{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:17:10Z","timestamp":1779895030016,"version":"3.53.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1991,5,1]],"date-time":"1991-05-01T00:00:00Z","timestamp":673056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1991,5,1]],"date-time":"1991-05-01T00:00:00Z","timestamp":673056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1991,5]]},"DOI":"10.1378\/chest.99.5.1066","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T13:28:23Z","timestamp":1194442103000},"page":"1066-1071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Echo\/Doppler and Hemodynamic Correlates of Vasodilator Responsiveness in Primary Pulmonary Hypertension"],"prefix":"10.1016","volume":"99","author":[{"given":"Susan B.","family":"Eysmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold I.","family":"Palevsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Reichek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Hackney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.99.5.1066_bib1","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1164\/ajrccm\/140.6.1623","article-title":"The acute administration of vasodilators in primary pulmonary hypertension","volume":"140","author":"Weir","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.99.5.1066_bib2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1161\/01.CIR.80.2.353","article-title":"Two-dimensional and Doppler echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension","volume":"80","author":"Eysmann","year":"1989","journal-title":"Circulation"},{"key":"10.1378\/chest.99.5.1066_bib3","first-page":"342","article-title":"The case for treatment of selected patients with primary pulmonary hypertension","volume":"134","author":"Reeves","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.99.5.1066_bib4","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.CIR.71.6.1191","article-title":"The effect of vasodilator therapy on the clinical outcome of patients with primary pulmonary hypertension","volume":"71","author":"Rich","year":"1985","journal-title":"Circulation"},{"key":"10.1378\/chest.99.5.1066_bib5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0735-1097(88)90421-4","article-title":"Evaluation of the responsiveness of elevated pulmonary vascular resistance in children by Doppler echocardiography","volume":"12","author":"Cooper","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.99.5.1066_bib6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","article-title":"Primary pulmonary hypertension: a national prospective study","volume":"107","author":"Rich","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.99.5.1066_bib7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/0002-9149(81)90152-1","article-title":"Two-dimensional echographic imaging of the left ventricle: comparison of mechanical and phased array systems in vitro","volume":"48","author":"Helak","year":"1981","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.5.1066_bib8","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0735-1097(85)80433-2","article-title":"An echocardiographic index for separation of right ventricular volume and pressure overload","volume":"5","author":"Ryan","year":"1985","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.99.5.1066_bib9","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0002-9149(85)90654-X","article-title":"Two-dimensional echocardiographic estimation of right ventricular area change and ejection fraction in infants with systemic right ventricle (transposition of the great arteries or hypoplastic left heart syndrome)","volume":"55","author":"Trowitzsch","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.5.1066_bib10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0002-9149(85)91177-4","article-title":"Echocardiographic ventricular shape analysis in congenital heart disease with right ventricular volume or pressure overload","volume":"56","author":"Azancot","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.5.1066_bib11","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0002-8703(84)90095-4","article-title":"Assessment of right ventricular function using two-dimensional echocardiography","volume":"107","author":"Kaul","year":"1984","journal-title":"Am Heart J"},{"key":"10.1378\/chest.99.5.1066_bib12","first-page":"91","author":"Grossman","year":"1980"},{"key":"10.1378\/chest.99.5.1066_bib13","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/01.CIR.80.5.1207","article-title":"Primary pulmonary hypertension, vascular structure, morphometry and responsiveness to vasodilator agents","volume":"80","author":"Palevsky","year":"1989","journal-title":"Circulation"},{"key":"10.1378\/chest.99.5.1066_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.me.36.020185.003023","article-title":"Vasodilator therapy for primary pulmonary hypertension","volume":"36","author":"Palevsky","year":"1985","journal-title":"Annu Rev Med"},{"issue":"4, pt 2","key":"10.1378\/chest.99.5.1066_bib15","first-page":"A350","article-title":"Comparison of acetylcholine and prostacyclin as screening agents for pulmonary vasodilator responsiveness in primary pulmonary hypertension","volume":"135","author":"Palevsky","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.99.5.1066_bib16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0002-9149(85)90319-4","article-title":"Magnitude and implications of spontaneous hemodynamic variability in primary pulmonary hypertension","volume":"55","author":"Rich","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.5.1066_bib17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0002-9149(88)90946-0","article-title":"Serial evaluation of left ventricular function in congestive heart failure by measurement of peak blood acceleration","volume":"61","author":"Sabbah","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.99.5.1066_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/01.CIR.67.2.377","article-title":"The use of Doppler flow velocity measurement to assess the hemodynamic response to vasodilators in patients with heart failure","volume":"67","author":"Elkayam","year":"1983","journal-title":"Circulation"},{"key":"10.1378\/chest.99.5.1066_bib19","first-page":"183","article-title":"Pharmacology of the pulmonary circulation","author":"Harris","year":"1986"},{"key":"10.1378\/chest.99.5.1066_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0002-9343(84)90279-1","article-title":"Characteristics of surviving and nonsurviving patients with primary pulmonary hypertension","volume":"76","author":"Rich","year":"1984","journal-title":"Am J Med"},{"key":"10.1378\/chest.99.5.1066_bib21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1378\/chest.91.5.675","article-title":"Primary pulmonary hypertension: length of survival in patients required for heart-lung transplantation","volume":"91","author":"Glanville","year":"1987","journal-title":"Chest"},{"key":"10.1378\/chest.99.5.1066_bib22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0033-0620(76)90021-9","article-title":"Afterload mismatch and preload reserve: a conceptual framework for the analysis of ventricular function","volume":"18","author":"Ross","year":"1976","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1378\/chest.99.5.1066_bib23","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0002-8703(83)90652-X","article-title":"Evaluation of dilated cardiomyopathy by pulsed Doppler echocardiography","volume":"106","author":"Gardin","year":"1983","journal-title":"Am Heart J"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216311369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216311369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:35:20Z","timestamp":1757921720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216311369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,5]]}},"alternative-id":["S0012369216311369"],"URL":"https:\/\/doi.org\/10.1378\/chest.99.5.1066","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1991,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Echo\/Doppler and Hemodynamic Correlates of Vasodilator Responsiveness in Primary Pulmonary Hypertension","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.99.5.1066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1991 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}