{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:14:11Z","timestamp":1783710851150,"version":"3.55.0"},"reference-count":114,"publisher":"Xia & He Publishing","issue":"000","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,25]]},"DOI":"10.14218\/jcth.2021.00062","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T22:26:25Z","timestamp":1619475985000},"page":"000-000","source":"Crossref","is-referenced-by-count":11,"title":["HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site"],"prefix":"10.14218","volume":"000","author":[{"given":"Dake","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urlike","family":"Protzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5334","published-online":{"date-parts":[[2021,4,25]]},"reference":[{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.21037\/jgo.2017.03.14","article-title":"Viral hepatitis and hepatocellular carcinoma: etiology and management","volume":"8","author":"Zamor","year":"2017","journal-title":"J Gastrointest Oncol"},{"issue":"5772","key":"key20210426222612_JCTH-D-21-00062-b2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/286533a0","article-title":"Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma","volume":"286","author":"Brechot","year":"1980","journal-title":"Nature"},{"issue":"5772","key":"key20210426222612_JCTH-D-21-00062-b3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/286535a0","article-title":"Integration of hepatitis B virus sequences and their expression in a human hepatoma cell","volume":"286","author":"Edman","year":"1980","journal-title":"Nature"},{"issue":"9","key":"key20210426222612_JCTH-D-21-00062-b4","doi-asserted-by":"crossref","first-page":"e40363","DOI":"10.1371\/journal.pone.0040363","article-title":"Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis","volume":"7","author":"Jiang","year":"2012","journal-title":"PLoS One"},{"issue":"4 Pt 1","key":"key20210426222612_JCTH-D-21-00062-b5","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/hep.1840120410","article-title":"HBV-DNA sequences in tumor and nontumor tissue in a patient with the fibrolamellar variant of hepatocellular carcinoma","volume":"12","author":"Davison","year":"1990","journal-title":"Hepatology"},{"issue":"3","key":"key20210426222612_JCTH-D-21-00062-b6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/jcb.240200310","article-title":"Integration of HBV-DNA into liver and hepatocellular carcinoma cells during persistent HBV infection","volume":"20","author":"Shafritz","year":"1982","journal-title":"J Cell Biochem"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1053\/j.gastro.2018.07.057","article-title":"Development of direct-acting antiviral and host-targeting agents for treatment of hepatitis B virus infection","volume":"156","author":"Xia","year":"2019","journal-title":"Gastroenterology"},{"issue":"11","key":"key20210426222612_JCTH-D-21-00062-b8","doi-asserted-by":"crossref","first-page":"e02007","DOI":"10.1128\/JVI.02007-17","article-title":"Hepatitis B virus DNA integration occurs early in the viral life cycle in an in vitro infection model via sodium taurocholate cotransporting polypeptide-dependent uptake of enveloped virus particles","volume":"92","author":"Tu","year":"2018","journal-title":"J Virol"},{"issue":"4","key":"key20210426222612_JCTH-D-21-00062-b9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/v9040075","article-title":"HBV DNA integration: Molecular mechanisms and clinical implications","volume":"9","author":"Tu","year":"2017","journal-title":"Viruses"},{"issue":"3","key":"key20210426222612_JCTH-D-21-00062-b10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.02.015","article-title":"LINE(1)s of evidence in HBV-driven liver cancer","volume":"15","author":"Heikenwalder","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"30","key":"key20210426222612_JCTH-D-21-00062-b11","doi-asserted-by":"crossref","first-page":"11135","DOI":"10.1073\/pnas.0403925101","article-title":"Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration","volume":"101","author":"Bill","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b12","doi-asserted-by":"crossref","first-page":"100034","DOI":"10.1016\/j.xinn.2020.100034","article-title":"Insights into hepatitis B virus DNA integration-55 years after virus discovery","volume":"1","author":"Zhao","year":"2020","journal-title":"The Innovation"},{"key":"key20210426222612_JCTH-D-21-00062-b13","doi-asserted-by":"crossref","first-page":"104925","DOI":"10.1016\/j.antiviral.2020.104925","article-title":"Hepatitis B virus biology and life cycle","volume":"182","author":"Tsukuda","year":"2020","journal-title":"Antiviral Res"},{"issue":"7","key":"key20210426222612_JCTH-D-21-00062-b14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3390\/genes9070365","article-title":"Cellular genomic sites of hepatitis B virus DNA