{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:24:01Z","timestamp":1792513441392,"version":"4.5.0"},"reference-count":122,"publisher":"Xia & He Publishing","issue":"X","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,28]]},"DOI":"10.14218\/jcth.2019.00051","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T22:06:11Z","timestamp":1578002771000},"page":"1-11","source":"Crossref","is-referenced-by-count":59,"title":["Non-alcoholic Fatty Liver Disease: Growing Burden, Adverse Outcomes and Associations"],"prefix":"10.14218","volume":"X","author":[{"given":"Ramesh","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev Nayan","family":"Priyadarshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utpal","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5334","published-online":{"date-parts":[[2019,12,29]]},"reference":[{"key":"key20200102220606_b1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/cld.81","article-title":"Nonalcoholic fatty liver disease: Definitions, risk factors, and workup","volume":"1","author":"Puri","year":"2012","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"key20200102220606_b2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic","volume":"10","author":"Loomba","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key20200102220606_b3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","article-title":"Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults","volume":"34","author":"Vernon","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"key20200102220606_b4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrgastro.2013.34","article-title":"NAFLD in Asia--as common and important as in the West","volume":"10","author":"Farrell","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key20200102220606_b5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"key20200102220606_b6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/jgh.12428","article-title":"Prevalence of nonalcoholic fatty liver disease in mainland of China: a meta-analysis of published studies","volume":"29","author":"Li","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200102220606_b7","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00535-003-1178-8","article-title":"Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background","volume":"38","author":"Kojima","year":"2003","journal-title":"J Gastroenterol"},{"key":"key20200102220606_b8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cld.2017.08.010","article-title":"Nonalcoholic fatty liver disease and metabolic syndrome","volume":"22","author":"Kim","year":"2018","journal-title":"Clin Liver Dis"},{"issue":"Suppl 2","key":"key20200102220606_b9","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s12072-013-9455-y","article-title":"Hard clinical outcomes in patients with NAFLD","volume":"7","author":"Kumar","year":"2013","journal-title":"Hepatol Int"},{"key":"key20200102220606_b10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11901-016-0295-9","article-title":"Extrahepatic manifestations of nonalcoholic fatty liver disease","volume":"15","author":"VanWagner","year":"2016","journal-title":"Curr Hepatol Rep"},{"key":"key20200102220606_b11","doi-asserted-by":"crossref","first-page":"e0142278","DOI":"10.1371\/journal.pone.0142278","article-title":"Influence of fatty liver on the severity and clinical outcome in acute pancreatitis","volume":"10","author":"Xu","year":"2015","journal-title":"PLoS One"},{"key":"key20200102220606_b12","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.18632\/oncotarget.22755","article-title":"Increased risk of cerebrovascular accident related to non-alcoholic fatty liver disease: a meta-analysis","volume":"9","author":"Hu","year":"2017","journal-title":"Oncotarget"},{"key":"key20200102220606_b13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2147\/DMSO.S192256","article-title":"Relationship between nonalcoholic fatty liver disease and bone mineral density in adolescents with obesity: a meta-analysis","volume":"12","author":"Sun","year":"2019","journal-title":"Diabetes Metab Syndr Obes"},{"key":"key20200102220606_b14","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.26986","article-title":"Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S","volume":"59","author":"Wong","year":"2014","journal-title":"Hepatology"},{"key":"key20200102220606_b15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","article-title":"Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States","volume":"148","author":"Wong","year":"2015","journal-title":"Gastroenterology"},{"key":"key20200102220606_b16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cgh.2011.03.020","article-title":"Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008","volume":"9","author":"Younossi","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key20200102220606_b17","doi-asserted-by":"crossref","first-page":"e027244","DOI":"10.1136\/bmjopen-2018-027244","article-title":"Cohort profile: the Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort","volume":"9","author":"Chalmers","year":"2019","journal-title":"BMJ Open"},{"key":"key20200102220606_b18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"key20200102220606_b19","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7150\/ijbs.29599","article-title":"Obesity, nonalcoholic fatty liver disease and adipocytokines network in promotion of cancer","volume":"15","author":"Divella","year":"2019","journal-title":"Int J Biol Sci"},{"key":"key20200102220606_b20","doi-asserted-by":"crossref","first-page":"e8179","DOI":"10.1097\/MD.0000000000008179","article-title":"Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: A meta-analysis","volume":"96","author":"Dai","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"key20200102220606_b21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/obr.12407","article-title":"Obesity