{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:32:23Z","timestamp":1787509943527,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.14219\/jada.archive.2008.0051","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T19:45:28Z","timestamp":1389210328000},"page":"1389-1397","source":"Crossref","is-referenced-by-count":23,"title":["The Relationship of Periodontal Disease to Diseases and Disorders at Distant Sites"],"prefix":"10.1016","volume":"139","author":[{"given":"Ira B.","family":"Lamster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick P.","family":"DePaola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui V.","family":"Oppermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos N.","family":"Papapanou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Wilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.14219\/jada.archive.2008.0051_bib1","series-title":"Oral Health in America: A Report of the Surgeon General\u2014Executive Summary","first-page":"11","author":"U.S. Department of Health and Human Services","year":"2000"},{"issue":"suppl 1","key":"10.14219\/jada.archive.2008.0051_bib2","first-page":"1","article-title":"Proceedings and consensus opinion from the Global Oral and Systemic Health Summit: present evidence and future directions","author":"DePaola","year":"2007","journal-title":"Grand Rounds Oral-Systemic Med"},{"key":"10.14219\/jada.archive.2008.0051_bib3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/archinte.1912.00060160087007","article-title":"Chronic focal infections and their etiologic relations to arthritis and nephritis","volume":"9","author":"Billings","year":"1912","journal-title":"Arch Intern Med"},{"issue":"6676","key":"10.14219\/jada.archive.2008.0051_bib4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/bmj.298.6676.779","article-title":"Association between dental health and acute myocardial infarction","volume":"298","author":"Mattila","year":"1989","journal-title":"BMJ"},{"issue":"12","key":"10.14219\/jada.archive.2008.0051_bib5","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1902\/jop.2007.070140","article-title":"Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis","volume":"78","author":"Mustapha","year":"2007","journal-title":"J Periodontol"},{"issue":"5","key":"10.14219\/jada.archive.2008.0051_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ahj.2007.06.037","article-title":"The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis","volume":"154","author":"Bahekar","year":"2007","journal-title":"Am Heart J"},{"issue":"9","key":"10.14219\/jada.archive.2008.0051_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ajic.2005.02.005","article-title":"A review of the possible role of oral and dental colonization on the occurrence of health care: associated pneumonia\u2014underappreciated risk and a call for interventions","volume":"33","author":"Garcia","year":"2005","journal-title":"Am J Infect Control"},{"issue":"6","key":"10.14219\/jada.archive.2008.0051_bib8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1601-0825.2007.01410a.x","article-title":"Oral biofilms, periodontitis, and pulmonary infections","volume":"13","author":"Paju","year":"2007","journal-title":"Oral Dis"},{"issue":"12","key":"10.14219\/jada.archive.2008.0051_bib9","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1902\/jop.2007.070196","article-title":"Intrauterine growth restriction, low birth weight, and preterm birth: adverse pregnancy outcomes and their association with maternal periodontitis","volume":"78","author":"Siqueira","year":"2007","journal-title":"J Periodontol"},{"issue":"2","key":"10.14219\/jada.archive.2008.0051_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/JPM.2007.039","article-title":"The relationship between periodontal disease, bacterial vaginosis, and preterm birth","volume":"35","author":"Pretorius","year":"2007","journal-title":"J Perinat Med"},{"issue":"1","key":"10.14219\/jada.archive.2008.0051_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1902\/annals.2001.6.1.99","article-title":"Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective","volume":"6","author":"Taylor","year":"2001","journal-title":"Ann Periodontol"},{"issue":"8","key":"10.14219\/jada.archive.2008.0051_bib12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1902\/jop.2006.050459","article-title":"Diabetes mellitus and periodontal diseases","volume":"77","author":"Mealey","year":"2006","journal-title":"J Periodontol"},{"issue":"2","key":"10.14219\/jada.archive.2008.0051_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2337\/dc06-1184","article-title":"Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes","volume":"30","author":"Shultis","year":"2007","journal-title":"Diabetes Care"},{"issue":"2","key":"10.14219\/jada.archive.2008.0051_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jnci\/djk021","article-title":"A prospective study of periodontal disease and pancreatic cancer in US male health professionals","volume":"99","author":"Michaud","year":"2007","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"10.14219\/jada.archive.2008.0051_bib15","first-page":"70","article-title":"Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population","volume":"35","author":"de Pablo","year":"2008","journal-title":"J Rheumatol"},{"issue":"3","key":"10.14219\/jada.archive.2008.0051_bib16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/RHU.0b013e3180690616","article-title":"Control of periodontal infection reduces the severity of active rheumatoid arthritis","volume":"13","author":"Al-Katma","year":"2007","journal-title":"J Clin Rheumatol"},{"issue":"11 suppl","key":"10.14219\/jada.archive.2008.0051_bib17","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1902\/jop.2005.76.11-S.2089","article-title":"Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease","volume":"76","author":"Beck","year":"2005","journal-title":"J