{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:44:13Z","timestamp":1771627453146,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1990,3]]},"DOI":"10.1378\/chest.97.3_supplement.70s","type":"journal-article","created":{"date-parts":[[2008,10,11]],"date-time":"2008-10-11T13:23:22Z","timestamp":1223731402000},"page":"70S-76S","source":"Crossref","is-referenced-by-count":6,"special_numbering":"S","title":["Lessons from High Altitude"],"prefix":"10.1016","volume":"97","author":[{"given":"John V.","family":"Weil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.97.3_Supplement.70S_bib1","first-page":"44","article-title":"Hematologic response to medium altitude","volume":"63","author":"Okin","year":"1966","journal-title":"Rocky Mtn Med J"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib2","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI105854","article-title":"The red cell mass-arterial oxygen relationship in normal man","volume":"47","author":"Weil","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1098\/rstb.1923.0008","article-title":"Observations upon the effect of high altitude on the physiologic processes of the human body carried out in the Peruvian Andes chiefly at Cerro de Pasco","volume":"211","author":"Barcroft","year":"1922","journal-title":"Philos Trans R Soc London"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/jappl.1957.10.1.81","article-title":"Respiratory adaptations to chronic high altitude hypoxia","volume":"10","author":"Chiodi","year":"1957","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0034-5687(66)90049-1","article-title":"Respiratory insensitivity to hypoxia in chronically hypoxic man","volume":"1","author":"Severinghaus","year":"1966","journal-title":"Respir Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1152\/jappl.1968.25.3.221","article-title":"Respiratory insensitivity to acute hypoxia persisting after correction of tetralogy of Fallot","volume":"25","author":"Sorensen","year":"1968","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1172\/JCI106472","article-title":"Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude","volume":"50","author":"Weil","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1152\/jappl.1972.32.1.44","article-title":"Hypoxic and hypercapnic ventilatory drives in children native to high altitude","volume":"32","author":"Byrne-Quinn","year":"1972","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib9","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1152\/jappl.1975.38.6.1095","article-title":"Normal values for hypoxic and hypercapnic ventilatory drives in man","volume":"38","author":"Hirshman","year":"1975","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib10","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1152\/jappl.1977.43.6.1019","article-title":"Variability of ventilatory responses to hypoxia and hypercapnia","volume":"43","author":"Sahn","year":"1977","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib11","doi-asserted-by":"crossref","first-page":"62225","DOI":"10.7326\/0003-4819-80-5-622","article-title":"Asthma associated with decreased hypoxic ventilatory drive: a family study","volume":"80","author":"Hudgel","year":"1974","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM197610142951604","article-title":"Respiratory failure associated with familial depression of ventilatory response to hypoxia and hypercapnia","volume":"295","author":"Moore","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1152\/jappl.1971.30.1.91","article-title":"Ventilatory control in the athlete","volume":"30","author":"Byrne-Quinn","year":"1971","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib14","first-page":"497","article-title":"Ventilatory response to carbon dioxide in young athletes: a family study","volume":"113","author":"Saunders","year":"1976","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1152\/jappl.1978.44.3.464","article-title":"Familial aspects of decreased hypoxic drive in endurance athletes","volume":"44","author":"Scoggin","year":"1978","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1172\/JCI109093","article-title":"Hereditary aspects of decreased hypoxic response","volume":"21","author":"Collins","year":"1978","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/jappl.1982.52.3.537","article-title":"Control of breathing in young twins","volume":"52","author":"Kawakami","year":"1982","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib18","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1152\/jappl.1987.63.5.1884","article-title":"Interindividual variation of ventilatory response to hypoxia is associated with variation in sensitivity of peripheral chemoreceptors","volume":"63","author":"Vizek","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib19","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1152\/jappl.1984.56.6.1478","article-title":"Relationship of hypoxic ventilatory response to exercise performance on Mount Everest","volume":"56","author":"Schoene","year":"1984","journal-title":"J Appl Physiol: Respirat Environ Exer Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1152\/jappl.1986.61.2.500","article-title":"Control of ventilation in extreme-altitude climbers","volume":"61","author":"Masuyama","year":"1986","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib21","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1152\/jappl.1982.53.4.886","article-title":"Control of ventilation in climbers to extreme altitude","volume":"53","author":"Schoene","year":"1982","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib22","first-page":"179","article-title":"Ventilation in human populations native to high