is an independent risk factor for non-alcoholic fatty liver disease: evidence from a meta-analysis of 21 cohort studies","volume":"17","author":"Li","year":"2016","journal-title":"Obes Rev"},{"key":"key20200102220606_b22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"key20200102220606_b23","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.metabol.2016.01.001","article-title":"Non-alcoholic fatty liver disease and diabetes","volume":"65","author":"Hazlehurst","year":"2016","journal-title":"Metabolism"},{"key":"key20200102220606_b24","first-page":"216","article-title":"Non-alcoholic fatty liver disease in lean subjects: Characteristics and implications","volume":"5","author":"Kumar","year":"2017","journal-title":"J Clin Transl Hepatol"},{"key":"key20200102220606_b25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3350\/cmh.2016.0109","article-title":"Genetic predisposition in nonalcoholic fatty liver disease","volume":"23","author":"Sookoian","year":"2017","journal-title":"Clin Mol Hepatol"},{"key":"key20200102220606_b26","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/hep.1840220616","article-title":"The natural history of nonalcoholic fatty liver: a follow-up study","volume":"22","author":"Teli","year":"1995","journal-title":"Hepatology"},{"key":"key20200102220606_b27","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/gut.2009.205088","article-title":"Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years","volume":"59","author":"Wong","year":"2010","journal-title":"Gut"},{"key":"key20200102220606_b28","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jhep.2014.11.034","article-title":"Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management","volume":"62","author":"McPherson","year":"2015","journal-title":"J Hepatol"},{"key":"key20200102220606_b29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cgh.2014.04.014","article-title":"Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies","volume":"13","author":"Singh","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key20200102220606_b30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jhep.2009.03.019","article-title":"Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis","volume":"51","author":"Argo","year":"2009","journal-title":"J Hepatol"},{"key":"key20200102220606_b31","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1111\/j.1572-0241.2003.07659.x","article-title":"The natural history of nonalcoholic fatty liver disease: a clinical histopathological study","volume":"98","author":"Harrison","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"key20200102220606_b32","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jhep.2004.07.010","article-title":"Silent non-alcoholic fatty liver disease-a clinical-histological study","volume":"41","author":"Sorrentino","year":"2004","journal-title":"J Hepatol"},{"key":"key20200102220606_b33","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1016\/S0618-8278(19)30562-6","article-title":"THU-299-Increased risk of mortality with liver disease progression in non-alcoholic fatty liver disease\/non-alcoholic steatohepatitis patients: An analysis of French national hospital care","volume":"70","author":"Boursier","year":"2019","journal-title":"J Hepatol"},{"key":"key20200102220606_b34","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/hep.1840110114","article-title":"The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years","volume":"11","author":"Powell","year":"1990","journal-title":"Hepatology"},{"key":"key20200102220606_b35","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1053\/hupa.2002.129419","article-title":"Cryptogenic cirrhosis: clinicopathologic findings at and after liver transplantation","volume":"33","author":"Ayata","year":"2002","journal-title":"Hum Pathol"},{"key":"key20200102220606_b36","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1097\/MEG.0b013e32835643f1","article-title":"Etiologic types of end-stage chronic liver disease in adults: analysis of prevalence and their temporal changes from a study on native liver explants","volume":"24","author":"Nayak","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"key20200102220606_b37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/gast.2002.34168","article-title":"Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma","volume":"123","author":"Bugianesi","year":"2002","journal-title":"Gastroenterology"},{"key":"key20200102220606_b38","first-page":"2101","article-title":"Prognosis of patients with a diagnosis of fatty liver\u2014a registry-based cohort study","volume":"50","author":"Jepsen","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"key20200102220606_b39","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.humpath.2009.06.021","article-title":"End-stage nonalcoholic fatty liver disease: evaluation of pathomorphologic features and relationship to cryptogenic cirrhosis from study of explant livers in a living donor liver transplant program","volume":"41","author":"Nayak","year":"2010","journal-title":"Hum Pathol"},{"key":"key20200102220606_b40","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5306\/wjco.v8.i6.429","article-title":"Epidemic of non-alcoholic fatty liver disease and hepatocellular carcinoma","volume":"8","author":"Said","year":"2017","journal-title":"World J Clin