{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:27:43Z","timestamp":1790515663224,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1991,3]]},"DOI":"10.1378\/chest.99.3.538","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T18:28:23Z","timestamp":1194460103000},"page":"538-545","source":"Crossref","is-referenced-by-count":158,"title":["Radiation-Associated Valvular Disease*"],"prefix":"10.1016","volume":"99","author":[{"given":"Robert G.","family":"Carlson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Mayfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd","family":"Normann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.99.3.538_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0033-0620(84)90003-3","article-title":"Radiation-induced heart disease: an update","volume":"27","author":"Stewart","year":"1984","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1378\/chest.99.3.538_bib2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1148\/89.2.302","article-title":"Radiation-induced heart disease: a study of 25 patients","volume":"89","author":"Stewart","year":"1967","journal-title":"Radiology"},{"key":"10.1378\/chest.99.3.538_bib3","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/0002-9149(83)90209-6","article-title":"Cardiac disease after radiation therapy for Hodgkin's disease: analysis of 48 patients","volume":"51","author":"Applefeld","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.3.538_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00005792-197505000-00005","article-title":"Radiation-related pericardial effusions in patients with Hodgkin's disease","volume":"34","author":"Ruckdeschel","year":"1975","journal-title":"Medicine"},{"key":"10.1378\/chest.99.3.538_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0002-8703(69)90133-1","article-title":"Symptomatic constrictive pericarditis developing 45 years after radiation therapy to the mediastinum: as review of radiation pericarditis","volume":"77","author":"Haas","year":"1969","journal-title":"Am Heart J"},{"key":"10.1378\/chest.99.3.538_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1378\/chest.64.3.291","article-title":"Management of patients with radiation-induced pericarditis with effusion: a note on the development of aortic regurgitation in two of them","volume":"64","author":"Morton","year":"1973","journal-title":"Chest"},{"key":"10.1378\/chest.99.3.538_bib7","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/0002-9149(67)90458-4","article-title":"Effusive-constrictive radiation pericarditis: two cases illustrating value of angiocardiography in diagnosis","volume":"19","author":"Steinberg","year":"1967","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.3.538_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0735-1097(86)80120-6","article-title":"Radiation induced coronary artery disease","volume":"8","author":"Dunsmore","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.99.3.538_bib9","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/0002-9149(87)90345-6","article-title":"Clinical and angiographic features of coronary artery disease after chest irradiation","volume":"60","author":"McEniery","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.3.538_bib10","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1378\/chest.83.6.875","article-title":"Radiation-related chronic heart disease","volume":"83","author":"Totterman","year":"1983","journal-title":"Chest"},{"key":"10.1378\/chest.99.3.538_bib11","first-page":"1003","article-title":"Long-term cardiovascular evaluation of patients with Hodgkin's disease treated by thoracic mantle radiation therapy","volume":"66","author":"Applefeld","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"10.1378\/chest.99.3.538_bib12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0002-9343(81)90574-X","article-title":"Radiation heart disease: analysis of 16 young (aged 15 to 33 years) necrospy patients who received over 3,500 rads to the heart","volume":"70","author":"Brosius","year":"1981","journal-title":"Am J Med"},{"key":"10.1378\/chest.99.3.538_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0022-5223(19)38881-6","article-title":"Coronary artery disease following mediastinal radiation therapy","volume":"85","author":"Annest","year":"1983","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.99.3.538_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0002-9343(76)90531-3","article-title":"Coronary heart disease after mediastinal irradiation for Hodgkin's disease","volume":"60","author":"McReynolds","year":"1976","journal-title":"Am J Med"},{"key":"10.1378\/chest.99.3.538_bib15","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1378\/chest.71.5.664","article-title":"Bypass graft for coronary arterial stenosis following radiation therapy","volume":"71","author":"Iobal","year":"1977","journal-title":"Chest"},{"key":"10.1378\/chest.99.3.538_bib16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1378\/chest.71.5.563","article-title":"Radiation