Periodontol"},{"issue":"suppl K","key":"10.14219\/jada.archive.2008.0051_bib18","first-page":"54","article-title":"Missing teeth and ischaemic heart disease in men aged 45\u201364 years","volume":"14","author":"Paunio","year":"1993","journal-title":"Eur Heart J"},{"issue":"8","key":"10.14219\/jada.archive.2008.0051_bib19","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1161\/01.ATV.0000082462.26258.FE","article-title":"Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice","volume":"23","author":"Lalla","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"10.14219\/jada.archive.2008.0051_bib20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/hc0702.104178","article-title":"Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model (published correction appears in Circulation 2002;105[13]:1617)","volume":"105","author":"Li","year":"2002","journal-title":"Circulation"},{"issue":"10","key":"10.14219\/jada.archive.2008.0051_bib21","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1902\/jop.2000.71.10.1554","article-title":"Identification of periodontal pathogens in atheromatous plaques","volume":"71","author":"Haraszthy","year":"2000","journal-title":"J Periodontol"},{"issue":"3","key":"10.14219\/jada.archive.2008.0051_bib22","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.micinf.2005.09.004","article-title":"Detection of bacterial DNA in atheromatous plaques by quantitative PCR","volume":"8","author":"Kozarov","year":"2006","journal-title":"Microbes Infect"},{"issue":"6","key":"10.14219\/jada.archive.2008.0051_bib23","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.ahj.2004.09.059","article-title":"Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis","volume":"149","author":"Seinost","year":"2005","journal-title":"Am Heart J"},{"issue":"9","key":"10.14219\/jada.archive.2008.0051_bib24","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1600-051X.2007.01113.x","article-title":"Periodontal therapy alters gene expression of peripheral blood monocytes","volume":"34","author":"Papapanou","year":"2007","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.14219\/jada.archive.2008.0051_bib25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2337\/diacare.16.1.329","article-title":"Periodontal disease: the sixth complication of diabetes mellitus","volume":"16","author":"L\u00f6e","year":"1993","journal-title":"Diabetes Care"},{"issue":"13","key":"10.14219\/jada.archive.2008.0051_bib26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1601-0825.2008.01442.x","article-title":"Periodontal disease: associations with diabetes, glycemic control and complications","volume":"14","author":"Taylor","year":"2008","journal-title":"Oral Dis"},{"issue":"11 suppl","key":"10.14219\/jada.archive.2008.0051_bib27","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1902\/jop.2005.76.11-S.2144","article-title":"Periodontal therapy reduces the rate of preterm low birth weight in women with pregnancy-associated gingivitis","volume":"76","author":"Lopez","year":"2005","journal-title":"J Periodontol"},{"issue":"5","key":"10.14219\/jada.archive.2008.0051_bib28","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.ajog.2005.11.059","article-title":"Maternal periodontal disease in early pregnancy and risk for a small-for-gestational-age infant","volume":"194","author":"Boggess","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.14219\/jada.archive.2008.0051_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1902\/annals.2003.8.1.70","article-title":"Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review","volume":"8","author":"Scannapieco","year":"2003","journal-title":"Ann Periodontol"},{"issue":"2","key":"10.14219\/jada.archive.2008.0051_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1471-0528.2005.00827.x","article-title":"Periodontal disease and adverse pregnancy outcomes: a systemic review","volume":"113","author":"Xiong","year":"2006","journal-title":"Br J Obstet Gynaecol"},{"issue":"9","key":"10.14219\/jada.archive.2008.0051_bib31","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.ogx.0000279292.63435.40","article-title":"Periodontal disease and pregnancy outcomes: state-of-the-science","volume":"62","author":"Xiong","year":"2007","journal-title":"Obstet Gynecol Surv"},{"issue":"1","key":"10.14219\/jada.archive.2008.0051_bib32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1902\/jop.2001.72.1.50","article-title":"Potential associations between chronic respiratory disease and periodontal disease: analysis of National Health and Nutrition Examination Survey III","volume":"72","author":"Scannapieco","year":"2001","journal-title":"J Periodontol"},{"issue":"3","key":"10.14219\/jada.archive.2008.0051_bib33","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1046\/j.1532-5415.2002.50106.x","article-title":"Oral care reduces pneumonia in older patients in nursing homes","volume":"50","author":"Yoneyama","year":"2002","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"10.14219\/jada.archive.2008.0051_bib34","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of periodontitis and endothelial function","volume":"356","author":"Tonetti","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"10.14219\/jada.archive.2008.0051_bib35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1902\/jop.2008.070223","article-title":"The Periodontitis and Vascular Events (PAVE) pilot study: adverse events","volume":"79","author":"Beck","year":"2008","journal-title":"J Periodontol"},{"issue":"8","key":"10.14219\/jada.archive.2008.0051_bib36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1902\/jop.1997.68.8.713","article-title":"Treatment of periodontal disease in diabetics reduces glycated hemoglobin","volume":"68","author":"Grossi","year":"1997","journal-title":"J Periodontol"},{"issue":"5","key":"10.14219\/jada.archive.2008.0051_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1601-0825.2005.01119.x","article-title":"The