altitude","author":"Hackett","year":"1984"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0034-5687(70)90107-6","article-title":"Hypoxia and hypercapnia as respiratory stimulants and depressants","volume":"11","author":"Cherniack","year":"1970","journal-title":"Respir Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000194206","article-title":"Ventilatory acclimatization to high altitude is prevented by CO2 breathing","volume":"39","author":"Cruz","year":"1980","journal-title":"Respiration"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib25","first-page":"124s","article-title":"Assessment of ventilatory response to hypoxia: methods and interpretation","volume":"70","author":"Weil","year":"1976","journal-title":"Chest"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib26","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1152\/jappl.1987.63.4.1658","article-title":"Biphasic ventilatory response of adult cats to sustained hypoxia has central origin","volume":"63","author":"Vizek","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1152\/physrev.1982.62.1.262","article-title":"Mediation of ventilatory adaptations","volume":"62","author":"Dempsey","year":"1982","journal-title":"Physiol Rev"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/cphy.cp030221","article-title":"Ventilatory control at high altitude","author":"Weil","year":"1986"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib29","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1152\/jappl.1984.56.3.602","article-title":"Hypocapnia and sustained hypoxia blunt ventilation on arrival at high altitude","volume":"56","author":"Huang","year":"1984","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1152\/jappl.1987.63.1.401","article-title":"Altitude acclimatization: influence on periodic breathing and chemoresponsiveness during sleep","volume":"63","author":"White","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib31","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1152\/jappl.1986.60.3.1011","article-title":"Ventilatory acclimatization to hypoxia is not dependent on cerebral hypocapnic alkalosis","volume":"60","author":"Bisgard","year":"1986","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib32","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1152\/jappl.1985.58.6.1874","article-title":"Ventilatory acclimatization to hypoxia is not dependent on arterial hypoxemia","volume":"58","author":"Busch","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib33","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1152\/jappl.1987.63.6.2403","article-title":"Increased carotid body hypoxic sensitivity during acclimatization to hypobaric hypoxia","volume":"63","author":"Vizek","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/bmj.3.5620.707","article-title":"Relation between airways obstruction and CO2 tension in chronic obstructive airways disease","volume":"2","author":"Lane","year":"1968","journal-title":"Br Med J"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/00039896.1963.10663506","article-title":"O'Neill. The fighter versus the nonfighter\u2014control of ventilation in chronic obstructive pulmonary disease","volume":"7","author":"Robin","year":"1963","journal-title":"Arch Environ Health"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1056\/NEJM196807112790201","article-title":"Drive and performance of the ventilatory apparatus in chronic obstructive lung disease","volume":"279","author":"Lourenco","year":"1968","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI108665","article-title":"Effects of hypercapnia and inspiratory flow-resistive loading on respiratory activity in chronic airways obstruction","volume":"59","author":"Altose","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib38","first-page":"199","article-title":"Assessment of responsiveness to carbon dioxide in patients with chronic airways obstruction by rate of isometric inspiratory pressure development","volume":"50","author":"Matthews","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib40","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJM197803092981001","article-title":"Weil JV Hypoventilation in obstructive lung disease: the role of familial factors","volume":"298","author":"Mountain","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib41","first-page":"3","article-title":"Familial aspects of ventilatory control in patients with chronic obstructive pulmonary disease","volume":"129","author":"Fleetham","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib42","first-page":"420","article-title":"Familial factors affecting arterial blood gas values and respiratory chemosensitivity in chronic obstructive pulmonary disease","volume":"125","author":"Kawakami","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0034-5687(80)90046-8","article-title":"Oxygen transport during progressive hypoxia in high-altitude and sea-level waterfowl","volume":"39","author":"Black","year":"1980","journal-title":"Respir Physiol"},{"key":"10.1378\/chest.97.3_Supplement.70S_bib39","first-page":"21","article-title":"Ventilatory control in patients with hypoxemia due to obstructive lung disease","volume":"120","author":"Bradley","year":"1979","journal-title":"Am Rev Respir Dis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216318967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216318967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T11:13:47Z","timestamp":1684581227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216318967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["S0012369216318967"],"URL":"https:\/\/doi.org\/10.1378\/chest.97.3_supplement.70s","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}