integration","volume":"9","author":"Budzinska","year":"2018","journal-title":"Genes (Basel)"},{"issue":"17","key":"key20210426222612_JCTH-D-21-00062-b15","doi-asserted-by":"crossref","first-page":"5350","DOI":"10.1073\/pnas.81.17.5350","article-title":"Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat","volume":"81","author":"Dejean","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key20210426222612_JCTH-D-21-00062-b16","doi-asserted-by":"crossref","first-page":"12992","DOI":"10.1038\/ncomms12992","article-title":"Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma","volume":"7","author":"Zhao","year":"2016","journal-title":"Nat Commun"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jhep.2013.12.014","article-title":"The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinoma","volume":"60","author":"Li","year":"2014","journal-title":"J Hepatol"},{"issue":"7","key":"key20210426222612_JCTH-D-21-00062-b18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ng.2295","article-title":"Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma","volume":"44","author":"Sung","year":"2012","journal-title":"Nat Genet"},{"issue":"4","key":"key20210426222612_JCTH-D-21-00062-b19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1101\/gr.133926.111","article-title":"The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients","volume":"22","author":"Jiang","year":"2012","journal-title":"Genome Res"},{"issue":"7","key":"key20210426222612_JCTH-D-21-00062-b20","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/ng.2291","article-title":"Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators","volume":"44","author":"Fujimoto","year":"2012","journal-title":"Nat Genet"},{"issue":"3","key":"key20210426222612_JCTH-D-21-00062-b21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s12072-020-10016-2","article-title":"Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer","volume":"14","author":"Chen","year":"2020","journal-title":"Hepatol Int"},{"issue":"6","key":"key20210426222612_JCTH-D-21-00062-b22","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/hep.31230","article-title":"Cell-free virus-host chimera DNA from hepatitis B virus integration sites as a circulating biomarker of hepatocellular cancer","volume":"72","author":"Li","year":"2020","journal-title":"Hepatology"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b23","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1534\/g3.118.200900","article-title":"TSD: A computational tool to study the complex structural variants using PacBio targeted sequencing data","volume":"9","author":"Meng","year":"2019","journal-title":"G3 (Bethesda)"},{"issue":"5772","key":"key20210426222612_JCTH-D-21-00062-b24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/286531a0","article-title":"Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAg-producing human hepatocellular carcinoma cell line","volume":"286","author":"Chakraborty","year":"1980","journal-title":"Nature"},{"issue":"11","key":"key20210426222612_JCTH-D-21-00062-b25","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1128\/JVI.62.11.4224-4231.1988","article-title":"Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma","volume":"62","author":"Zhou","year":"1988","journal-title":"J Virol"},{"issue":"12","key":"key20210426222612_JCTH-D-21-00062-b26","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1128\/JVI.65.12.6761-6764.1991","article-title":"Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma","volume":"65","author":"Tokino","year":"1991","journal-title":"J Virol"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1006\/geno.1995.9004","article-title":"A novel PCR technique using Alu-specific primers to identify unknown flanking sequences from the human genome","volume":"29","author":"Minami","year":"1995","journal-title":"Genomics"},{"issue":"12","key":"key20210426222612_JCTH-D-21-00062-b28","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/gb-2011-12-12-236","article-title":"Alu elements: know the SINEs","volume":"12","author":"Deininger","year":"2011","journal-title":"Genome Biol"},{"issue":"43","key":"key20210426222612_JCTH-D-21-00062-b29","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1038\/sj.onc.1204835","article-title":"Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging","volume":"20","author":"Gozuacik","year":"2001","journal-title":"Oncogene"},{"issue":"16","key":"key20210426222612_JCTH-D-21-00062-b30","doi-asserted-by":"crossref","first-page":"8308","DOI":"10.1128\/JVI.00833-10","article-title":"Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection","volume":"84","author":"Mason","year":"2010","journal-title":"J