Oncol"},{"key":"key20200102220606_b41","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/hep.22734","article-title":"Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis","volume":"49","author":"Paradis","year":"2009","journal-title":"Hepatology"},{"key":"key20200102220606_b42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/hep.28368","article-title":"Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study","volume":"63","author":"Piscaglia","year":"2016","journal-title":"Hepatology"},{"key":"key20200102220606_b43","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/s00535-009-0112-0","article-title":"Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis","volume":"44","author":"Kawada","year":"2009","journal-title":"J Gastroenterol"},{"key":"key20200102220606_b44","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3748\/wjg.v16.i12.1436","article-title":"Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: our case series and literature review","volume":"16","author":"Takuma","year":"2010","journal-title":"World J Gastroenterol"},{"key":"key20200102220606_b45","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/hep.28123","article-title":"Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009","volume":"62","author":"Younossi","year":"2015","journal-title":"Hepatology"},{"key":"key20200102220606_b46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2013.08.011","article-title":"Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team","volume":"60","author":"Dyson","year":"2014","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"key20200102220606_b47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000333210","article-title":"Relative etiological role of prior hepatitis B virus infection and nonalcoholic fatty liver disease in the development of non-B non-C hepatocellular carcinoma in a hepatitis B-endemic area","volume":"84","author":"Cho","year":"2011","journal-title":"Digestion"},{"key":"key20200102220606_b48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jgh3.12070","article-title":"Epidemiology of non-alcoholic fatty liver disease-related hepatocellular carcinoma and its implications","volume":"2","author":"Wong","year":"2018","journal-title":"JGH Open"},{"key":"key20200102220606_b49","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12885-015-1197-x","article-title":"Treatment and survival of non-alcoholic steatohepatitis associated hepatocellular carcinoma","volume":"15","author":"Weinmann","year":"2015","journal-title":"BMC Cancer"},{"key":"key20200102220606_b50","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"},{"key":"key20200102220606_b51","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jhep.2008.06.018","article-title":"Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease","volume":"49","author":"Ong","year":"2008","journal-title":"J Hepatol"},{"key":"key20200102220606_b52","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/hep.23314","article-title":"Decreased survival of subjects with elevated liver function tests during a 28-year follow-up","volume":"51","author":"S\u00f6derberg","year":"2010","journal-title":"Hepatology"},{"key":"key20200102220606_b53","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/hep.27368","article-title":"Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up","volume":"61","author":"Ekstedt","year":"2015","journal-title":"Hepatology"},{"key":"key20200102220606_b54","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/07853890.2010.518623","article-title":"Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity","volume":"43","author":"Musso","year":"2011","journal-title":"Ann Med"},{"key":"key20200102220606_b55","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1751-2980.2011.00571.x","article-title":"Natural course of nonalcoholic fatty liver disease in southern China: a prospective cohort study","volume":"13","author":"Zhou","year":"2012","journal-title":"J Dig Dis"},{"key":"key20200102220606_b56","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/hep.26156","article-title":"Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States","volume":"57","author":"Kim","year":"2013","journal-title":"Hepatology"},{"key":"key20200102220606_b57","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/hep.29085","article-title":"Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis","volume":"65","author":"Dulai","year":"2017","journal-title":"Hepatology"},{"key":"key20200102220606_b58","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.21327","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes","volume":"44","author":"Ekstedt","year":"2006","journal-title":"Hepatology"},{"key":"key20200102220606_b59","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2337\/dc08-1870","article-title":"Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women\u2019s Heart and Health Study and meta-analysis","volume":"32","author":"Fraser","year":"2009","journal-title":"Diabetes Care"},{"key":"key20200102220606_b60","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/hep.24268","article-title":"Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality","volume":"53","author":"Younossi","year":"2011","journal-title":"Hepatology"},{"key":"key20200102220606_b61","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrendo.2017.173","article-title":"Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus","volume":"14","author":"Targher","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"key20200102220606_b62","doi-asserted-by":"crossref","first-page":"H1298","DOI":"10.1152\/ajpheart.00306.2014","article-title":"Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease","volume":"307","author":"Pugh","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20200102220606_b63","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.atherosclerosis.2008.09.012","article-title":"Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome","volume":"204","author":"Kim","year":"2009","journal-title":"Atherosclerosis"},{"key":"key20200102220606_b64","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s10620-011-1819-3","article-title":"The