{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:04:10Z","timestamp":1790291050250,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1991,6]]},"DOI":"10.1378\/chest.99.6.1425","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T13:28:23Z","timestamp":1194442103000},"page":"1425-1432","source":"Crossref","is-referenced-by-count":71,"title":["Long-term Survival and Toxicity in Small Cell Lung Cancer"],"prefix":"10.1016","volume":"99","author":[{"given":"Kathy S.","family":"Albain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.99.6.1425_bib1","first-page":"278","article-title":"Therapy of small cell lung cancer: a perspective on two decades of clinical research","volume":"15","author":"Seifter","year":"1988","journal-title":"Semin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1200\/JCO.1990.8.3.396","article-title":"Ten-year survival of patients with smallcell lung cancer treated with combination chemotherapy with or without irradiation","volume":"8","author":"Johnson","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1200\/JCO.1990.8.1.48","article-title":"Neurologic, computed cranial tomographic, and magnetic resonance imaging abnormalities in patients with small-cell lung cancer: further follow-up of 6- to 10-year survivors","volume":"8","author":"Johnson","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1200\/JCO.1990.8.2.209","article-title":"Is prophylactic cranial irradiation indicated in small-cell lung cancer","volume":"8","author":"Fleck","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1200\/JCO.1990.8.2.215","article-title":"Late neurological complications after prophylactic cranial irradiation in patients with small-cell lung cancer: the Toronto experience","volume":"8","author":"Lishner","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib6","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1200\/JCO.1986.4.7.1044","article-title":"Dombernowsky P Mortality and morbidity in long-term surviving patients treated with chemotherapy with or without irradiation for small-cell lung cancer","volume":"4","author":"Osterlind","year":"1986","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7326\/0003-4819-88-2-194","article-title":"Small-cell carcinoma of the lung: combined chemotherapy and radiation: a Southwest Oncology Group study","volume":"88","author":"Livingston","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.99.6.1425_bib8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0002-9343(84)90095-0","article-title":"Long-term survival and toxicity in small cell lung cancer: a Southwest Oncology Group study","volume":"77","author":"Livingston","year":"1984","journal-title":"Am J Med"},{"key":"10.1378\/chest.99.6.1425_bib9","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1200\/JCO.1990.8.9.1563","article-title":"Determinants of improved outcome in small cell lung cancer: an analysis of the 2,580-patient Southwest Oncology Group Data base","volume":"8","author":"Albain","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib10","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1200\/JCO.1990.8.5.892","article-title":"Concurrent chemotherapy\/radiotherapy for limited small cell lung carcinoma","volume":"8","author":"McCracken","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib11","unstructured":"Taylor CW, Crowley JJ, Williamson SK, Miller TP, Taylor SA, Giri PGS, et al. Treatment of small cell lung cancer with an alternating regimen given at weekly intervals: a Southwest Oncology Group study. J Clin Oncol (in press)"},{"key":"10.1378\/chest.99.6.1425_bib12","series-title":"The analysis of binary data","author":"Cox","year":"1970"},{"key":"10.1378\/chest.99.6.1425_bib13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.7326\/0003-4819-106-5-655","article-title":"Chemotherapy alone or chemotherapy with chest radiation therapy in limited stage small cell lung cancer: a prospective, randomized trial","volume":"106","author":"Bunn","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.99.6.1425_bib14","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1056\/NEJM198704093161504","article-title":"Chemotherapy with or without radiation therapy in limited small-cell carcinoma of the lung","volume":"316","author":"Perry","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.99.6.1425_bib15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/1097-0142(19870101)59:1<6::AID-CNCR2820590106>3.0.CO;2-T","article-title":"Small cell carcinoma of the lung: a progress report of 15 years\u2019 experience","volume":"59","author":"Choi","year":"1987","journal-title":"Cancer"},{"key":"10.1378\/chest.99.6.1425_bib16","first-page":"4189","article-title":"Prognostic factors in small cell lung cancer: a multivariate model based on 778 patients treated with chemotherapy with or without irradiation","volume":"46","author":"Osterlind","year":"1986","journal-title":"Cancer Res"},{"key":"10.1378\/chest.99.6.1425_bib17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1200\/JCO.1989.7.3.344","article-title":"Prognostic factors in small-cell carcinoma of the lung: an analysis of 1,521 patients","volume":"7","author":"Spiegelman","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.7326\/0003-4819-107-4-451","article-title":"Superiority of alternating norcross resistant chemotherapy in extensive small cell lung cancer","volume":"107","author":"Evans","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.99.6.1425_bib19","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1200\/JCO.1988.6.7.1161","article-title":"Improvement of long-term survival in extensive small-cell lung cancer","volume":"7","author":"Jackson","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib20","doi-asserted-by":"crossref","first-page":"430","DOI":"10.7326\/0003-4819-103-3-430","article-title":"Patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation: data on potential cures, chronic toxicities, and late relapses after a 5- to 11-year follow-up","volume":"103","author":"Johnson","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.99.6.1425_bib21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1200\/JCO.1990.8.2.196","article-title":"Brain irradiation and systemic chemotherapy for small-cell lung cancer: dangerous liaisons? [editorial]","volume":"8","author":"Turrisi","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1378\/chest.99.6.1425_bib22","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0360-3016(88)90328-8","article-title":"Hobson's choice in the CNS radioprophylaxis of small cell lung cancer [editorial]","volume":"15","author":"Bleyer","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1378\/chest.99.6.1425_bib23","first-page":"500","article-title":"Prognostic implications of stage of disease and sites of metastases in patients with small cell carcinoma of the lung treated with intensive combination chemotherapy","volume":"123","author":"Ihde","year":"1981","journal-title":"Am Rev Respir Dis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216400966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216400966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T22:54:57Z","timestamp":1546469697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216400966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["S0012369216400966"],"URL":"https:\/\/doi.org\/10.1378\/chest.99.6.1425","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}