{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T09:06:35Z","timestamp":1767690395228,"version":"3.48.0"},"reference-count":30,"publisher":"Korean Society of Clinical Oncology","issue":"3","content-domain":{"domain":["www.kjco.org"],"crossmark-restriction":true},"short-container-title":["Korean J Clin Oncol"],"abstract":"<jats:p>Purpose: This systematic review and meta-analysis aimed to examine the relationship between ovarian and colorectal cancer, with a particular focus on the standardized incidence ratio (SIR).Methods: A comprehensive search was conducted across multiple databases, including Scopus, Web of Science, PubMed, and Google Scholar. A total of 20 studies were included in the final analysis.Results: The results indicated that women with ovarian cancer had a significantly higher incidence of colorectal cancer (SIR, 1.69; 95% confidence interval [CI], 1.39\u20131.98), with an increased risk for both colon (SIR, 1.57; 95% CI, 1.14\u20131.99) and rectal cancers (SIR, 1.58; 95% CI, 1.38\u20131.78). Subgroup analysis of borderline ovarian tumor revealed an SIR for colorectal cancer of 1.27 (95% CI, 0.99\u20131.55), with a significant risk in the serous subtype (SIR, 1.38; 95% CI, 1.09\u20131.67). Conversely, studies examining ovarian cancer in women diagnosed with colorectal cancer showed an SIR of 1.48 (95% CI, 1.17\u20131.79). Specifically, women with colon cancer had a higher incidence of ovarian cancer (SIR, 1.64; 95% CI, 1.25\u20132.03), while women with rectal cancer showed a decreased risk (SIR, 0.88; 95% CI, 0.77\u20130.99). The results underscore the potential bidirectional relationship between ovarian and colorectal cancers, which may be influenced by genetic predispositions.Conclusion: Future advanced genetic studies are needed to better understand the underlying molecular mechanisms. Additionally, the results emphasize the importance of careful cancer surveillance and early detection strategies for women with a history of either ovarian cancer or colorectal cancer.<\/jats:p>","DOI":"10.14216\/kjco.25355","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:14:36Z","timestamp":1766128476000},"page":"150-158","update-policy":"https:\/\/doi.org\/10.14216\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between ovarian and colorectal cancers: a systematic review and meta-analysis"],"prefix":"10.14216","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-2509","authenticated-orcid":true,"given":"Heba","family":"Ramadan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5309","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref1","first-page":"287","volume-title":"Ovarian cancer in the world: epidemiology 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