{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:58:00Z","timestamp":1782698280485,"version":"3.54.5"},"reference-count":55,"publisher":"Veterinary World","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet World"],"abstract":"<jats:p>Background and Aim: A significant cause of arsenic poisoning is polluted groundwater. Arsenic poisoning results in the suppression of spermatogenesis and the liver and kidneys are vulnerable to the toxic effects as well. Mucuna pruriens has been identified to have fertility-enhancing and anti-lipid peroxidation properties. Based on these properties of M. pruriens, this study aimed to investigate the efficacy of M. pruriens seed extract in reducing sodium arsenite-induced testicular impairment and hepato-renal histopathology in rats.\n\nMaterials and Methods: The study was divided into two groups; short-term (45 days) and long-term (90 days) treatment groups and each group was divided into nine subgroups. Subgroups 1 and 2 served as normal and N-acetyl cysteine (NAC) controls, respectively. Subgroups 3\u20139 received sodium arsenite in the drinking water (50 mg\/L). Subgroup-4 received NAC (210 mg\/kg body weight [BW]) orally once daily. Subgroups 5\u20137 received aqueous seed extract of M. pruriens (350, 530, and 700 mg\/kg BW, respectively) orally once daily. Subgroups 8 and 9 received a combination of NAC and aqueous seed extract (350 and 530 mg\/kg BW, respectively) orally once daily. Following the treatment, animals were sacrificed and sperm parameters and DNA damage were evaluated. Testis, liver, and kidneys were analyzed for histopathology.\n\nResults: Sodium arsenite-induced a significant reduction in sperm parameters and increase in the abnormal architecture of spermatozoa. Histology revealed tissue necrosis. The M. pruriens seed extract ameliorated the damaging effects of sodium arsenite with respect to tissue architecture and sperm parameters when coadministered.\n\nConclusion: Mucuna pruriens has beneficial effects against the deleterious effects of sodium arsenite on various tissues. Thus, M. pruriens (530 and 700 mg\/kg BW) supplementation would reduce the adverse changes observed with sodium arsenite exposure.<\/jats:p>","DOI":"10.14202\/vetworld.2023.82-93","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T11:26:53Z","timestamp":1673436413000},"page":"82-93","source":"Crossref","is-referenced-by-count":6,"title":["Ameliorating effect of Mucuna pruriens seed extract on sodium arsenite-induced testicular toxicity and hepato-renal histopathology in rats"],"prefix":"10.14202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7484-368X","authenticated-orcid":false,"given":"Preethi Lavina","family":"Concessao","sequence":"first","affiliation":[{"name":"Department of Physiology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-6946","authenticated-orcid":false,"given":"Kurady Laxminarayana","family":"Bairy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-7619","authenticated-orcid":false,"given":"Archana Parampalli","family":"Raghavendra","sequence":"additional","affiliation":[{"name":"Department of Physiology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5308","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Amitai, Y. and Koren, G. 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