relationship between arterial stiffness and nonalcoholic fatty liver disease","volume":"57","author":"Lee","year":"2012","journal-title":"Dig Dis Sci"},{"key":"key20200102220606_b65","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/hep.25593","article-title":"Nonalcoholic fatty liver disease is associated with coronary artery calcification","volume":"56","author":"Kim","year":"2012","journal-title":"Hepatology"},{"key":"key20200102220606_b66","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jhep.2008.06.012","article-title":"Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review","volume":"49","author":"Sookoian","year":"2008","journal-title":"J Hepatol"},{"key":"key20200102220606_b67","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.atherosclerosis.2013.07.052","article-title":"A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care?","volume":"230","author":"Oni","year":"2013","journal-title":"Atherosclerosis"},{"key":"key20200102220606_b68","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/j.gastro.2016.06.001","article-title":"Persistent nonalcoholic fatty liver disease increases risk for carotid atherosclerosis","volume":"151","author":"Sinn","year":"2016","journal-title":"Gastroenterology"},{"key":"key20200102220606_b69","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1517\/14656566.2014.876992","article-title":"New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease","volume":"15","author":"Sahebkar","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"key20200102220606_b70","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MEG.0000000000000008","article-title":"Impaired left ventricular mechanics in nonalcoholic fatty liver disease: a speckle-tracking echocardiography study","volume":"26","author":"Karabay","year":"2014","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"key20200102220606_b71","first-page":"457","article-title":"Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fatty liver disease","volume":"17","author":"Fotbolcu","year":"2010","journal-title":"Cardiol J"},{"key":"key20200102220606_b72","doi-asserted-by":"crossref","first-page":"e0142937","DOI":"10.1371\/journal.pone.0142937","article-title":"Non-alcoholic fatty liver disease as a predictor of atrial fibrillation in middle-aged population (OPERA study)","volume":"10","author":"K\u00e4r\u00e4j\u00e4m\u00e4ki","year":"2015","journal-title":"PLoS One"},{"key":"key20200102220606_b73","doi-asserted-by":"crossref","first-page":"e001820","DOI":"10.1161\/JAHA.115.001820","article-title":"Nonalcoholic fatty liver disease is associated with QT prolongation in the general population","volume":"4","author":"Hung","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"key20200102220606_b74","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.amjmed.2003.07.014","article-title":"The association between the length of the QT interval and mortality in the Cardiovascular Health Study","volume":"115","author":"Robbins","year":"2003","journal-title":"Am J Med"},{"key":"key20200102220606_b75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/hep.26510","article-title":"Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"59","author":"Verrijken","year":"2014","journal-title":"Hepatology"},{"key":"key20200102220606_b76","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/hep.28253","article-title":"Long-term clinical outcomes after fatty liver screening in patients undergoing coronary angiogram: A prospective cohort study","volume":"63","author":"Wong","year":"2016","journal-title":"Hepatology"},{"key":"key20200102220606_b77","doi-asserted-by":"crossref","first-page":"33386","DOI":"10.1038\/srep33386","article-title":"Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"key":"key20200102220606_b78","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2016.05.013","article-title":"Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis","volume":"65","author":"Targher","year":"2016","journal-title":"J Hepatol"},{"key":"key20200102220606_b79","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jhep.2019.08.018","article-title":"The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity - A longitudinal cohort study","volume":"71","author":"Allen","year":"2019","journal-title":"J Hepatol"},{"key":"key20200102220606_b80","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1440-1746.2011.06816.x","article-title":"Colorectal neoplasms in relation to non-alcoholic fatty liver disease in Korean women: a retrospective cohort study","volume":"27","author":"Lee","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200102220606_b81","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gut.2011.237974","article-title":"High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis","volume":"60","author":"Wong","year":"2011","journal-title":"Gut"},{"key":"key20200102220606_b82","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/codi.12172","article-title":"Patients with nonalcoholic fatty liver disease have higher risk of colorectal adenoma after negative baseline colonoscopy","volume":"15","author":"Huang","year":"2013","journal-title":"Colorectal Dis"},{"key":"key20200102220606_b83","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12032-007-0034-8","article-title":"A case-control study of non-alcoholic fatty liver disease in breast cancer","volume":"24","author":"Bilici","year":"2007","journal-title":"Med Oncol"},{"key":"key20200102220606_b84","doi-asserted-by":"crossref","first-page":"e1001680","DOI":"10.1371\/journal.pmed.1001680","article-title":"Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis","volume":"11","author":"Musso","year":"2014","journal-title":"PLoS Med"},{"key":"key20200102220606_b85","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/j.ajkd.2014.05.019","article-title":"CKD