Virol"},{"issue":"4","key":"key20210426222612_JCTH-D-21-00062-b31","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1073\/pnas.0409332102","article-title":"Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection","volume":"102","author":"Mason","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"key20210426222612_JCTH-D-21-00062-b32","doi-asserted-by":"crossref","first-page":"11652","DOI":"10.1073\/pnas.1635109100","article-title":"Hepatocyte turnover during resolution of a transient hepadnaviral infection","volume":"100","author":"Summers","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"key20210426222612_JCTH-D-21-00062-b33","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.1128\/JVI.00700-09","article-title":"Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection","volume":"83","author":"Mason","year":"2009","journal-title":"J Virol"},{"issue":"4","key":"key20210426222612_JCTH-D-21-00062-b34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/carcin\/bgs406","article-title":"Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations","volume":"34","author":"Toh","year":"2013","journal-title":"Carcinogenesis"},{"issue":"12","key":"key20210426222612_JCTH-D-21-00062-b35","doi-asserted-by":"crossref","first-page":"e1003065","DOI":"10.1371\/journal.pgen.1003065","article-title":"Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach","volume":"8","author":"Ding","year":"2012","journal-title":"PLoS Genet"},{"issue":"3","key":"key20210426222612_JCTH-D-21-00062-b36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41588-019-0558-9","article-title":"The landscape of viral associations in human cancers","volume":"52","author":"Zapatka","year":"2020","journal-title":"Nat Genet"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/hep.31231","article-title":"Hepatitis B virus-telomerase reverse transcriptase promoter integration harnesses host ELF4, resulting in telomerase reverse transcriptase gene transcription in hepatocellular carcinoma","volume":"73","author":"Sze","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13059-020-1935-5","article-title":"Opportunities and challenges in long-read sequencing data analysis","volume":"21","author":"Amarasinghe","year":"2020","journal-title":"Genome Biol"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s13046-019-1273-1","article-title":"Viral integration drives multifocal HCC during the occult HBV infection","volume":"38","author":"Chen","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b40","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1128\/JVI.64.2.822-828.1990","article-title":"Structural rearrangement of integrated hepatitis B virus DNA as well as cellular flanking DNA is present in chronically infected hepatic tissues","volume":"64","author":"Takada","year":"1990","journal-title":"J Virol"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b41","first-page":"537","article-title":"Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma","volume":"3","author":"Hatada","year":"1988","journal-title":"Oncogene"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b42","first-page":"49","article-title":"Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas","volume":"51","author":"Slagle","year":"1991","journal-title":"Cancer Res"},{"issue":"8","key":"key20210426222612_JCTH-D-21-00062-b43","first-page":"1653","article-title":"Modification of cyclin A expression by hepatitis B virus DNA integration in a hepatocellular carcinoma","volume":"7","author":"Wang","year":"1992","journal-title":"Oncogene"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0923-2516(06)80086-5","article-title":"Multiple rearrangements and activated expression of c-myc induced by woodchuck hepatitis virus integration in a primary liver tumour","volume":"143","author":"Wei","year":"1992","journal-title":"Res Virol"},{"issue":"11","key":"key20210426222612_JCTH-D-21-00062-b45","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1349-7006.1994.tb02914.x","article-title":"Characteristics of human hepatocellular carcinoma cell lines (Hep-KANO) derived from a non-hepatitic, non-cirrhotic hepatitis B virus carrier","volume":"85","author":"Baba","year":"1994","journal-title":"Jpn J Cancer Res"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0006-291X(92)92391-A","article-title":"Hepatitis B virus DNA integration and expression of an erb B-like gene in human hepatocellular carcinoma","volume":"188","author":"Zhang","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"issue":"6074","key":"key20210426222612_JCTH-D-21-00062-b47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/322070a0","article-title":"Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma","volume":"322","author":"Dejean","year":"1986","journal-title":"Nature"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b48","first-page":"81","article-title":"Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line","volume":"9","author":"Graef","year":"1994","journal-title":"Oncogene"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b49","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ng.3547","article-title":"Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer","volume":"48","author":"Fujimoto","year":"2016","journal-title":"Nat