{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:05Z","timestamp":1788397385966,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","award":["SBAG-COSTB15-2356"],"award-info":[{"award-number":["SBAG-COSTB15-2356"]}],"id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","award":["00.02.201.002"],"award-info":[{"award-number":["00.02.201.002"]}],"id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["SBAG-COSTB15-2356"],"award-info":[{"award-number":["SBAG-COSTB15-2356"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["00.02.201.002"],"award-info":[{"award-number":["00.02.201.002"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.14219\/jada.archive.2004.0127","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T23:13:27Z","timestamp":1389222807000},"page":"1728-1732","source":"Crossref","is-referenced-by-count":17,"title":["Serum and gingival crevicular fluid levels of ciprofloxacin in patients with periodontitis"],"prefix":"10.1016","volume":"135","author":[{"given":"TOLGA F.","family":"T\u00d6Z\u00dcM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AY\u015eEG\u00dcL","family":"YILDIRIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FERIHA","family":"\u00c7A\u011eLAYAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AYSUN","family":"DIN\u00c7EL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ATILLA","family":"BOZKURT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.14219\/jada.archive.2004.0127_bib1","series-title":"Glossary of periodontal terms","first-page":"40","author":"The American Academy of Periodontology","year":"2001"},{"issue":"1","key":"10.14219\/jada.archive.2004.0127_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib3","series-title":"Carranza&apos;s clinical periodontology","first-page":"132","article-title":"Microbial interactions with the host in periodontal diseases","author":"Haake","year":"2002"},{"issue":"2","key":"10.14219\/jada.archive.2004.0127_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-051X.1987.tb00949.x","article-title":"The capability of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius to indicate progressive periodontitis: a retrospective study","volume":"14","author":"Bragd","year":"1987","journal-title":"J Clin Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib5","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1902\/jop.2000.71.9.1448","article-title":"Gingival fluid ciprofloxacin levels at healthy and inflamed human periodontal sites","volume":"71","author":"Conway","year":"2000","journal-title":"J Periodontol"},{"issue":"June","key":"10.14219\/jada.archive.2004.0127_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0757.1994.tb00022.x","article-title":"Antimicrobial strategies for treatment of periodontal diseases","volume":"5","author":"Goodson","year":"1994","journal-title":"Periodontol 2000"},{"key":"10.14219\/jada.archive.2004.0127_bib7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1034\/j.1600-0757.2002.280106.x","article-title":"Systemic antibiotics in the treatment of periodontal disease","volume":"28","author":"Slots","year":"2002","journal-title":"Periodontol 2000"},{"key":"10.14219\/jada.archive.2004.0127_bib8","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1902\/jop.1996.67.11.1143","article-title":"Microbiological response to mechanical treatment in combination with adjunctive therapy: a review of the literature","volume":"67","author":"Bollen","year":"1996","journal-title":"J Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib9","first-page":"221","article-title":"The relationship between periodontal status and peripheral levels of neutrophils in two consanguineous siblings with severe congenital neutropenia: case reports","volume":"34","author":"T\u00f6z\u00fcm","year":"2003","journal-title":"Quintessence Int"},{"key":"10.14219\/jada.archive.2004.0127_bib10","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1034\/j.1600-051X.2002.290810.x","article-title":"In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics","volume":"29","author":"M\u00fcller","year":"2002","journal-title":"J Clin Periodontol"},{"issue":"2","key":"10.14219\/jada.archive.2004.0127_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/AAC.17.2.193","article-title":"Sensitive assay for measuring tetracycline levels in gingival crevice fluid","volume":"17","author":"Gordon","year":"1980","journal-title":"Antimicrob Agents Chemother"},{"key":"10.14219\/jada.archive.2004.0127_bib12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1600-051X.1986.tb02240.x","article-title":"Concentration of doxycycline in human gingival fluid","volume":"13","author":"Pascale","year":"1986","journal-title":"J Clin Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib13","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/AAC.46.6.1980-1984.2002","article-title":"Effect of ciprofloxacin on killing of Actinobacillus actinomycetemcomitans by polymorphonuclear leukocytes","volume":"46","author":"Cacchillo","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.14219\/jada.archive.2004.0127_bib14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jlb.56.6.672","article-title":"Neutrophils, host defense, and inflammation: a double-edged sword","volume":"56","author":"Smith","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.14219\/jada.archive.2004.0127_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1902\/jop.1987.58.8.529","article-title":"Tissue localization of Actinobacillus actinomycetemcomitans in human periodontitis, I: light, immunofluorescence and electron microscopic studies","volume":"58","author":"Christersson","year":"1987","journal-title":"J Periodontol"},{"issue":"June","key":"10.14219\/jada.archive.2004.0127_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal diseases","volume":"5","author":"Haffajee","year":"1994","journal-title":"Periodontol 2000"},{"issue":"1","key":"10.14219\/jada.archive.2004.0127_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/jac\/16.1.67","article-title":"Uptake of ciprofloxacin by human neutrophils","volume":"16","author":"Easmon","year":"1985","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"10.14219\/jada.archive.2004.0127_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1099\/00222615-32-1-15","article-title":"Interactions of the oxygen-dependent antimicrobial system of the human neutrophil with difloxacin, ciprofloxacin, pefloxacin and fleroxacin in the intraphagocytic eradication of Staphylococcus aureus","volume":"32","author":"van Rensburg","year":"1990","journal-title":"J Med Microbiol"},{"key":"10.14219\/jada.archive.2004.0127_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy, I: prevalence and severity","volume":"21","author":"L\u00f6e","year":"1963","journal-title":"Acta Odontol