induced coronary artery disease","volume":"71","author":"Fajardo","year":"1977","journal-title":"Chest"},{"key":"10.1378\/chest.99.3.538_bib17","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archinte.1968.03640030022003","article-title":"Effects of radiation on the human heart: an electron microscopic study","volume":"121","author":"Burch","year":"1968","journal-title":"Arch Intern Med"},{"key":"10.1378\/chest.99.3.538_bib18","first-page":"244","article-title":"Pathogenesis of radiation-induced myocardial fibrosis","volume":"29","author":"Fajardo","year":"1973","journal-title":"Lab Invest"},{"key":"10.1378\/chest.99.3.538_bib19","first-page":"512","article-title":"Morphology of radiation-induced heart disease","volume":"86","author":"Fajardo","year":"1968","journal-title":"Arch Pathol Lab Med"},{"key":"10.1378\/chest.99.3.538_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0735-1097(83)80390-8","article-title":"Radiation-induced valvular dysfunction","volume":"2","author":"Warda","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.99.3.538_bib21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/0002-8703(84)90104-2","article-title":"Two-dimensional echocardiographic assessment of radiation-induced valvular heart disease","volume":"107","author":"Detrano","year":"1984","journal-title":"Am Heart J"},{"key":"10.1378\/chest.99.3.538_bib22","first-page":"1075","article-title":"Case Records of the Massachusetts General Hospital (case 17-1987)","volume":"316","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.99.3.538_bib23","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1200\/JCO.1988.6.10.1576","article-title":"Stage IA and IIA supra-diaphragmatic Hodgkin's disease: prognostic factors in surgically staged patients treated with mantle and paraaortic irradiation","volume":"6","author":"Mauch","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.3.538_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.7326\/0003-4819-109-3-183","article-title":"Intercurrent death after Hodgkin's disease therapy in radiotherapy and adjuvant MOPP trials","volume":"109","author":"Hancock","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.99.3.538_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/1097-0142(19870701)60:1<31::AID-CNCR2820600107>3.0.CO;2-D","article-title":"Late cardiac effects of mediastinal radiotherapy in patients with Hodgkin's disease","volume":"601","author":"Pohjola-Sintonen","year":"1987","journal-title":"Cancer"},{"key":"10.1378\/chest.99.3.538_bib26","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1200\/JCO.1985.3.4.546","article-title":"Echocardiographic abnormalities following cardiac radiation","volume":"3","author":"Perrault","year":"1985","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.3.538_bib27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/1097-0142(19870815)60:4<772::AID-CNCR2820600411>3.0.CO;2-A","article-title":"Cardiac disease after mediastinal irradiation for seminoma","volume":"60","author":"Lederman","year":"1987","journal-title":"Cancer"},{"key":"10.1378\/chest.99.3.538_bib28","first-page":"1283","article-title":"Pericardite constrictive et myocardite post-radiotherapique avec insuffisance mitrale","volume":"54","author":"Fouchard","year":"1978","journal-title":"Sem Hop Paris"},{"key":"10.1378\/chest.99.3.538_bib29","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0140-6736(81)92665-9","article-title":"Myocardial ischaemia, radiotherapy, and vinblastine","volume":"1","author":"Harris","year":"1981","journal-title":"Lancet"},{"key":"10.1378\/chest.99.3.538_bib30","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/1097-0142(197509)36:3<946::AID-CNCR2820360316>3.0.CO;2-5","article-title":"Radiation Adriamycin interactions: preliminary clinical observations","volume":"36","author":"Cassady","year":"1975","journal-title":"Cancer"},{"key":"10.1378\/chest.99.3.538_bib31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0368-1319(64)80043-0","article-title":"The synergism of X-irradiation and cholesterol-fat feeding on the development of coronary artery lesions","volume":"4","author":"Amromin","year":"1964","journal-title":"J Atheroscler Res"},{"key":"10.1378\/chest.99.3.538_bib32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1056\/NEJM198303103081005","article-title":"Late cardiac effects of therapeutic mediastinal irradiation: assessment by echocardiography and radionuclide angiography","volume":"308","author":"Gottdiener","year":"1983","journal-title":"N Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216309151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216309151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T23:23:26Z","timestamp":1588029806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216309151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,3]]}},"alternative-id":["S0012369216309151"],"URL":"https:\/\/doi.org\/10.1378\/chest.99.3.538","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1991,3]]}}}