Genet"},{"key":"key20210426222612_JCTH-D-21-00062-b50","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2020-323153","article-title":"Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma","author":"P\u00e9neau","year":"2021","journal-title":"Gut"},{"issue":"15","key":"key20210426222612_JCTH-D-21-00062-b51","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N Engl J Med"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b52","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jhep.2016.05.035","article-title":"Genetic profiling of hepatocellular carcinoma using next-generation sequencing","volume":"65","author":"Schulze","year":"2016","journal-title":"J Hepatol"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b53","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"6257","key":"key20210426222612_JCTH-D-21-00062-b54","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/343457a0","article-title":"The preS2\/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator","volume":"343","author":"Kekul\u00e9","year":"1990","journal-title":"Nature"},{"issue":"3","key":"key20210426222612_JCTH-D-21-00062-b55","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jmv.1890420316","article-title":"Analysis of integrated hepatitis B virus DNA and flanking cellular sequences in a childhood hepatocellular carcinoma","volume":"42","author":"Tsuei","year":"1994","journal-title":"J Med Virol"},{"issue":"8","key":"key20210426222612_JCTH-D-21-00062-b56","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1136\/gut.2004.054452","article-title":"Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas","volume":"54","author":"Murakami","year":"2005","journal-title":"Gut"},{"issue":"9","key":"key20210426222612_JCTH-D-21-00062-b57","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41575-019-0165-3","article-title":"The role of telomeres and telomerase in cirrhosis and liver cancer","volume":"16","author":"Nault","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"15","key":"key20210426222612_JCTH-D-21-00062-b58","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/jnci\/93.15.1171","article-title":"cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome","volume":"93","author":"Horikawa","year":"2001","journal-title":"J Natl Cancer Inst"},{"issue":"15","key":"key20210426222612_JCTH-D-21-00062-b59","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1073\/pnas.87.15.5628","article-title":"Trans-activation function of a 3\u2032 truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues","volume":"87","author":"Takada","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b60","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1006\/viro.1995.1201","article-title":"Enzymatic properties of overexpressed HBV-mevalonate kinase fusion proteins and mevalonate kinase proteins in the human hepatoma cell line PLC\/PRF\/5","volume":"208","author":"Graef","year":"1995","journal-title":"Virology"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b61","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/humu.20701","article-title":"Integration of hepatitis B virus DNA into the myeloid\/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma","volume":"29","author":"Saigo","year":"2008","journal-title":"Hum Mutat"},{"issue":"4","key":"key20210426222612_JCTH-D-21-00062-b62","doi-asserted-by":"crossref","first-page":"e0123175","DOI":"10.1371\/journal.pone.0123175","article-title":"Identification of HBV-MLL4 integration and its molecular basis in Chinese hepatocellular carcinoma","volume":"10","author":"Dong","year":"2015","journal-title":"PLoS One"},{"issue":"38","key":"key20210426222612_JCTH-D-21-00062-b63","doi-asserted-by":"crossref","first-page":"25075","DOI":"10.18632\/oncotarget.25308","article-title":"Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers","volume":"9","author":"Furuta","year":"2018","journal-title":"Oncotarget"},{"issue":"3","key":"key20210426222612_JCTH-D-21-00062-b64","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ccr.2014.01.030","article-title":"Viral-human chimeric transcript predisposes risk to liver cancer development and progression","volume":"25","author":"Lau","year":"2014","journal-title":"Cancer Cell"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b65","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jhep.2015.09.013","article-title":"Hepatitis B virus-human chimeric transcript HBx-LINE1 promotes hepatic injury via sequestering cellular microRNA-122","volume":"64","author":"Liang","year":"2016","journal-title":"J Hepatol"},{"key":"key20210426222612_JCTH-D-21-00062-b66","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ebiom.2018.10.032","article-title":"miR-122 and