Scand"},{"issue":"February","key":"10.14219\/jada.archive.2004.0127_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy, II: correlation between oral hygiene and periodontal conditions","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol Scand"},{"key":"10.14219\/jada.archive.2004.0127_bib21","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1902\/jop.1998.69.10.1155","article-title":"Analysis of gingival crevicular fluid intracytoplasmic enzyme activity in patients with adult periodontitis and rapidly progressive periodontitis: a longitudinal study model with periodontal treatment","volume":"69","author":"Atici","year":"1998","journal-title":"J Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1600-0765.1973.tb00773.x","article-title":"Comparison between orifice and intracrevicular methods of sampling gingival fluid","volume":"8","author":"Egelberg","year":"1973","journal-title":"J Periodontal Res"},{"key":"10.14219\/jada.archive.2004.0127_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1034\/j.1600-051x.2000.027007481.x","article-title":"Methodological considerations in the assessment of gingival crevicular fluid volume","volume":"27","author":"Deinzer","year":"2000","journal-title":"J Clin Periodontol"},{"issue":"2","key":"10.14219\/jada.archive.2004.0127_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2710.1992.tb01277.x","article-title":"A simple high-performance liquid chromatographic assay for ciprofloxacin in human serum","volume":"17","author":"Jim","year":"1992","journal-title":"J Clin Pharm Ther"},{"key":"10.14219\/jada.archive.2004.0127_bib25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1600-051X.1987.tb01536.x","article-title":"The effect of plaque control after scaling and root planing on the subgingival microflora in human periodontitis","volume":"14","author":"Lavanchy","year":"1987","journal-title":"J Clin Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1902\/jop.1988.59.4.222","article-title":"Bacterial invasion in root cementum and radicular dentin of periodontally diseased teeth in humans: a reservoir of periodontopathic bacteria","volume":"59","author":"Adriaens","year":"1988","journal-title":"J Periodontol"},{"issue":"February","key":"10.14219\/jada.archive.2004.0127_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0757.1996.tb00068.x","article-title":"Systemic antibiotic therapy in periodontics","volume":"10","author":"van Winkelhoff","year":"1996","journal-title":"Periodontol 2000"},{"issue":"2","key":"10.14219\/jada.archive.2004.0127_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-051X.1981.tb02351.x","article-title":"Concentration of tetracycline in human gingival fluid after single doses","volume":"8","author":"Gordon","year":"1981","journal-title":"J Clin Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1902\/jop.1981.52.10.609","article-title":"Tetracycline: levels achievable in gingival crevice fluid and in vitro effect on subgingival organisms, part I: concentrations in crevicular fluid after repeated doses","volume":"52","author":"Gordon","year":"1981","journal-title":"J Periodontol"},{"issue":"2","key":"10.14219\/jada.archive.2004.0127_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1902\/jop.1986.57.2.104","article-title":"Serum and crevicular fluid concentrations after a single oral dose of metronidazole","volume":"57","author":"Britt","year":"1986","journal-title":"J Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib31","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1177\/00220345910700050901","article-title":"Single-dose concentrations of tinidazole in gingival crevicular fluid, serum, and gingival tissue in adults with periodontitis","volume":"70","author":"Liew","year":"1991","journal-title":"J Dent Res"},{"key":"10.14219\/jada.archive.2004.0127_bib32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1600-051X.1995.tb00166.x","article-title":"Tetracycline-resistant micro-organisms recovered from patients with refractory periodontal disease","volume":"22","author":"Olsvik","year":"1995","journal-title":"J Clin Periodontol"},{"key":"10.14219\/jada.archive.2004.0127_bib33","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1128\/CMR.2.4.378","article-title":"Fluoroquinolone antimicrobial agents","volume":"2","author":"Wolfson","year":"1989","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.14219\/jada.archive.2004.0127_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1399-302X.1993.tb00655.x","article-title":"Killing of Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus by human polymorphonuclear leukocytes in serum and saliva","volume":"8","author":"Holm","year":"1993","journal-title":"Oral Microbiol Immunol"},{"key":"10.14219\/jada.archive.2004.0127_bib35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1399-302X.1990.tb00428.x","article-title":"In vitro antimicrobial sensitivity of enteric rods and pseudomonads from advanced adult periodontitis","volume":"5","author":"Slots","year":"1990","journal-title":"Oral Microbiol Immunol"},{"key":"10.14219\/jada.archive.2004.0127_bib36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1399-302X.1992.tb00034.x","article-title":"Enterococci in human periodontitis","volume":"7","author":"Rams","year":"1992","journal-title":"Oral Microbiol Immunol"},{"key":"10.14219\/jada.archive.2004.0127_bib37","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1128\/AAC.36.12.2634","article-title":"In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations","volume":"36","author":"Pavicic","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"10.14219\/jada.archive.2004.0127_bib38","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1128\/AAC.34.5.934","article-title":"Penetration of ciprofloxacin into human pleural fluid","volume":"34","author":"Jacobs","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"10.14219\/jada.archive.2004.0127_bib39","first-page":"2388","article-title":"The intravitreal penetration of orally administered ciprofloxacin in humans","volume":"32","author":"Keren","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.14219\/jada.archive.2004.0127_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/AAC.29.3.405","article-title":"Ciprofloxacin concentrations in bone and muscle after oral dosing","volume":"29","author":"Fong","year":"1986","journal-title":"Antimicrob Agents Chemother"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714632931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714632931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:20:02Z","timestamp":1629332402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817714632931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0002817714632931"],"URL":"https:\/\/doi.org\/10.14219\/jada.archive.2004.0127","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}