{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T17:13:12Z","timestamp":1772903592682,"version":"3.50.1"},"reference-count":9,"publisher":"Korean Society of Clinical Oncology","issue":"2","content-domain":{"domain":["kjco.org"],"crossmark-restriction":true},"short-container-title":["Korean J Clin Oncol"],"abstract":"<jats:p>This study shows a case of neoadjuvant chemotherapy application for the management of a 34-year-old male patient diagnosed with invasive intraductal papillary mucinous neoplasm (IPMN), for which curative margin-negative resection initially seemed challenging. Five cycles of the FOLFIRINOX regimen (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) were administered preoperatively, resulting in a significant reduction of the intraductal mass size and deformity of the main vessels. The patient subsequently underwent a successful robotic pylorus-preserving pancreatoduodenectomy. Postoperatively, the patient received adjuvant chemotherapy with FOLFIRINOX, and after 5 months, showed no signs of tumor recurrence or specific complications. These findings suggest that neoadjuvant therapy can be a potentially effective strategy even in advanced invasive IPMN. Further research is necessary to establish guidelines for its application.<\/jats:p>","DOI":"10.14216\/kjco.23014","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T01:32:53Z","timestamp":1704418373000},"page":"80-83","update-policy":"https:\/\/doi.org\/10.14216\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Margin-negative minimally invasive pancreatoduodenectomy following FOLFIRINOX neoadjuvant chemotherapy in invasive intraductal papillary mucinous neoplasm of pancreas: a case report"],"prefix":"10.14216","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5111-9051","authenticated-orcid":true,"given":"Jinho","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4738-7670","authenticated-orcid":true,"given":"Seokjin","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5577-8201","authenticated-orcid":true,"given":"Eunsang","family":"Yim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-4039","authenticated-orcid":true,"given":"Su Hyeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-4658","authenticated-orcid":true,"given":"Chang Moo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5309","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.07.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2014.08.007"},{"key":"ref3","first-page":"1108","volume-title":"Patterns of recurrence after resection of IPMN: who, when, and how?","author":"Marchegiani","year":"2015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316027"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2022.05.897"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-019-01931-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6025-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.10.023"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00245"}],"container-title":["Korean Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/kjco.org\/upload\/pdf\/kjco-19-2-80.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:13:26Z","timestamp":1705281206000},"score":1,"resource":{"primary":{"URL":"http:\/\/kjco.org\/journal\/view.php?doi=10.14216\/kjco.23014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,31]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.14216\/kjco.23014","relation":{},"ISSN":["1738-8082","2288-4084"],"issn-type":[{"value":"1738-8082","type":"print"},{"value":"2288-4084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,31]]},"assertion":[{"value":"2023-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}