hepatocellular carcinoma: from molecular biology to therapeutics","volume":"37","author":"Fu","year":"2018","journal-title":"EBioMedicine"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b67","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.aohep.2019.02.002","article-title":"No expression of HBV-human chimeric fusion transcript (HBx-LINE1) among Vietnamese patients with HBV-associated hepatocellular carcinoma","volume":"18","author":"Trung","year":"2019","journal-title":"Ann Hepatol"},{"key":"key20210426222612_JCTH-D-21-00062-b68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13100-019-0191-2","article-title":"LINE-1 ORF2p expression is nearly imperceptible in human cancers","volume":"11","author":"Ardeljan","year":"2019","journal-title":"Mob DNA"},{"key":"key20210426222612_JCTH-D-21-00062-b69","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fchem.2016.00021","article-title":"Links between human LINE-1 retrotransposons and hepatitis virus-related hepatocellular carcinoma","volume":"4","author":"Honda","year":"2016","journal-title":"Front Chem"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b70","doi-asserted-by":"crossref","first-page":"e1000834","DOI":"10.1371\/journal.pgen.1000834","article-title":"Molecular poltergeists: mitochondrial DNA copies (numts) in sequenced nuclear genomes","volume":"6","author":"Hazkani-Covo","year":"2010","journal-title":"PLoS Genet"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b71","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1038\/s41467-020-15336-3","article-title":"Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans","volume":"11","author":"Wei","year":"2020","journal-title":"Nat Commun"},{"issue":"6","key":"key20210426222612_JCTH-D-21-00062-b72","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/hep.27722","article-title":"Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma","volume":"61","author":"Yan","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b73","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41426-018-0145-7","article-title":"Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion","volume":"7","author":"Budzinska","year":"2018","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b74","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MCO.0b013e32834121b1","article-title":"Telomeres, lifestyle, cancer, and aging","volume":"14","author":"Shammas","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b75","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1101\/gr.226993.117","article-title":"L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis","volume":"28","author":"Schauer","year":"2018","journal-title":"Genome Res"},{"issue":"7","key":"key20210426222612_JCTH-D-21-00062-b76","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1053\/j.gastro.2011.02.057","article-title":"Hepatitis B virus limits response of human hepatocytes to interferon-\u03b1 in chimeric mice","volume":"140","author":"L\u00fctgehetmann","year":"2011","journal-title":"Gastroenterology"},{"issue":"16","key":"key20210426222612_JCTH-D-21-00062-b77","doi-asserted-by":"crossref","first-page":"10191","DOI":"10.1074\/jbc.M114.612374","article-title":"Type I interferon controls propagation of long interspersed element-1","volume":"290","author":"Yu","year":"2015","journal-title":"J Biol Chem"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b78","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jmb.2006.01.089","article-title":"The human LINE-1 retrotransposon creates DNA double-strand breaks","volume":"357","author":"Gasior","year":"2006","journal-title":"J Mol Biol"},{"issue":"12","key":"key20210426222612_JCTH-D-21-00062-b79","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41576-019-0165-8","article-title":"Transposable elements in human genetic disease","volume":"20","author":"Payer","year":"2019","journal-title":"Nat Rev Genet"},{"issue":"10","key":"key20210426222612_JCTH-D-21-00062-b80","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease","volume":"20","author":"Greenberg","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"Suppl 1","key":"key20210426222612_JCTH-D-21-00062-b81","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/ncponc0354","article-title":"DNA methylation and gene silencing in cancer","volume":"2","author":"Baylin","year":"2005","journal-title":"Nat Clin Pract Oncol"},{"issue":"6","key":"key20210426222612_JCTH-D-21-00062-b82","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/hep.29479","article-title":"Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B","volume":"66","author":"Hong","year":"2017","journal-title":"Hepatology"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b83","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00281-020-00780-6","article-title":"Epigenetic modulation in chronic hepatitis B virus