{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:29:00Z","timestamp":1764678540902,"version":"3.46.0"},"reference-count":0,"publisher":"EHU Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Dev. Biol."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>\n                    Tooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regulatory elements governing this process, Epiprofin\/Sp6 is a zinc finger transcription factor which is expressed in the embryonic dental epithelium and in differentiating pre-odontoblasts.\n                    <jats:italic>Epiprofin<\/jats:italic>\n                    knockout (\n                    <jats:italic>Epfn<\/jats:italic>\n                    -\/-) mice present severe dental abnormalities, such as supernumerary teeth and enamel hypoplasia. Here, we describe dentin defects in molars and incisors of\n                    <jats:italic>Epfn<\/jats:italic>\n                    -\/- mice. We observed that in the absence of Epfn, markers of early odontoblast differentiation, such as alkaline phosphatase activity,\n                    <jats:italic>Dsp\/Dpp<\/jats:italic>\n                    expression, and Collagen Type I deposition, are downregulated. In addition, the expression of tight and gap junction proteins was severely impaired in the predontoblastic cell layer of developing\n                    <jats:italic>Epfn<\/jats:italic>\n                    -\/- molars. Altogether, our data shows that Epfn is crucial for the proper differentiation of dental mesenchymal cells towards functional odontoblasts and subsequent dentin-matrix deposition.\n                  <\/jats:p>","DOI":"10.1387\/ijdb.240029lj","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:02:01Z","timestamp":1711544521000},"page":"19-24","source":"Crossref","is-referenced-by-count":1,"title":["Disrupted odontoblast differentiation and dentin dysplasia in\n                    <i>Epiprofin<\/i>\n                    -deficient mice"],"prefix":"10.1387","volume":"68","author":[{"given":"Lucia","family":"Jim\u00e9nez-Rojo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"de Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaskon","family":"Ibarretxe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando J.","family":"Unda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"352","container-title":["The International Journal of Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ijdb.ehu.eus\/article\/pdf\/240029lj","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ijdb.ehu.eus\/article\/pdf\/240029lj","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T10:22:07Z","timestamp":1736504527000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijdb.ehu.eus\/article\/240029lj"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"alternative-id":["240029lj"],"URL":"https:\/\/doi.org\/10.1387\/ijdb.240029lj","relation":{},"ISSN":["0214-6282","1696-3547"],"issn-type":[{"type":"print","value":"0214-6282"},{"type":"electronic","value":"1696-3547"}],"subject":[],"published":{"date-parts":[[2024]]}}}