and nonalcoholic fatty liver disease","volume":"64","author":"Targher","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"key20200102220606_b86","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/TP.0000000000000048","article-title":"Evolving frequency and outcomes of simultaneous liver kidney transplants based on liver disease etiology","volume":"98","author":"Singal","year":"2014","journal-title":"Transplantation"},{"key":"key20200102220606_b87","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molmed.2015.08.005","article-title":"Emerging liver-kidney interactions in nonalcoholic fatty liver disease","volume":"21","author":"Musso","year":"2015","journal-title":"Trends Mol Med"},{"key":"key20200102220606_b88","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12020-015-0640-8","article-title":"Evidence that non-alcoholic fatty liver disease and polycystic ovary syndrome are associated by necessity rather than chance: a novel hepato-ovarian axis?","volume":"51","author":"Targher","year":"2016","journal-title":"Endocrine"},{"key":"key20200102220606_b89","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s40618-017-0708-9","article-title":"Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: systematic review and meta-analysis","volume":"40","author":"Rocha","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"key20200102220606_b90","doi-asserted-by":"crossref","first-page":"14172","DOI":"10.3748\/wjg.v20.i39.14172","article-title":"Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome","volume":"20","author":"Kelley","year":"2014","journal-title":"World J Gastroenterol"},{"key":"key20200102220606_b91","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"key20200102220606_b92","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1164\/rccm.201806-1109TR","article-title":"Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease","volume":"199","author":"Mesarwi","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200102220606_b93","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jhep.2011.04.022","article-title":"Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese","volume":"56","author":"Aron-Wisnewsky","year":"2012","journal-title":"J Hepatol"},{"key":"key20200102220606_b94","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1378\/chest.13-0938","article-title":"Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea","volume":"145","author":"Minville","year":"2014","journal-title":"Chest"},{"key":"key20200102220606_b95","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jaad.2013.10.044","article-title":"Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years old or older: Results from a population-based study","volume":"70","author":"van der Voort","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"key20200102220606_b96","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jhep.2009.06.008","article-title":"Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis","volume":"51","author":"Miele","year":"2009","journal-title":"J Hepatol"},{"key":"key20200102220606_b97","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jhep.2009.04.020","article-title":"Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis","volume":"51","author":"Gisondi","year":"2009","journal-title":"J Hepatol"},{"key":"key20200102220606_b98","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s40618-015-0315-6","article-title":"Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?","volume":"38","author":"Targher","year":"2015","journal-title":"J Endocrinol Invest"},{"key":"key20200102220606_b99","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1210\/jc.2011-3010","article-title":"Association between nonalcoholic fatty liver disease (NAFLD) and osteoporotic fracture in middle-aged and elderly Chinese","volume":"97","author":"Li","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key20200102220606_b100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jhep.2016.08.019","article-title":"Sarcopenia is an independent risk factor for non-alcoholic steatohepatitis and significant fibrosis","volume":"66","author":"Koo","year":"2017","journal-title":"J Hepatol"},{"key":"key20200102220606_b101","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/hep.30049","article-title":"Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: A 7-year longitudinal study","volume":"68","author":"Kim","year":"2018","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"key20200102220606_b102","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.1016\/j.dsx.2016.12.033","article-title":"Nonalcoholic fatty liver disease and the risk of clinical cardiovascular events: A systematic review and meta-analysis","volume":"11","author":"Mahfood Haddad","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"key20200102220606_b103","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.amsu.2018.08.012","article-title":"Post hepatectomy liver failure - A comprehensive review of current concepts and controversies","volume":"34","author":"Ray","year":"2018","journal-title":"Ann Med Surg (Lond)"},{"key":"key20200102220606_b104","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1091-255X(98)80025-5","article-title":"Hepatic steatosis as a potential risk factor for major hepatic resection","volume":"2","author":"Behrns","year":"1998","journal-title":"J Gastrointest Surg"},{"key":"key20200102220606_b105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S1072-7515(00)00261-1","article-title":"Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection","volume":"191","author":"Belghiti","year":"2000","journal-title":"J Am Coll