infection","volume":"42","author":"Dandri","year":"2020","journal-title":"Semin Immunopathol"},{"issue":"3","key":"key20210426222612_JCTH-D-21-00062-b84","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1101\/gr.175240.114","article-title":"DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences","volume":"25","author":"Watanabe","year":"2015","journal-title":"Genome Res"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b85","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12916-020-01667-x","article-title":"Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing","volume":"18","author":"Zhang","year":"2020","journal-title":"BMC Med"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b86","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1073\/pnas.0307422100","article-title":"Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy","volume":"101","author":"Summers","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"key20210426222612_JCTH-D-21-00062-b87","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat Protoc"},{"key":"key20210426222612_JCTH-D-21-00062-b88","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fcimb.2017.00091","article-title":"Removal of integrated hepatitis B virus DNA using CRISPR-Cas9","volume":"7","author":"Li","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"key20210426222612_JCTH-D-21-00062-b89","first-page":"25","article-title":"The advancement of immunotherapy in hepatocellular carcinoma","volume":"6","author":"Ni","year":"2020","journal-title":"Hepatoma Res"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b90","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0039-3399534","article-title":"Impact of viral etiologies on the development of novel immunotherapy for hepatocellular carcinoma","volume":"40","author":"Lim","year":"2020","journal-title":"Semin Liver Dis"},{"issue":"6","key":"key20210426222612_JCTH-D-21-00062-b91","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1053\/j.gastro.2019.01.251","article-title":"Use of expression profiles of HBV-DNA integrated into genomes of hepatocellular carcinoma cells to select T cells for immunotherapy","volume":"156","author":"Tan","year":"2019","journal-title":"Gastroenterology"},{"issue":"7","key":"key20210426222612_JCTH-D-21-00062-b92","doi-asserted-by":"crossref","first-page":"e01663","DOI":"10.1128\/JVI.01663-19","article-title":"Discovery and selection of hepatitis B virus-derived T cell epitopes for global immunotherapy based on viral indispensability, conservation, and HLA-binding strength","volume":"94","author":"de Beijer","year":"2020","journal-title":"J Virol"},{"issue":"10","key":"key20210426222612_JCTH-D-21-00062-b93","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1128\/JVI.69.10.6158-6169.1995","article-title":"High-level hepatitis B virus replication in transgenic mice","volume":"69","author":"Guidotti","year":"1995","journal-title":"J Virol"},{"issue":"8","key":"key20210426222612_JCTH-D-21-00062-b94","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1101\/gad.1.8.773","article-title":"The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma","volume":"1","author":"Nagaya","year":"1987","journal-title":"Genes Dev"},{"issue":"38","key":"key20210426222612_JCTH-D-21-00062-b95","doi-asserted-by":"crossref","first-page":"10732","DOI":"10.3748\/wjg.v21.i38.10732","article-title":"Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis","volume":"21","author":"Geng","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"21","key":"key20210426222612_JCTH-D-21-00062-b96","first-page":"7803","article-title":"Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues","volume":"61","author":"Tu","year":"2001","journal-title":"Cancer Res"},{"issue":"16","key":"key20210426222612_JCTH-D-21-00062-b97","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1158\/1078-0432.CCR-07-5082","article-title":"COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis","volume":"14","author":"Ma","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b98","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/hep.25979","article-title":"C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by C-Jun\/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma","volume":"57","author":"Sze","year":"2013","journal-title":"Hepatology"},{"issue":"34","key":"key20210426222612_JCTH-D-21-00062-b99","doi-asserted-by":"crossref","first-page":"55110","DOI":"10.18632\/oncotarget.10399","article-title":"Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"key20210426222612_JCTH-D-21-00062-b100","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jhep.2014.04.041","article-title":"Hepatitis B virus PreS\/S gene variants: pathobiology and clinical implications","volume":"61","author":"Pollicino","year":"2014","journal-title":"J