.x","article-title":"Protection by ipratropium bromide and metaproterenol against methacholine and histamine bronchocontriction","volume":"24","author":"Nair","year":"1984","journal-title":"Clin Allergy"},{"key":"10.1378\/chest.97.1.46_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/02770908709073190","article-title":"Ipratropium bromide: bronchodilator action and effect on methacholine-induced bronchoconstriction","volume":"24","author":"Larsson","year":"1987","journal-title":"J Asthma"},{"key":"10.1378\/chest.97.1.46_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/thx.32.4.429","article-title":"Protective effect of drugs on histamine-induced asthma","volume":"32","author":"Cockcroft","year":"1977","journal-title":"Thorax"},{"key":"10.1378\/chest.97.1.46_bib9","first-page":"449","article-title":"Effect of atropine on experimentally-induced airway obstruction in man","volume":"17","author":"Eiser","year":"1982","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1378\/chest.97.1.46_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0091-6749(84)90488-3","article-title":"Variable inhibition of histamine-induced bronchoconstriction by atropine in subjects with asthma","volume":"73","author":"Sheppard","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.97.1.46_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2222.1978.tb00471.x","article-title":"Effect of Sch1000 in allergen-induced asthma","volume":"8","author":"Cockcroft","year":"1978","journal-title":"Clin Allergy"},{"key":"10.1378\/chest.97.1.46_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1152\/jappl.1972.32.6.823","article-title":"Inhibition of antigen-induced bronchoconstriction by atropine in asthmatic patients","volume":"32","author":"Yu","year":"1972","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.1.46_bib13","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1152\/jappl.1982.53.6.1576","article-title":"Doseresponse effects of atropine on thermal stimulus-response relationships in asthma","volume":"53","author":"Griffin","year":"1982","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.1.46_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/jappl.1982.53.1.169","article-title":"Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine","volume":"53","author":"Sheppard","year":"1982","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.1.46_bib15","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/thx.38.7.506","article-title":"The bronchial response to cold air challenge: evidence for different mechanisms in normal and asthmatic subjects","volume":"38","author":"Heaton","year":"1983","journal-title":"Thorax"},{"key":"10.1378\/chest.97.1.46_bib16","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0091-6749(76)90207-4","article-title":"The effect of atropine and albuterol aerosols on the human bronchial response to histamine","volume":"58\/5","author":"Casterline","year":"1976","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.97.1.46_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0091-6749(85)90810-3","article-title":"The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine","volume":"76","author":"O'Byrne","year":"1985","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.97.1.46_bib18","first-page":"371","article-title":"The effect of atropine on acute antigen-mediated airway constriction in subjects with allergic asthma","volume":"115","author":"Fish","year":"1977","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.97.1.46_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0091-6749(78)90089-1","article-title":"Bronchial hyperreactivity to histamine and methacholine in asthmatic children after inhalation of SCH 1000 and chlorpheniramine maleate","volume":"62","author":"Woenne","year":"1978","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.97.1.46_bib20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1152\/jappl.1977.42.4.600","article-title":"Role of the parasympathetic system in antigen-induced bronchospasm","volume":"42","author":"Rosenthal","year":"1977","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.1.46_bib21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1378\/chest.90.4.485","article-title":"Reduction of nocturnal asthma by an inhaled anticholinergic drug","volume":"90","author":"Coe","year":"1986","journal-title":"Chest"},{"key":"10.1378\/chest.97.1.46_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.0954-6820.1963.tb16520.x","article-title":"Spirometric studies in normal subjects, I: forced expirograms in subjects between 7 and 70 years of age","volume":"173","author":"Berglund","year":"1963","journal-title":"Acta Med Scand"},{"key":"10.1378\/chest.97.1.46_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1152\/jappl.1983.54.1.134","article-title":"Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs","volume":"54","author":"Holtzman","year":"1983","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.1.46_bib24","first-page":"986","article-title":"Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma","volume":"132","author":"Howarth","year":"1985","journal-title":"Am Rev Respir Dis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215405823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215405823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:06:49Z","timestamp":1757920009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215405823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["S0012369215405823"],"URL":"https:\/\/doi.org\/10.1378\/chest.97.1.46","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[1990,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Airways Responses to Ipratropium Bromide Do Not Vary with Time in Asthmatic Subjects","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.97.1.46","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1990 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}