effect of periodontal therapy on uncontrolled type 2 diabetes mellitus in older subjects","volume":"11","author":"Promsudthi","year":"2005","journal-title":"Oral Dis"},{"issue":"8","key":"10.14219\/jada.archive.2008.0051_bib38","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1902\/jop.2003.74.8.1214","article-title":"Periodontal disease and preterm birth: results of a pilot intervention study","volume":"74","author":"Jeffcoat","year":"2003","journal-title":"J Periodontol"},{"issue":"18","key":"10.14219\/jada.archive.2008.0051_bib39","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1056\/NEJMoa062249","article-title":"Treatment of periodontal disease and the risk of preterm birth","volume":"355","author":"Michalowicz","year":"2006","journal-title":"N Engl J Med"},{"issue":"5","key":"10.14219\/jada.archive.2008.0051_bib40","first-page":"621","article-title":"Recent trends in dental visits and private dental insurance, 1989 and 1999","volume":"134","author":"Wall","year":"2003","journal-title":"JADA"},{"issue":"5","key":"10.14219\/jada.archive.2008.0051_bib41","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/00001888-200505000-00004","article-title":"An oral health curriculum for medical students at the University of Washington","volume":"80","author":"Mouradian","year":"2005","journal-title":"Acad Med"},{"key":"10.14219\/jada.archive.2008.0051_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1472-6963-6-103","article-title":"An examination of periodontal treatment and per member per month (PMPM) medical costs in an insured population","volume":"6","author":"Albert","year":"2006","journal-title":"MBC Health Serv Res"},{"key":"10.14219\/jada.archive.2008.0051_bib43","author":"American Dental Association"},{"key":"10.14219\/jada.archive.2008.0051_bib44","author":"American Academy of Periodontology"},{"key":"10.14219\/jada.archive.2008.0051_bib45","author":"National Institute of Dental and Craniofacial Research"},{"key":"10.14219\/jada.archive.2008.0051_bib46","author":"Moloney"},{"issue":"8 suppl 2","key":"10.14219\/jada.archive.2008.0051_bib47","first-page":"II2","article-title":"Changing provider behavior: an overview of systematic reviews of interventions","volume":"39","author":"Grimshaw","year":"2001","journal-title":"Med Care"},{"key":"10.14219\/jada.archive.2008.0051_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003030","article-title":"Continuing education meetings and workshops: effects on professional practice and healthcare outcomes","volume":"1","author":"O'Brien","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"10.14219\/jada.archive.2008.0051_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000259.pub2","article-title":"Audit and feedback: effects on professional practice and healthcare outcomes","volume":"2","author":"Jamtvedt","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.14219\/jada.archive.2008.0051_bib50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1748-5908-2-20","article-title":"Information transfer: what do decision makers want and need from researchers?","volume":"2","author":"Dobbins","year":"2007","journal-title":"Implement Sci"},{"key":"10.14219\/jada.archive.2008.0051_bib51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1748-5908-2-29","article-title":"Turning evidence into recommendations: protocol for a study of guideline development groups","volume":"2","author":"Michie","year":"2007","journal-title":"Implement Sci"},{"issue":"8 suppl 2","key":"10.14219\/jada.archive.2008.0051_bib52","first-page":"II85","article-title":"Optimal methods for guideline implementation: Conclusions from Leeds Castle meeting","volume":"39","author":"Gross","year":"2001","journal-title":"Med Care"},{"issue":"suppl","key":"10.14219\/jada.archive.2008.0051_bib53","first-page":"1","article-title":"Report of the independent panel of experts of the Scottsdale Project","author":"Hein","year":"2007","journal-title":"Grand Rounds Oral-Systemic Med"},{"issue":"4","key":"10.14219\/jada.archive.2008.0051_bib54","first-page":"e81","article-title":"Obstetricians' knowledge and practice behaviors concerning periodontal health and preterm delivery and low birth weight","volume":"81","author":"Wilder","year":"2007","journal-title":"J Dent Hyg"},{"issue":"spec iss A","key":"10.14219\/jada.archive.2008.0051_bib55","article-title":"Prenatal care providers' oral health and pregnancy knowledge behaviors","volume":"87","author":"Thomas","year":"2008","journal-title":"J Dent Res"},{"issue":"2","key":"10.14219\/jada.archive.2008.0051_bib56","first-page":"117","article-title":"Challenges associated with the evaluation of a dental health promotion program in a deprived urban area","volume":"24","author":"Davies","year":"2007","journal-title":"Community Dent Health"},{"issue":"9","key":"10.14219\/jada.archive.2008.0051_bib57","first-page":"711","article-title":"Strategies and approaches in oral disease presentation and health promotion","volume":"83","author":"Watt","year":"2005","journal-title":"Bull WHO"},{"issue":"6","key":"10.14219\/jada.archive.2008.0051_bib58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1600-0765.2007.00983.x","article-title":"Diabetes in the dental office: using NHANES III to estimate the probability of undiagnosed disease","volume":"42","author":"Borrell","year":"2007","journal-title":"J Periodontol Res"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714654179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714654179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T09:20:02Z","timestamp":1538904002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817714654179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0002817714654179"],"URL":"https:\/\/doi.org\/10.14219\/jada.archive.2008.0051","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}