Hepatol"},{"issue":"409","key":"key20210426222612_JCTH-D-21-00062-b101","doi-asserted-by":"crossref","first-page":"eaan0241","DOI":"10.1126\/scitranslmed.aan0241","article-title":"RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg","volume":"9","author":"Wooddell","year":"2017","journal-title":"Sci Transl Med"},{"issue":"6","key":"key20210426222612_JCTH-D-21-00062-b102","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1073\/pnas.78.6.3906","article-title":"State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases","volume":"78","author":"Br\u00e9chot","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"41","key":"key20210426222612_JCTH-D-21-00062-b103","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.3748\/wjg.v11.i41.6416","article-title":"Integration of hepatitis B virus DNA into chromosomal DNA during acute hepatitis B","volume":"11","author":"Kimbi","year":"2005","journal-title":"World J Gastroenterol"},{"issue":"9","key":"key20210426222612_JCTH-D-21-00062-b104","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/jvh.12380","article-title":"Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection","volume":"22","author":"Tu","year":"2015","journal-title":"J Viral Hepat"},{"issue":"11","key":"key20210426222612_JCTH-D-21-00062-b105","doi-asserted-by":"crossref","first-page":"a016550","DOI":"10.1101\/cshperspect.a016550","article-title":"Recombination and replication","volume":"6","author":"Syeda","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"22","key":"key20210426222612_JCTH-D-21-00062-b106","doi-asserted-by":"crossref","first-page":"12871","DOI":"10.1073\/pnas.2135498100","article-title":"Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer","volume":"100","author":"Vilenchik","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b107","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-virology-092917-043534","article-title":"Virus DNA replication and the host DNA damage response","volume":"5","author":"Weitzman","year":"2018","journal-title":"Annu Rev Virol"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b108","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1053\/j.gastro.2016.07.012","article-title":"HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant","volume":"151","author":"Mason","year":"2016","journal-title":"Gastroenterology"},{"key":"key20210426222612_JCTH-D-21-00062-b109","doi-asserted-by":"crossref","first-page":"e00049","DOI":"10.7554\/eLife.00049","article-title":"Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus","volume":"1","author":"Yan","year":"2012","journal-title":"Elife"},{"issue":"5","key":"key20210426222612_JCTH-D-21-00062-b110","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/gast.1996.v110.pm8613059","article-title":"Effect of hepatocyte proliferation and cellular DNA synthesis on hepatitis B virus replication","volume":"110","author":"Ozer","year":"1996","journal-title":"Gastroenterology"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b111","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hep.29463","article-title":"Hepatitis B virus pregenomic RNA in hepatocellular carcinoma: A nosological and prognostic determinant","volume":"67","author":"Halgand","year":"2018","journal-title":"Hepatology"},{"issue":"1","key":"key20210426222612_JCTH-D-21-00062-b112","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41467-018-03276-y","article-title":"Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"issue":"13","key":"key20210426222612_JCTH-D-21-00062-b113","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1073\/pnas.1819799116","article-title":"Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy","volume":"116","author":"Qu","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15_suppl","key":"key20210426222612_JCTH-D-21-00062-b114","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1200\/JCO.2019.37.15_suppl.4090","article-title":"Cell-free junctional DNA fragment from hepatitis B virus integration in HCC for monitoring postresection recurrence and clonality","volume":"37","author":"Wang","year":"2019","journal-title":"J Clin Oncol"}],"container-title":["Journal of Clinical and Translational Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.xiahepublishing.com\/2310-8819\/JCTH-2021-00062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:19:50Z","timestamp":1783707590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.xiahepublishing.com\/2310-8819\/JCTH-2021-00062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,25]]},"references-count":114,"journal-issue":{"issue":"000","published-online":{"date-parts":[[2021,4,25]]},"published-print":{"date-parts":[[2021,4,25]]}},"alternative-id":["10.14218\/JCTH.2021.00062"],"URL":"https:\/\/doi.org\/10.14218\/jcth.2021.00062","relation":{},"ISSN":["2225-0719","2310-8819"],"issn-type":[{"value":"2225-0719","type":"print"},{"value":"2310-8819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,25]]}}}