Surg"},{"key":"key20200102220606_b106","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","article-title":"Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases","volume":"24","author":"Vauthey","year":"2006","journal-title":"J Clin Oncol"},{"key":"key20200102220606_b107","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/TP.0000000000002466","article-title":"Steatosis in liver transplantation: Current limitations and future strategies","volume":"103","author":"Linares","year":"2019","journal-title":"Transplantation"},{"key":"key20200102220606_b108","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1097\/00007890-199611150-00011","article-title":"Use of fatty donor liver is associated with diminished early patient and graft survival","volume":"62","author":"Marsman","year":"1996","journal-title":"Transplantation"},{"key":"key20200102220606_b109","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/lt.21943","article-title":"Recurrent disease following liver transplantation for nonalcoholic steatohepatitis cirrhosis","volume":"15","author":"Malik","year":"2009","journal-title":"Liver Transpl"},{"key":"key20200102220606_b110","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/lt.22004","article-title":"Nonalcoholic fatty liver disease after liver transplantation for cryptogenic cirrhosis or nonalcoholic fatty liver disease","volume":"16","author":"Yalamanchili","year":"2010","journal-title":"Liver Transpl"},{"key":"key20200102220606_b111","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MEG.0b013e32832fcdf0","article-title":"Prevalence and factors associated with the presence of nonalcoholic fatty liver disease in an adult population in Spain","volume":"22","author":"Caballer\u00eda","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"key20200102220606_b112","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/07853890.2014.966752","article-title":"Prevalence and determinants of fatty liver in normal-weight and overweight young adults. The Cardiovascular Risk in Young Finns Study","volume":"47","author":"Suomela","year":"2015","journal-title":"Ann Med"},{"key":"key20200102220606_b113","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/ajg.2013.70","article-title":"Relationship of non-alcoholic fatty liver disease with cholecystectomy in the US population","volume":"108","author":"Ruhl","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"key20200102220606_b114","first-page":"501","article-title":"Relationship between obesity, metabolic syndrome, and nonalcoholic fatty liver disease in the elderly agricultural and fishing population of Taiwan","volume":"9","author":"Shen","year":"2014","journal-title":"Clin Interv Aging"},{"key":"key20200102220606_b115","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.metabol.2012.08.005","article-title":"In patients with non-alcoholic fatty liver disease, metabolically abnormal individuals are at a higher risk for mortality while metabolically normal individuals are not","volume":"62","author":"Younossi","year":"2013","journal-title":"Metabolism"},{"key":"key20200102220606_b116","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/ajg.2013.349","article-title":"Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population","volume":"108","author":"Chang","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"key20200102220606_b117","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1590\/S0004-27302013000800006","article-title":"Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China","volume":"57","author":"Cai","year":"2013","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"key20200102220606_b118","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/j.1440-1746.2009.05831.x","article-title":"Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population","volume":"24","author":"Dassanayake","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200102220606_b119","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","article-title":"The natural history of nonalcoholic fatty liver disease: a population-based cohort study","volume":"129","author":"Adams","year":"2005","journal-title":"Gastroenterology"},{"key":"key20200102220606_b120","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/hep.23135","article-title":"Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels","volume":"50","author":"Haring","year":"2009","journal-title":"Hepatology"},{"key":"key20200102220606_b121","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cgh.2008.11.005","article-title":"Long-term follow-up of patients with nonalcoholic fatty liver","volume":"7","author":"Rafiq","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key20200102220606_b122","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.jacc.2016.01.070","article-title":"Nonalcoholic fatty liver disease and incident cardiac events: The multi-ethnic study of atherosclerosis","volume":"67","author":"Zeb","year":"2016","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Clinical and Translational Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.xiahepublishing.com\/2310-8819\/ArticleFullText.aspx?sid=2&id=10.14218%2fJCTH.2019.00051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:17:45Z","timestamp":1783707465000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.xiahepublishing.com\/2310-8819\/ArticleFullText.aspx?sid=2&id=10.14218%2fJCTH.2019.00051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,28]]},"references-count":122,"journal-issue":{"issue":"X","published-online":{"date-parts":[[2019,12,29]]},"published-print":{"date-parts":[[2019,12,28]]}},"alternative-id":["10.14218\/JCTH.2019.00051"],"URL":"https:\/\/doi.org\/10.14218\/jcth.2019.00051","relation":{},"ISSN":["2225-0719","2310-8819"],"issn-type":[{"value":"2225-0719","type":"print"},{"value":"2310-8819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,28]]}}}