{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:04:10Z","timestamp":1774724650514,"version":"3.50.1"},"reference-count":54,"publisher":"Veterinary World","issue":"5","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"am","delay-in-days":138,"URL":"http:\/\/veterinaryworld.org\/"},{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"tdm","delay-in-days":138,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet World"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Background and Aim: Fasciola hepatica and Fasciola gigantica are two commonly reported liver flukes that cause fascioliasis in ruminants. Among the members of the genus Fasciola, F. hepatica was identified in the study area. Fascioliasis is a major disease that affects the production of livestock by causing liver damage. F. hepatica has developed advanced mechanisms to trick, elude, and alter the host immune response, similar to an extrinsic stressor. These mechanisms consequently affect the animals' physiological and metabolic functions in vivo and postmortem changes, which have significant influences on animal welfare and meat quality development. Therefore, this study aimed to determine the current prevalence of cattle fascioliasis at abattoirs in El-Kharga city, New Valley Governorate, Egypt, and to investigate the changes in serum biochemical and immunological parameters and oxidative stress factors due to Fasciola spp. infection in terms of meat quality and immune response.\n\nMaterials and Methods: A total of 226 cattle were inspected for the presence of Fasciola spp. The liver of each cattle was examined by making several incisions for detecting adult Fasciola spp. in El- Kharga . The blood samples were collected to analyze the changes in serum biochemical and immunological parameters and oxidative stress factors.\n\nResults: Of the 226 cattle, 38 (16.81%) were positive for F. hepatica at the postmortem examination. Cattle infected with F. hepatica had highly elevated serum alanine aminotransferase, aspartate aminotransferase, glutamate dehydrogenase, \u03b3-glutamyl transferase, urea, and creatinine levels. Immunological cytokine profiles showed significantly increased serum interleukin (IL)-4, IL-10, and transforming growth factor-beta levels and a significantly decreased interferon-\u03b3 level. Furthermore, oxidative stress profiles showed significantly increased serum malondialdehyde and nitric oxide levels and significantly decreased total antioxidant capacity and reduced glutathione level.\n\nConclusion: This study demonstrated that F. hepatica infection alone is an oxidative stress factor that affects slaughtered animals, leading to biochemical and metabolic alterations in the early postmortem period.<\/jats:p>","DOI":"10.14202\/vetworld.2020.923-930","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T08:45:50Z","timestamp":1589791550000},"page":"923-930","source":"Crossref","is-referenced-by-count":10,"title":["Biochemical and immunological investigation of fascioliasis in cattle in Egypt"],"prefix":"10.14202","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-8601","authenticated-orcid":false,"given":"Nani","family":"Nasreldin","sequence":"first","affiliation":[{"name":"Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, New Valley University, El-Kharga, P.O. Box 72511, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-7475","authenticated-orcid":false,"given":"Rania Samir","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene, Faculty of Veterinary Medicine, New Valley University, El-Kharga, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5308","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Kowalczyk, S.J., Czopowicz M., Weber, C.N., M\u00fcller, E. and Kaba, J. (2018) Accuracy of a diagnostic model based on serum biochemical parameters in detecting cows at an increased risk of chronic fascioliasis. Vet. Parasitol., 254(2018): 15-20.","DOI":"10.1016\/j.vetpar.2018.02.038"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Zhang, F., Guo, A., Hou, J., Sun, M., Sheng, Z., Zhang, X., Huang, W., Elsheikha, H., and Zhu, X. 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