{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:42:55Z","timestamp":1785422575521,"version":"3.56.0"},"reference-count":71,"publisher":"Veterinary World","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["PG665"],"award-info":[{"award-number":["PG665"]}],"id":[{"id":"https:\/\/ror.org\/02xzytt36","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet World"],"published-print":{"date-parts":[[2026,3,31]]},"abstract":"<jats:p>Background and Aim: Cisplatin, a platinum-based chemotherapeutic agent, is widely employed in the treatment of various malignancies. However, its clinical utility is restricted by dose-limiting hepatorenal toxicities, primarily driven by oxidative stress, inflammation, and direct cytotoxicity. The present in vivo study was designed to evaluate the protective efficacy of Bacopa monnieri extract against cisplatin-induced hepatorenal toxicity in male Wistar rats, utilizing biochemical parameters, oxidative stress biomarkers, histopathological assessment, and the early renal injury marker Kidney Injury Molecule-1 (KIM-1).\n\nMaterials and Methods: Thirty male Wistar rats were randomly divided into five groups (n = 6 per group): control (normal saline), cisplatin (7.5 mg\/kg intraperitoneally on day 7), and three intervention groups receiving B. monnieri (BM) extract orally at 100, 200, or 300 mg\/kg daily for 10 consecutive days concomitantly with cisplatin. Urine samples were collected on day 9 for KIM-1 quantification. On day 11, animals were euthanized, and blood, liver, and kidney tissues were obtained for biochemical assays (liver and kidney function tests, malondialdehyde, glutathione, superoxide dismutase, catalase) and histopathological evaluation.\n\nResults: Administration of BM at 200 and 300 mg\/kg significantly attenuated cisplatin-induced elevations in serum alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase (all p &lt; 0.001 versus the cisplatin group). Total protein and albumin levels were restored toward control values in the 300 mg\/kg group. Urea concentrations decreased significantly at 300 mg\/kg, while creatinine levels were reduced at both 200 and 300 mg\/kg doses (p &lt; 0.001). Urinary KIM-1 concentrations remained elevated in all cisplatin-exposed groups without significant mitigation by BM. Dose-dependent improvements in antioxidant status were observed, with increased glutathione, superoxide dismutase, and catalase activities and decreased malondialdehyde levels in both liver and kidney tissues (p &lt; 0.001 at higher doses). These biochemical findings were strongly supported by histopathological evidence showing reduced inflammatory cell infiltration, tubular necrosis, hydropic degeneration, sinusoidal dilatation, and fatty change, with near-normal tissue architecture restored at the 300 mg\/kg dose.\n\nConclusion: BM extract confers significant, dose-dependent hepatorenal protection against cisplatin-induced toxicity, predominantly through its potent antioxidant mechanisms, with maximal efficacy at 300 mg\/kg. However, it failed to prevent early proximal tubular injury as reflected by persistent KIM-1 elevation. These results position BM as a promising adjunctive agent in cisplatin-based chemotherapy regimens and justify further mechanistic and clinical translational studies.\n\nKeywords: Bacopa monnieri, cisplatin hepatotoxicity, cisplatin nephrotoxicity, cisplatin-induced toxicity, hepatorenal protection, KIM-1 biomarker, oxidative stress, renal injury marker.<\/jats:p>","DOI":"10.14202\/vetworld.2026.1069-1084","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T05:56:16Z","timestamp":1774158976000},"page":"1069","update-policy":"https:\/\/doi.org\/10.14202\/vetworld.2022.policies","source":"Crossref","is-referenced-by-count":0,"title":["Protective effects of Bacopa monnieri against cisplatin-induced hepatorenal toxicity in rats: biochemical, oxidative stress, histopathological, and Kidney Injury Molecule-1\u2013based evidence"],"prefix":"10.14202","author":[{"given":"S.","family":"Sahana","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hg48t65","id-type":"ROR","asserted-by":"publisher"}],"name":"Kasturba Medical College, Manipal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-4024","authenticated-orcid":false,"given":"Shivaprakash","family":"Gangachannaiah","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hg48t65","id-type":"ROR","asserted-by":"publisher"}],"name":"Kasturba Medical College, Manipal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Maradi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hg48t65","id-type":"ROR","asserted-by":"publisher"}],"name":"Kasturba Medical College, Manipal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-0718","authenticated-orcid":false,"given":"K. G.","family":"Mohandas Rao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xzytt36","id-type":"ROR","asserted-by":"publisher"}],"name":"Manipal Academy of Higher Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangita G.","family":"Kamath","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hg48t65","id-type":"ROR","asserted-by":"publisher"}],"name":"Kasturba Medical College, Manipal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Adiga","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hg48t65","id-type":"ROR","asserted-by":"publisher"}],"name":"Kasturba Medical College, Manipal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chandana","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hg48t65","id-type":"ROR","asserted-by":"publisher"}],"name":"Kasturba Medical College, Manipal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monalisa","family":"Biswas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05hg48t65","id-type":"ROR","asserted-by":"publisher"}],"name":"Kasturba Medical College, Manipal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5308","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Li K, Li J, Li Z, Men L, Zuo H, Gong X. 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