{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:59:19Z","timestamp":1792065559053,"version":"4.4.0"},"reference-count":38,"publisher":"Veterinary World","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet World"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Background and Aim: Hepatobiliary disorders represent a significant clinical concern in canine medicine, contributing to substantial morbidity and mortality. However, comprehensive data on clinical presentation and hematological and biochemical alterations associated with these disorders in Vietnam remain limited. This study aimed to characterize the clinical manifestations and hematobiochemical profiles of dogs diagnosed with hepatobiliary disorders in Ho Chi Minh City, Vietnam.\n\nMaterials and Methods: Eighty client-owned dogs diagnosed with hepatobiliary disorders through histopathological confirmation were retrospectively evaluated. Clinical signs, age, breed, and sex were recorded. Hematological indices \u2013 including red and white blood cell counts, hemoglobin concentration, hematocrit, and platelet (PLT) count \u2013 and biochemical parameters \u2013 such as total protein (TP), albumin (ALB), globulin, bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), blood urea nitrogen (BUN), creatinine (CREA), and uric acid \u2013 were assessed. Data were analyzed using one-way analysis of variance and Pearson\u2019s Chi-square test, with statistical significance set at p &lt; 0.05.\n\nResults: Hepatitis was the most prevalent disorder (38.8%), followed by biliary disorders, hepatic lipidosis, neoplastic disorders (each 16.3%), and cirrhosis (12.5%). Vomiting (60.0%), jaundice (57.5%), and diarrhea (48.8%) were among the most frequent clinical signs, with significant variability across disorder types (p &lt; 0.05). A significant variation in PLT counts was observed, with the highest values in hepatic lipidosis cases (p = 0.04). Biochemical analysis revealed marked elevations in total bilirubin, ALT, AST, ALP, and GGT across disorders (p &lt; 0.05), particularly in hepatitis and neoplastic cases. Dogs with cirrhosis exhibited significantly reduced TP and ALB concentrations. Elevated BUN and CREA were also noted in dogs with neoplastic conditions, suggesting concurrent renal involvement.\n\nConclusion: This study is the first to delineate the clinical and hematobiochemical characteristics of canine hepatobiliary disorders in Vietnam. The findings underscore the diagnostic value of integrating clinical signs with laboratory indices, particularly elevated liver enzymes and hypoalbuminemia, in the identification and differentiation of hepatobiliary conditions. These insights may enhance clinical decision-making and contribute to improved diagnostic accuracy and therapeutic outcomes in veterinary hepatology.\n\nKeywords: biochemical analysis, canine hepatology, clinical signs, hematological profile, liver enzymes, Vietnam.<\/jats:p>","DOI":"10.14202\/vetworld.2025.986-993","type":"journal-article","created":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T03:45:20Z","timestamp":1745725520000},"page":"986-993","update-policy":"https:\/\/doi.org\/10.14202\/vetworld.2022.policies","source":"Crossref","is-referenced-by-count":3,"title":["Clinical features and hematological and biochemical blood parameters of dogs with hepatobiliary disorders"],"prefix":"10.14202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-1662","authenticated-orcid":false,"given":"Nguyen Vu Thuy Hong","family":"Loan","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Husbandry, HUTECH University, 475A Dien Bien Phu, Ward 25, Binh Thanh District, Ho Chi Minh City, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-7188","authenticated-orcid":false,"given":"Nguyen Van","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Animal Sciences and Veterinary Medicine, University of Agriculture and Forestry, Hue University, 102 Phung Hung Street, Hue City, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5646-2274","authenticated-orcid":false,"given":"Tran Thi","family":"Nhung","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Husbandry, HUTECH University, 475A Dien Bien Phu, Ward 25, Binh Thanh District, Ho Chi Minh City, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5308","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Nantasanti, A.S., Ongvisespaibool, T., Hakhen, B., Chuchalermporn, P., Maneesaay, P. and Thengchaisri, N. (2023) Predictive factors for two-year survival in dogs with hepatobiliary diseases: Importance of clinical and laboratory monitoring. Animals (Basel), 13(16): 2677.","DOI":"10.3390\/ani13162677"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Kumar, V., Kumar, A., Varshney, A.C., Tyagi, S.P., Kanwar, M.S. and Sharma, S.K. (2012) Diagnostic imaging of canine hepatobiliary affections: A review. Vet. Med. Int., 2012(1): 672107.","DOI":"10.1155\/2012\/672107"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Anglin, E.V., Lux, C.N., Sun, X., Folk, C.A. and Fazio, C. (2022) Clinical characteristics of, prognostic factors for, and long-term outcome of dogs with multiple acquired portosystemic shunts: 72 cases (2000\u20132018). J. Am. Vet. Med. 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