{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:06:45Z","timestamp":1758820005173},"reference-count":15,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1990,12]]},"DOI":"10.1378\/chest.98.6.1440","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T18:25:26Z","timestamp":1194459926000},"page":"1440-1444","source":"Crossref","is-referenced-by-count":12,"title":["The Effect of Multiple-Dose Oral Lomefloxacin on Theophylline Metabolism in Man"],"prefix":"10.1016","volume":"98","author":[{"given":"Giel J.A.","family":"Wijnands","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.","family":"Cornel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Martea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom B.","family":"Vree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.98.6.1440_bib1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1128\/AAC.31.6.854","article-title":"In vitro and in vivo activity of NY-198, a new difluorinated quinolone","volume":"31","author":"Hirose","year":"1987","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1378\/chest.98.6.1440_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0140-6736(84)90283-6","article-title":"Enoxacin raises plasma theophylline concentrations","volume":"2","author":"Wijnands","year":"1984","journal-title":"Lancet"},{"key":"10.1378\/chest.98.6.1440_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2125.1985.tb05115.x","article-title":"Enoxacin decreases the clearance of theophylline in man","volume":"20","author":"Wijnands","year":"1985","journal-title":"Br J Clin Pharmacol"},{"key":"10.1378\/chest.98.6.1440_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1365-2125.1986.tb02957.x","article-title":"The influence of quinolone derivatives on theophylline clearance","volume":"22","author":"Wijnands","year":"1986","journal-title":"Br J Clin Pharmacol"},{"key":"10.1378\/chest.98.6.1440_bib5","first-page":"32","article-title":"Serum theophylline levels are increased by ciprofloxacin (Bay 9867), a new quinolone antibiotic","volume":"88","author":"Raoof","year":"1985","journal-title":"Chest"},{"key":"10.1378\/chest.98.6.1440_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/AAC.32.1.75","article-title":"Impact of ciprofloxacin on theophylline clearance and steady-state concentrations in serum","volume":"32","author":"Schwartz","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1378\/chest.98.6.1440_bib7","first-page":"289","article-title":"Interaction of quinolones with the theophylline metabolism in man: investigations with lomefloxacin and pipemidic acid","volume":"27","author":"Staib","year":"1989","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"10.1378\/chest.98.6.1440_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/jac\/22.Supplement_C.109","article-title":"Interaction between the fluoroquinolones and the bronchodilator theophylline","volume":"22","author":"Wijnands","year":"1988","journal-title":"J Antimicrob Chemother"},{"key":"10.1378\/chest.98.6.1440_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00637553","article-title":"Enoxacin: a potent inhibitor of theophylline metabolism","volume":"33","author":"Beckmann","year":"1987","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1378\/chest.98.6.1440_bib10","first-page":"584","article-title":"Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography","volume":"85","author":"Thomson","year":"1974","journal-title":"J Lab Clin Med"},{"issue":"6c","key":"10.1378\/chest.98.6.1440_bib11","first-page":"47","article-title":"Drug-drug interactions affecting fluoroquinolones","volume":"87","author":"Wijnands","year":"1989","journal-title":"Am J Med"},{"key":"10.1378\/chest.98.6.1440_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/00498258009033729","article-title":"Metabolites of pipemidic acid in human urine","volume":"10","author":"Kurobe","year":"1980","journal-title":"Xenobiotica"},{"key":"10.1378\/chest.98.6.1440_bib13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/BF00637602","article-title":"4-Quinolones inhibit biotransformation of caffeine","volume":"35","author":"Harder","year":"1988","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1378\/chest.98.6.1440_bib14","first-page":"S1021","article-title":"Multiple-dose pharmacokinetics and tolerance of lomefloxacin","volume":"2","author":"Mant","year":"1989","journal-title":"Rev Infect Dis"},{"key":"10.1378\/chest.98.6.1440_bib15","series-title":"PhD thesis","article-title":"The fluoroquinolones in the treatment of lower respiratory tract infections\/pharmacoldnetical, clinical and bacteriological aspects","author":"Wijnands","year":"1987"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216409499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216409499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T04:53:38Z","timestamp":1546491218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216409499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["S0012369216409499"],"URL":"https:\/\/doi.org\/10.1378\/chest.98.6.1440","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}